A5063546124- Advanced Radiotherapy Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Retinoids in leukemia and cellular processes
- Head and Neck Cancer Studies
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- IL-33, ST2, and ILC Pathways
- interferon and immune responses
- Radiomics and Machine Learning in Medical Imaging
Memorial Sloan Kettering Cancer Center
1997-2025
Abstract The AML1 gene encodes several transcription factors, including AML1A and AML1B, which bind to DNA via a TGT/cGGT consensus sequence that is found in promoters, the human IL-3 promoter. We performed cotransfection experiments T cells, demonstrated although lacks putative transactivation domain, it can transactivate promoter nearly as effectively known activator. A binding site (TGTGGT), located previously identified DNase I footprint region of (extending from bp -165 -128), similar...
Abstract Natural killer (NK) cells are innate lymphocytes that exhibit adaptive traits particularly evident during cytomegalovirus (CMV) infection. Following mouse CMV (MCMV) infection, NK upregulate the transcription factors IRF4 and IRF8, which indispensable for their survival proliferation upon viral However, it is unclear whether these expressed within same individual cell deficiency in one could be compensated by other. In this study, we observed a subset of co-express high levels IRF8...
Latent viral infections rely on a precise coordination of the immune response to control sporadic reactivation. CD8+ T cells play crucial role in controlling latency by generating diverse memory responses an epitope-specific manner. Among these distinct responses, conventional and inflationary have been described during herpesvirus infections. Using newly generated TCR transgenic mouse strain, we investigated transcriptomic epigenetic remodeling CMV infection across tissues at both...
Purpose: evaluate a commercial synthetic CT (syn-CT) software for use in prostate radiotherapy Methods: Twenty patients underwent and MR simulation scans treatment position on 3T Philips scanner. The protocol consisted of T2w turbo spin-echo soft tissue contrast, 2D balanced-fast field echo (b-FFE) fiducial identification, dual-echo 3D FFE B0 map distortion analysis mDIXON sequence to generate syn-CT. Two echoes are acquired during scan, allowing water, fat, in-phase images be derived using...
Purpose: Investigate the feasibility of using weekly MRI to assess dose organs at risk utilizing deformable image registration. Methods: Sixteen H&N patients with oropharyngeal cancer were imaged on a 3T MR scanner T2W and mDIXON sequence. Patients basis in treatment position. Parotids (LP & RP), submandibular glands (LS, RS), oral cavity (OC) delineated reviewed by board certified radiation oncologist. The original planning CT (pCT), RT‐Dose, RT‐Structures deformed registered each...