Nicole Tamvaka
A5002104222- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Neurogenetic and Muscular Disorders Research
- Genetic Associations and Epidemiology
- Prion Diseases and Protein Misfolding
- Dementia and Cognitive Impairment Research
- Neurotransmitter Receptor Influence on Behavior
- RNA modifications and cancer
- Neurological disorders and treatments
- RNA regulation and disease
- Metabolism and Genetic Disorders
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Biological Research and Disease Studies
- GDF15 and Related Biomarkers
Mayo Clinic in Florida
2022-2025
Dickinson College
2024
Jacksonville College
2022-2024
WinnMed
2022-2024
BackgroundPick's disease is a rare and predominantly sporadic form of frontotemporal dementia that classified as primary tauopathy. Pick's pathologically defined by the presence in frontal temporal lobes Pick bodies, composed hyperphosphorylated, three-repeat tau protein, encoded MAPT gene. has two distinct haplotypes, H1 H2; haplotype major genetic risk factor for four-repeat tauopathies (eg, progressive supranuclear palsy corticobasal degeneration), H2 protective these disorders. The aim...
Pick’s disease (PiD) is a rare neurodegenerative disorder defined by dementia, frontotemporal lobe atrophy, and 3-repeat tau inclusions. To elucidate PiD pathobiology, we performed the first bulk transcriptomics study on using short- long-read sequencing parietal cortex of 28 15 control samples. We identified several significantly differentially expressed genes, with CCL2 displaying strongest association pathology increased burden in compared to those 4-repeat progressive supranuclear palsy...
Abstract Background Pick’s disease (PiD) is a rare and predominantly sporadic form of frontotemporal dementia that classified as primary tauopathy. PiD pathologically defined by argyrophilic inclusion Pick bodies ballooned neurons in the frontal temporal brain lobes. characterised presence which are formed from aggregated, hyperphosphorylated, 3-repeat tau proteins, encoded MAPT gene. The H2 haplotype has consistently been associated with decreased risk 4-repeat tauopathies progressive...
Abstract Background Given the overlap of symptoms between Alzheimer’s disease (AD) and other dementias, it is essential to develop widely accessible biomarkers that will ensure an accurate diagnosis AD enable its proper treatment. African Americans (AA) are twice more likely than non‐Hispanic whites (NHW) yet they remain underrepresented in research. The few studies conducted AA suggest there different factors influence this population; therefore, possible and/or therapies may be needed...
Abstract Background We recently discovered a novel tau binding partner, SERPINA5, to be upregulated in Alzheimer’s disease (AD) and co‐localize with corticolimbic distribution. As pathology is also observed primary tauopathies, we hypothesized that SERPINA5 burden would mirror these diseases. Thus, sought define the relationship between tauopathies compare this AD. Method Immunohistochemistry was performed on hippocampus or cingulate 4 groups (n=6 per group): 1) AD, 2) 3R+4R age‐related...