A5101608489- RNA modifications and cancer
- Urinary Bladder and Prostate Research
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Prostate Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Genetic Mapping and Diversity in Plants and Animals
- RNA Research and Splicing
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Epigenetics and DNA Methylation
- Hormonal and reproductive studies
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- Asian Culture and Media Studies
- Nanoparticle-Based Drug Delivery
- Human Pose and Action Recognition
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Retinoids in leukemia and cellular processes
- Kruppel-like factors research
- Histone Deacetylase Inhibitors Research
- Lipid metabolism and biosynthesis
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
Linyi University
2024
Jiangnan University
2022-2023
Wuxi Fourth People's Hospital
2023
Peking University
2009-2023
University of North Carolina at Charlotte
2014-2015
Wake Forest University
2012-2013
Guangdong Pharmaceutical University
2013
Human de novo genes can originate from neutral long non-coding RNA (lncRNA) loci and are evolutionarily significant in general, yet how why this all-or-nothing transition to functionality happens remains unclear. Here, 74 human/hominoid-specific genes, we identified distinctive U1 elements splice-related sequences accounting for nuclear export, differentiating mRNAs lncRNAs, driving the origin of lncRNA loci. The polymorphic sites facilitating lncRNA-mRNA conversion through regulating export...
Abstract Background Long noncoding RNAs (lncRNAs) have driven research focused on their effects as oncogenes or tumor suppressors involved in carcinogenesis. However, the functions and mechanisms of most lncRNAs colorectal cancer (CRC) remain unclear. Methods The expression DLGAP1-AS2 was assessed by quantitative RT-PCR multiple CRC cohorts. impacts growth metastasis were evaluated a series vitro vivo assays. Furthermore, underlying mechanism revealed RNA pull down, immunoprecipitation,...
Ovarian cancer is a deadly female reproductive cancer. Understanding the biological mechanisms underlying ovarian could help lead to quicker and more accurate diagnosis effective treatments. Both changes in microRNA(miRNA) expression miRNA/mRNA dysregulation have been associated with With availability of whole-genome miRNA mRNA sequencing we now new potentials study these associations. In this study, performed comprehensive analysis using an integrative network approach combined association...
Abstract Hyperplasia suppressor gene (HSG), also called human mitofusin 2, is a novel that markedly suppresses the cell proliferation of hyperproliferative vascular smooth muscle cells from spontaneously hypertensive rat arteries. This encodes mitochondrial membrane protein participates in fusion and contributes to maintenance operation network. In this report, we showed an adenovirus vector encoding HSG (Ad5-hHSG) had antitumor activity wide range cancer lines. We further focused on lung...
Common treatments for benign prostatic hyperplasia include 5α-reductase inhibitors and α-adrenergic receptor antagonists. However, these can only partially decrease the risk of progression. SRD5A1 SRD5A2 are inhibitor targets. We investigated association between drug efficacy single nucleotide polymorphisms in genes a Chinese population.We genotyped 11 tagging total 426 cases 1,008 controls from Xinhua Hospital, Shanghai, People's Republic China. Cases were treated with type II tested...
Gene expression is a critical process in biological system that influenced and modulated by many factors including genetic variation. Expression Quantitative Trait Loci (eQTL) analysis provides powerful way to understand how variants affect gene expression. For genome wide eQTL analysis, the number of genes are large thus search space tremendous. Therefore, brings about computational statistical challenges. In this paper, we provide comprehensive review recent advances methods for...
A recent Genome-Wide Association study (GWAS) identified rs11984041 on HDAC9 gene to be significantly associated with stroke in a Caucasian population. However, whether also plays role other ethnicities is unknown. The current was conducted investigate the association of single nucleotide polymorphisms (SNPs) and risk Chinese Sixteen tagging SNPs for were genotyped population 279 cases 984 controls from Changhai Hospital Shanghai, China. candidate region investigated haplotype block located...
BACKGROUND Benign prostatic hyperplasia (BPH) is a common disease prevalent in elderly men. However, the genetic determinants of BPH remain unclear. Because and prostate cancer (PCa) share some pathological characteristics, we investigated whether susceptibility loci for PCa contributed to risk aggressiveness Chinese METHODS Fourteen SNPs associated with population were genotyped 426 cases (184 aggressive 242 non-aggressive cases) 1,008 controls. The association between risk/aggressiveness...
A recent prostate cancer (PCa) genome-wide association study (GWAS) identified rs103294, a single nucleotide polymorphism (SNP) located on LILRA3, key component in the regulation of inflammatory inhibition, to be significantly associated with PCa risk Chinese population. Because inflammation may common etiological factor between and benign prostatic hyperplasia (BPH), current was conducted investigate rs103294 BPH risk. genotyped population 426 cases 1,008 controls from Xinhua Hospital...
Labeling children's play behavior is an important process in social analysis which traditionally done by experienced coders. With the growing volume of data, automatic methods for labeling are increasingly required. This paper presents a novel method to label automatically peer-play scenarios based on visual attention and mutual interaction computation. In this method, discrete distribution computed face pose estimation. Then, among children calculated "Attention Processes", continuous...
Elongin A (ELOA), our previous work revealed, serves as a novel tumor suppressor in colorectal cancer. However, the function and mechanism of ELOA other cancer types, including gastric (GC), remain to be elucidated.The expression was measured by quantitative reverse transcription-polymerase chain reaction western blot. The effects on GC growth metastasis were assessed through series in-vitro in-vivo assays. Furthermore, potential revealed RNA sequencing, dual luciferase reporter assay,...
Therapeutic approaches of combining various treatments have appealed intensive interests for tumor therapy. Nevertheless, these strategies remain suffered from many obstacles the intricate microenvironment (TME, e.g. over-expressed GSH,...