A5022852271- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Nitric Oxide and Endothelin Effects
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Infectious Aortic and Vascular Conditions
- Coronary Artery Anomalies
- Cardiac pacing and defibrillation studies
- Sarcoma Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Appendicitis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Shoulder and Clavicle Injuries
- Chronic Kidney Disease and Diabetes
Baylor University Medical Center
2024
Baylor Medical Center at Garland
2024
Cairns Hospital
2024
Maharani Laxmi Bai Medical College
2023
King's College Hospital
2011-2022
King's College Hospital NHS Foundation Trust
2011-2022
Hammersmith Hospital
2018-2022
Imperial College Healthcare NHS Trust
2022
AstraZeneca (Sweden)
2021
King's College London
2009-2018
Anecdotal observations suggest that sub-clinical electrophysiological manifestations of arrhythmogenic right ventricular cardiomyopathy (ARVC) develop before detectable structural changes ensue on cardiac imaging. To test this hypothesis, we investigated a murine model with conditional genetic deletion one desmoplakin allele (DSP ±) and compared the findings to patients non-diagnostic features ARVC who carried mutations in desmoplakin. Murine: DSP (±) mice underwent electrophysiological,...
Two principal mechanisms are thought to be responsible for Brugada syndrome (BS): (1) right ventricular (RV) conduction delay and (2) RV subepicardial action potential shortening. This in vivo high-density mapping study evaluated the repolarization properties of BS subjects.A noncontact array was positioned 18 patients 20 controls. Using a standard S(1)-S(2) protocol, restitution curves local activation time recovery interval were constructed determine maximal slopes. Significant regional...
The aim of this pilot study was to assess the feasibility a perioperative care bundle for enhanced recovery after cardiac surgery (ERACS).A prospective, observational study.A major urban teaching and university hospital tertiary referral center.The included 53 patients undergoing before implementation an ERACS protocol (pre-ERACS group) 52 (ERACS group).Based on recommendations from consensus review in colorectal surgery, following applied: detailed preoperative information, avoidance...
<h3>Objective</h3> Cyclosporin-A (CsA) has been reported to reduce myocardial infarct size in both the experimental and clinical settings. This protective effect is dependent on its ability prevent opening of mitochondrial permeability transition pore, a critical determinant cell death setting acute ischaemia-reperfusion injury. Whether CsA can extent peri-operative injury (PMI) patients undergoing coronary artery bypass graft (CABG) surgery unknown, investigated this randomised controlled...
Background Because of demographic changes, a growing number elderly patients present with mitral valve ( MV ) disease. Although repair ‐repair) is the “gold standard” treatment for disease, in patients, there controversy about whether ‐repair superior to replacement. We reviewed results after surgery treated over past 20 years. Methods and Results Our in‐hospital database was explored who underwent between 1994 2015. Survival data, obtained from National Health Service central register, were...
Acute aortic dissection type-A (AADA) is a life threatening condition which requires emergency surgery. Surgery usually performed by cardiac surgeons with various levels of surgical experience. We compared the short-term perioperative outcome and long-term survival patients operated specialist (SASs)and those who were without expertise.A single center retrospective review 232 underwent acute surgery for AADA was conducted between 2005 2020. The cohort divided into on SASs (Group A, n = 186)...
Preoperative frailty may predispose patients to poorer outcomes in cardiac surgery; however, there are limited data concerning how preoperative predicts patient-centred outcomes, such as patient-reported disability. Our objective was evaluate the association between and postoperative disability.Patients were prospectively evaluated using Comprehensive Assessment of Frailty score, separating into frail non-frail cohorts. Disability levels quantified WHO Schedule (WHODAS) 2.0 percentage...
Macrophage migration and infiltration is an important first step in many pathophysiological processes, particular inflammatory diseases. Redox modulation of the migratory signalling processes has been reported endothelial cells, vascular smooth muscle cells fibroblasts. However redox process macrophages that from NADPH oxidase-2 (Nox2) dependent ROS not established. To investigate potential role Nox2 response macrophages, bone marrow derived were obtained WT NOX2 knockout mice (Nox2KO)...
Despite the increasing number of device implants worldwide, little is known about early and late complications cardiac resynchronisation therapy (CRT) or incidence these in patients with different heart failure aetiologies. We aim to determine procedural success CRT patients. All (<90 days) (>90 occurring over 490 consecutive procedures 402 patients, from a large single-centre registry between 2000 2009 were analysed. Mean follow-up duration was 1012 ± 610 days. In addition, data long-term...
<h3>Objective</h3> The effects of cardiovascular risk factors on the vascular anatomy at differing sites arterial vasculature have not been well described. aim this study was to compare effect intima media thickness (IMT) wall right and left common carotid artery (CCA) their bifurcation proximal from bifurcation, presence plaque femoral arteries. <h3>Design</h3> Cross-sectional population-based study. <h3>Setting/participants</h3> Random samples men (n=425) women (n=367) aged 56–77 years...
Purpose To investigate a very small iron‐oxide particle (VSOP) in mouse model of acute ischemia‐reperfusion to access the mechanism such particles areas myocardial inflammation. Materials and Methods Animals were injected with VSOP at several time points, infarction (MI), before after MI. MRI was used localize enhancement, evaluate extension, determine related T2* values. Histology, electron microscopy, macrophage counting, Evan's Blue staining also performed. Results We found that uptake...
Synovial sarcoma comprises approximately 10% of all soft tissue tumors. Primary cardiac synovial is exceedingly rare and accounts for <1% primary These tumors are highly aggressive with survival <1 year, even surgery, chemotherapy, or radiation. We describe the case a 45-year-old gentleman heart, metastasizing to lung. The tumor was resected, patient underwent chemotherapy regression lung nodules.
Background We explored the hypothesis that increased cholinergic tone exerts its proarrhythmic effects in Brugada syndrome (BrS) through increasing dispersion of transmural repolarization patients with spontaneous and drug-induced BrS. Methods BrS supraventricular tachycardia were studied after deploying an Ensite Array right ventricular outflow tract a Cardima catheter great cardiac vein to record endo epicardial signals, respectively. S1-S2 restitution curves from apex conducted at...
Carcinoid heart disease (CHD) is common in patients with carcinoid syndrome (CS). Surgical treatment improves the poor prognosis of CHD, although reported peri-operative mortality high (∼17%). We attempted to improve outcomes by implementation a protocol for management CHD at UK Neuroendocrine Centre Excellence and report our experience.All treated between 2008 2015 were included. Peri-operative included surgical features such as invasive pulmonary valve (PV) inspection preservation...
Angiosarcomas of the pulmonary artery are rare and carry a very poor prognosis. We describe case patient with angiosarcoma who underwent radical resection followed by chemotherapy was alive after 6 years follow-up. Our demonstrates that multidisciplinary approach including cardiac diagnostics, surgery, effective adjuvant chemoradiotherapy can improve outcome.
Abstract Bioglue which constitutes albumin cross linked with glutaraldehyde (ACLG) produced by Cryolife, Inc, Kennesaw, GA was introduced as a better alternative to GRF glue less tissue necrosis. We report case of 69-year-old male who developed stenosis his saphenous vein and internal thoracic artery bypass grafts, requiring re-do coronary grafting. Both fibrotic narrowing were in close proximity the site application appears be reaction glue. The advent ACLG has facilitated surgery; however,...