A5083401160- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Acute Myeloid Leukemia Research
- Cutaneous lymphoproliferative disorders research
- Chronic Lymphocytic Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Inflammasome and immune disorders
- T-cell and Retrovirus Studies
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Single-cell and spatial transcriptomics
- PI3K/AKT/mTOR signaling in cancer
- Immune Response and Inflammation
- Pancreatic function and diabetes
- 14-3-3 protein interactions
- Phytochemical compounds biological activities
- Vector-Borne Animal Diseases
- interferon and immune responses
- Autoimmune and Inflammatory Disorders
- Multiple Myeloma Research and Treatments
- Peatlands and Wetlands Ecology
- Bryophyte Studies and Records
- Phagocytosis and Immune Regulation
- CRISPR and Genetic Engineering
- Lung Cancer Treatments and Mutations
- Ubiquitin and proteasome pathways
Boston Children's Hospital
2015-2024
Boston Children's Museum
2024
Harvard University
2015-2019
University of Virginia
2019
Northwestern University
2010-2015
Fordham University
2014
Broad Institute
2009-2012
Individuals with Down syndrome (DS; also known as trisomy 21) have a markedly increased risk of leukemia in childhood but decreased solid tumors adulthood. Acquired mutations the transcription factor–encoding GATA1 gene are observed nearly all individuals DS who born transient myeloproliferative disorder (TMD), clonal preleukemia, and/or develop acute megakaryoblastic (AMKL). do not bear germline analogous to those detected TMD and DS-AMKL predisposed leukemia. To better understand...
RIPK1-dependent necroptotic cell death stimulates neutrophil NET formation to control MRSA infection.
Bryophytes can strongly influence biodiversity and ecosystem function in low-order streams. Mosses liverworts have substantial biomass streams, yet few investigators examined which factors bryophyte species distributions, fewer assemblages across a wide pH gradient. We gradient 26 southeastern New York (USA) recorded richness, diversity, abundance, conjunction with pH, width, depth, canopy cover, substratum size, temperature, dissolved O2, turbidity, conductivity, current velocity, organic...
// Marco Colamonici 1,2 , Gavin Blyth Diana Saleiro Amy Szilard Meghan Bliss-Moreau 1 Francis J. Giles Jessica K. Altman 1,2,3 Elspeth M. Beauchamp and Leonidas C. Platanias Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA 2 Division Hematology-Oncology, Department Medicine, Feinberg School 3 Jesse Brown VA Medical Center, Correspondence to: Platanias, email: Keywords : AML, mTOR signaling, PI3 kinase Received January 01, 2015 Accepted February 03,...
The commitment of hematopoietic stem cells (HSC) to myeloid, erythroid, and lymphoid lineages is influenced by microenvironmental cues, governed cell-intrinsic epigenetic characteristics that are unique the HSC population. To investigate nature lineage bias in human HSC, mitochondrial single cell (sc) ATAC-Sequencing (mt-scATACSeq) was used identify somatic mutations DNA act as natural genetic barcodes for tracking ex vivo differentiation potential mature cells. Clonal CD34+ their progeny...
Abstract Cutaneous T-Cell Lymphomas (CTCL) represent a heterogeneous group of hematopoietic malignancies that account for 5-10% Non-Hodgkin Lymphomas. The initial disease presentation is characterized by the infiltration skin malignant clonal CD4+ lymphocytes possess mature memory helper T-cell phenotype. CTCL patients present in spectrum defined phenotypes, Mycosis Fungoides (MF) and Sézary Syndrome (SS) being most common. Thus, it not surprising no underlying molecular basis has been...
Abstract As many as 20% of breast cancer patients have brain metastases, with women surviving only 2-16 months after diagnosis this metastasis. Thus, resolving the mechanisms metastasis to is clinically important. In invasive carcinomas, Syndecan (Sdc) 1 observed in stromal fibroblasts and endothelial cells where it involved tumor growth angiogenesis. Staining for Sdc1 both has been reported be a negative predictor disease free overall survival estrogen receptor (ER) tumors, expression 4...
Abstract Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by sterile infiltrates neutrophils. These syndromes include pyoderma gangrenosum (PG) and Sweet’s syndrome (SS), they associated with an increased incidence bowel disease, rheumatoid arthritis, acute myeloid leukemia. IL-1β is detectable in lesions, IL-1 neutralizing therapies have met success some patients. Splicing variants promoter region deletions protein tyrosine phosphatase-6 (PTPN6) feature SS...