A5101694286- Lung Cancer Treatments and Mutations
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Acute Myeloid Leukemia Research
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cancer Genomics and Diagnostics
- Assistive Technology in Communication and Mobility
- Inflammatory Biomarkers in Disease Prognosis
- Salivary Gland Tumors Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Forensic and Genetic Research
- Ubiquitin and proteasome pathways
- Cancer survivorship and care
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Blood disorders and treatments
- Protein Degradation and Inhibitors
- Erythrocyte Function and Pathophysiology
- Stroke Rehabilitation and Recovery
- Biosimilars and Bioanalytical Methods
- Genetic and Kidney Cyst Diseases
National Cheng Kung University Hospital
2021-2025
Washington University in St. Louis
2025
Institute of Statistical Science, Academia Sinica
2017-2024
Linkou Chang Gung Memorial Hospital
2014-2020
China Medical University
2011-2019
Palo Alto University
2018
Stanford University
2018
China Medical University Hospital
2011-2018
Chang Gung University
2012-2014
National University of Tainan
2014
Summary VISTA is a key immune checkpoint receptor under investigation for cancer immunotherapy; however, its signaling mechanisms remain unclear. Here we identify conserved four amino acid (NPGF) intracellular motif in that suppresses cell proliferation by constraining cell-intrinsic growth signaling. The NPGF binds to the adapter protein NUMB and recruits Rab11 endosomal recycling machinery. We characterize class of triple-negative breast cancers with high expression low proliferative...
Abstract Objective This study aimed to examine changes in physical symptom severity, functional status, supportive care needs, and related factors oral cavity cancer patients during 6 months after beginning radiation therapy (RT) or concurrent chemotherapy (CCRT). Methods A prospective longitudinal was conducted involving from an RT clinic at a medical center northern Taiwan. Patients were assessed for needs symptoms five time points: before the of CCRT 1, 2, 3, CCRT. The generalized...
Objectives/Hypothesis The benefits of elective neck dissection (END) in early‐stage tongue cancer have been widely discussed but are still controversial regarding buccal cancer. In this study, we evaluate the role END and treatment outcome an areca‐quid endemic area. Study Design Retrospective case‐control study. Methods One hundred seventy‐three cT1‐2N0M0 patients all staged by computed tomography or magnetic resonance imaging were recruited. A total 151 received radical surgery with END,...
Abstract T-cell acute lymphoblastic leukemia (T-ALL) is caused by the accumulation of multiple genetic alterations. To determine frequency common mutations and possible prognostic markers in childhood T-ALL, we performed targeted sequencing 67 genes across 64 cases treated according to Taiwan Pediatric Oncology Group protocols between January 2002 December 2015. Together, 302 variants were identified 60 including 233 single nucleotide 69 indels. Sixty-four samples had a median number six...
Background: Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. In Asian populations, epidermal growth factor receptor (EGFR) mutations are particularly prevalent, to development EGFR tyrosine kinase inhibitors (TKIs) improve patient outcomes. While extensive research has been conducted on prognosis patients receiving EGFR-TKIs, estimation 5-year survival in this population remains an underexplored area. Objectives: This study aimed provide...
ABSTRACT Advanced‐stage EGFR‐mutated lung non‐small cell cancer (NSCLC) challenges current treatment paradigms, particularly after frontline EGFR‐TKI therapy failure. This study investigates the survival impact of combined anti‐angiogenic agent and immunochemotherapy (AICT) for this population. We retrospectively analyzed NSCLC patients at National Cheng Kung University Hospital from January 2010 to December 2022, focusing on those who had disease progression beyond treatments. Survival...
The genomic landscape of breast cancer (BC) is complex. purpose this study was to decipher the mutational profiles Taiwanese patients with BC using next-generation sequencing. We performed whole-exome sequencing on DNA from 24 tumor tissue specimens patients. Sanger used validate identified variants. also paired adjacent nontumor tissues. After genotype calling and algorithmic annotations, we 49 deleterious variants in canonical cancer-related genes our cohort. most frequently mutated were...
Abstract Objectives To investigate the prognostic value of preoperative systemic immune‐inflammation index (SII) in patients with oral cavity squamous cell carcinoma (OC‐SCC) treated curative surgery followed by adjuvant radiotherapy (RT) or chemoradiotherapy (CCRT). Materials and Methods We retrospectively reviewed clinical records OC‐SCC who received postoperative RT/CCRT between January 2005 December 2012. Blood samples were drawn 2 weeks preceding surgery. SII was calculated multiplying...
