A5050630982- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Acupuncture Treatment Research Studies
- Craniofacial Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Folate and B Vitamins Research
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Music Perception
- Schizophrenia research and treatment
- Cell death mechanisms and regulation
- Ureteral procedures and complications
- Hereditary Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- NF-κB Signaling Pathways
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2020-2025
University of Naples Federico II
1991-2024
University of Salerno
2021
University of Perugia
2010-2020
Azienda Ospedaliera di Perugia
2015-2018
Azienda Ospedaliera Sant'Andrea
2018
Ospedale Santa Maria
2012-2017
Fondazione Santa Lucia
2012-2013
Istituti di Ricovero e Cura a Carattere Scientifico
2013
Cliniques Universitaires Saint-Luc
2009
Cladribine administration has been approved for the treatment of relapsing-remitting multiple sclerosis (MS) in 2017; thus, data on cladribine a real-world setting are still emerging.We report effectiveness, safety profile, and response predictors 243 patients with MS followed at eight tertiary centers. Study outcomes were: (1) No Evidence Disease Activity-3 (NEDA-3) status its components (absence clinical relapses, MRI activity, sustained disability worsening); (2) development grade III/IV...
Background: Little is known about COVID-19 course and outcomes after a third booster dose of mRNA vaccine against SARS-CoV-2 (mRNA-Vax) in patients with multiple sclerosis (pwMS) treated ocrelizumab (OCR) fingolimod (FNG), which showed weakened immune response to mRNA-vax. Objectives: The aim this study was evaluate pwMS on OCR FNG receiving the mRNA-Vax compare it natalizumab (NTZ). Methods: Inclusion criteria: >18 years age, being OCR/FNG/NTZ since first dose; mRNA-Vax; no steroids use....
Backgroundin the early stages of Multiple Sclerosis (MS), initiating high-efficacy disease-modifying therapy (HE DMTs) may represent an optimal strategy for delaying neurological damage and long-term disease progression, especially in highly active MS patients (HAMS). Natalizumab (NAT) Ocrelizumab (OCR) are recognized as HE DMTs with significant anti-inflammatory effects. This study investigates NEDA-3 achievement treatment-naïve HAMS receiving NAT or OCR over three years.Methodswe...
Abstract In the past few years, wine industry has shown an increasing interest in sustainability issues. There is growing agreement that circular economy solutions are essential for achieving United Nations Sustainable Development Goals (SDGs). Implementing strategies can enhance environmental and economic of production processes. this context, waste valorisation industrial symbiosis widely discussed strategies. However, there a gap between theory actual practical implementation. The present...
Neuromyelitis optica (NMO) is a demyelinating disease of the CNS that preferentially affects optic nerve and spinal cord.[1][1] The presence circulating autoantibodies (NMO–immunoglobulin G [IgG]) having water channel aquaporin-4 (AQP-4) as their target antigen associated with NMO.[1
Cognitive impairment is very frequent during multiple sclerosis (MS), involving approximately 40–70% of the patients, with a profound impact on patient's life. It now established that among various central nervous system (CNS) structures involved course MS, hippocampus particularly sensitive to detrimental effects neuroinflammation. Different studies demonstrated hippocampal involvement in association depression and cognitive impairment, such as verbal visuo-spatial memory deficits, even...
Urinary symptoms associated with multiple sclerosis (MS) are common and negatively impact on quality of life, representing a considerable psychosocial economic burden, often requiring care hospitalization. Although the importance identifying adequately treating urinary in MS is now well recognized, there no information, to date, about real prevalence bladder patients clinically isolated syndromes (CISs) suggestive MS.The aim present study was investigate, cohort diagnosis CIS MS, tract...
Tumefactive multiple sclerosis (TuMS) (i.e., MS onset presenting with tumefactive demyelinating lesions [TDLs]) is a diagnostic and therapeutic challenge. We performed multicentre retrospective study to describe the clinical characteristics prognostic factors of TuMS.One hundred two TuMS patients were included in this study. Demographic, clinical, magnetic resonance imaging (MRI), laboratory data treatment choices collected.TuMS was found affect women more than men (female:male: 2.4), young...
Background: The elucidation of mechanistic aspects relapsing–remitting multiple sclerosis (RRMS) pathogenesis may offer valuable insights into diagnostic decisions and medical treatment. Results: Two lysosomal proteases, cathepsins S D (CatS CatD), display an exclusive pattern expression in CD34 + hematopoietic stem cells (HSCs) from peripheral blood acute MS (A-MS) patients ( n = 20). While both enzymes normally exist as precursor forms the HSCs healthy individuals 30), same A-MS...
Pivotal trials showed the effectiveness of monoclonal antibody ocrelizumab in relapsing and progressive multiple sclerosis (MS). However, data on everyday practice MS patients markers treatment are scarce. We aimed to collect real-world from ocrelizumab-treated patients, relapsing-remitting (RR) (PMS), including active secondary (aSPMS) primary (PPMS) explore potential prognostic factors clinical outcome. Patients were enrolled at centres Campania region, Italy. collected clinic-demographic...
Abstract Objective Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk course. This multicentre, case–control study involving 18 Italian MS Centres investigated course by ethnicity native-country economic status foreign-born patients living Italy. Methods We identified 457 who migrated to Italy 893 age- sex-matched native-born patients. In our population, 1225 (93.2%) subjects were White Europeans Northern Americans (WENA)...
The etiology of multiple sclerosis (MS) is still largely unknown and it has been proposed that an impaired venous drainage from the central nervous system, defined as chronic cerebrospinal insufficiency (CCSVI), may play a role in this. We investigated prevalence extracranial pattern alterations cohort MS patients based on 2011 revised diagnostic criteria for CCSVI. Thirty-nine 18 healthy subjects underwent blinded extra-cranial echo-color Doppler sonography to reveal presence There was no...