A5052012778- RNA Interference and Gene Delivery
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Nanowire Synthesis and Applications
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Calcium signaling and nucleotide metabolism
- T-cell and B-cell Immunology
- Multiple Myeloma Research and Treatments
- Nanoplatforms for cancer theranostics
- Viral Infectious Diseases and Gene Expression in Insects
- Genetic and Kidney Cyst Diseases
- Micro and Nano Robotics
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
Cornell University
2023-2025
Memorial Sloan Kettering Cancer Center
2015-2025
Kettering University
2023-2024
Tel Aviv University
2016-2017
We synthesized "mesoscale" nanoparticles, approximately 400 nm in diameter, which unexpectedly localized selectively renal proximal tubules and up to 7 times more efficiently the kidney than other organs. Although nanoparticles typically localize liver spleen, modulating their size opsonization potential allowed for stable targeting of kidneys through a new proposed uptake mechanism. Applying this strategy, we anticipate use treatment disease study physiology.
Abstract Multiple myeloma (MM) is a cancer of differentiated plasma cells that occurs in the bone marrow (BM). Despite recent advancements drug development, most patients with MM eventually relapse and disease remains incurable. RNA therapy delivered via lipid nanoparticles (LNPs) has potential to be promising treatment, however, its clinical implementation limited due inefficient delivery non‐hepatic tissues. Here, targeted (t)LNPs designed for payload are presented. The tLNPs consist novel...
Immunotherapy has a great potential in advancing cancer treatment especially light of recent discoveries and therapeutic interventions that lead to complete response specific subgroups melanoma patients. By using the body's own immune system it is possible not only specifically target eliminate cells while leaving healthy unharmed, but also elicit long-term protective response. Despite promise, current immunotherapy limited fails addressing all tumor types. This probably due fact single...
Latent viral infections rely on a precise coordination of the immune response to control sporadic reactivation. CD8+ T cells play crucial role in controlling latency by generating diverse memory responses an epitope-specific manner. Among these distinct responses, conventional and inflationary have been described during herpesvirus infections. Using newly generated TCR transgenic mouse strain, we investigated transcriptomic epigenetic remodeling CMV infection across tissues at both...
Abstract Resistance to chimeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms including antigen-loss escape and tumor-induced immune suppression. Expression of CARs may overcome multi-antigen-loss escape. Similarly, expression switch receptors that convert inhibitory checkpoint signals into positive costimulatory enhance CAR activity in the tumor microenvironment. Engineering features one product, however, is limited by transgene packaging constraints current...