Targeted therapy with combined dabrafenib and trametinib has been proven to provide clinical benefits in patients NSCLC a
Invasive pulmonary aspergillosis (IPA) can negatively impact cancer patients' survival. It remains uncertain whether IPA's on patient outcomes varies by treatment approach in advanced lung cancer.To explore the association between IPA and patients with receiving different treatments.A retrospective cohort study.We enrolled advanced-stage 2013 2021 at a college hospital Taiwan used European Organization for Research Treatment of Cancer/Mycoses Study Group Education Consortium consensus...
Hemoglobin (Hb) gene disorders are common inherited diseases in Taiwan. The α- and β-thalassemias among the well-known Hb this area. We reviewed abnormal hematological data 3578 cases, identified between 1998 2009, as being at-risk for α-thalassemia (α-thal) (n = 1909; 53.3%), β-thal 743; 20.8%), non-α, 872; 24.4%), α-thal combined with 54; 1.5%), collected fetal blood samples prenatal testing. most types of α0- α+-thal were SEA (Southeast Asian) deletion −α3.7 rightward deletion,...
Abstract Background This study analyzed data from two consecutive protocols for children newly diagnosed with acute lymphoblastic leukemia (ALL) to determine the clinical impact of minimal/measurable residual disease (MRD) and recently identified tumor genetic subtypes. Methods Genetic subtypes were determined by sequential approaches including DNA indexing, reverse transcriptase–polymerase chain reaction, multiplex ligation‐dependent probe amplification, RNA‐sequencing. MRD was assessed...
Background Janus kinase 2 ( JAK2 ) plays an important role in normal hematopoietic growth factor signaling. The detection of the V617F mutation (c.1849GNT, GTC → TTC) is crucial for diagnosis myeloproliferative neoplasm (MPN) and has become essential criteria MPN by WHO. High‐resolution melt (HRM) curve analysis a nongel‐based, closed‐tube method, which PCR amplification subsequent are sequentially performed well, making it more convenient than other scanning methodologies. Methods We...
Telisotuzumab vedotin is a MET-targeting antibody-drug conjugate that has demonstrated good treatment response in patients with EGFR wild-type MET-overexpressing non-squamous non-small cell lung cancer. However, have been reported to acquire resistance this drug, and the subsequent therapy not standardized. Here, we present case of 56-year-old woman diagnosed KIF5B-MET fusion-positive cancer who had durable capmatinib after acquired telisotuzumab vedotin.
Abstract The role of Programmed Cell Death Ligand 1 (PD-L1) expression in predicting epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKIs) efficacy remains controversial. Recent studies have highlighted that tumor-intrinsic PD-L1 signaling can be modulated by STAT3, AKT, MET oncogenic pathway, epithelial–mesenchymal transition, or BIM expression. This study aimed to investigate whether these underlying mechanisms affect the prognostic PD-L1. We retrospectively enrolled...
Although combination therapy including chemotherapy and immune checkpoint inhibitors (ICIs) improves overall survival (OS) of patients with non-small-cell lung cancer (NSCLC), there is a higher incidence adverse events treatment discontinuation. Since programmed death-ligand 1 (PD-L1) could not serve as predictive biomarker, we investigated the neutrophil-to-lymphocyte ratio (NLR) biomarker. In our previous research, demonstrated that low NLR predict benefits when high PD-L1 expression (>...
The study focus on using interactive teaching materials to investigate the intervention phrase for child with severe cerebral palsy, single subject experimental method as method, experiment process located at elementary resource classroom. This set up target behavior from participant's parents and therapists, I II are training effectiveness evaluation via Wiimote materials. of lifting height upper arm, reaction time hand straight forward press, fingers grasping ability. results show that...
Purpose: To investigate the potential value of concurrent chemotherapy in patients with salivary gland carcinomas treated postoperative radiotherapy (PORT). Materials and Methods: This retrospective review included 167 consecutive major minor from 2001 to 2011. All were curative surgery followed by PORT (n=93) or chemoradiotherapy (POCRT) (n=74). The median cumulative radiation doses 66 Gy for both groups, cisplatin-based chemotherapies most commonly used regimens. Results: follow-up was 5.4...
Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants intolerance, especially the Asian population. Two variants, c.55_56insGAGTCG exon 1 and c.415C > T 3, were commonly detected same allele, named NUDT15*1/*2. Although rare, compound heterozygous mutations also occur, two on different alleles (NUDT15*3/*6), which may confer tolerance to considerably...
Abstract Background Some prospective studies have shown that second‐generation tyrosine kinase inhibitors (TKIs) provide better control in patients with non‐small cell lung cancer (NSCLC) uncommon epidermal growth factor receptor ( EGFR ) mutations. However, comparing second‐line chemotherapy efficacy between NSCLC common and mutations remain rare. This retrospective study compared treatment outcomes these patients. Methods Patients ‐mutated advanced‐stage who received first‐line EGFR‐TKIs a...