High mobility group box-1 (HMGB1) is a factor regulating malignant tumorigenesis, proliferation, and metastasis, associated with poor clinical pathology in various human cancers. We investigated the differential concentrations of HMGB1 tissues sera, their value for diagnosis patients breast cancer, benign disease, healthy individuals.HMGB1 levels tumor tissues, adjacent normal disease was detected via immunohistochemistry. Serum measured using an enzyme-linked immunosorbent assay 56 25 30...

Abstract Background Chronic cough is a common symptom in patients post the coronavirus disease 2019 (COVID-19). In this study, we aimed to investigate efficacy of inhaled corticosteroids (ICS) and clinical characteristics with post-COVID-19 chronic during Omicron era. Methods An ambispective, longitudinal cohort study was conducted that included who attended respiratory clinic at our hospital between January 1, 2023, March 31, 2023 complaint persistent lasting more than 8 weeks. At 30 60...

In light of the absence rapid and precise diagnostic laboratory tests for detection Mycoplasma pneumoniae (MP), a prominent etiological agent implicated in range respiratory infections, we developed evaluated straightforward loop-mediated isothermal amplification (LAMP) assay targeting MP community-acquired distress syndrome toxin (CARDS TX) gene. The LAMP was performed at 65°C duration 60 min, yielding minimum concentration CARDS TX 0.4986 pg/μl. exhibited no cross-reactivity with 13 other...

ABSTRACT Macrolide resistance in Mycoplasma pneumoniae is becoming prevalent. Tetracyclines are an important alternative for patients with macrolide-resistant M. infections. Tetracycline-resistant has never been reported clinical isolates or vitro -induced strains. Here, we aimed to explore tetracycline-resistant and the underlying mechanisms. Clinically isolated parental strains were selected tetracycline by inducing them increasing concentrations of tetracycline, minocycline, tigecycline....

Hypoxia-responsive miRs have been frequently reported in the growth of various malignant tumors. The present study aimed to investigate whether hypoxia-responsive miR-141-3p was implicated pathogenesis breast cancer via mediating high-mobility group box protein 1 (HMGB1)/hypoxia-inducible factor (HIF)-1α signaling pathway.miRs expression profiling filtrated by miR microarray assays. Gene and levels, respectively, were examined a quantitative reverse transcriptase-polymerase chaion reaction...

Abstract Background Vasculopathy underlies diabetic complications, with perivascular adipose tissue (PVAT) playing crucial roles in its development. However, the changes cellular composition and function of PVAT, including specific cell subsets mechanisms implicated type 2 diabetes mellitus (T2DM) vasculopathy, remain unclear. Methods To address above issues, we performed single-cell RNA sequencing on stromal vascular fraction (SVF) PVAT from normal T2DM rats. Then, various bioinformatics...

Nanoparticles and thyroid cancer 0.7856).No parathyroid accidental resection was observed in the carbon nanoparticle group, whereas three cases occurred control group (P = 0.2405).In conclusion, nanoparticles show good lymphatic tracer effects, easy identification, increased number of lymph nodes retrieved, more accurate reflection VI region node status, accuracy clinical stage.These results should help develop reasonable surgery programs follow-up comprehensive treatments, can to reduce...

Ibuprofenamine hydrochloride spray is novel transdermal nonsteroidal anti-inflammatory drugs (NSAIDs), under clinical development for the treatment of Rheumatoid Arthritis and Osteoarthritis as a drug.A single multiple ascending dose study investigated safety, tolerability pharmacokinetics ibuprofenamine in healthy Chinese subjects. A total 34 subjects (single-dose study: multiple-dose 20 subjects) were involved trial. In single-dose study, assigned to one four groups received 35, 70, 140,...

Osteoarthritis (OA) is a degenerative joint disease caused by many factors. Astragali Radix (Huangqi), traditional Chinese medicine (TCM), widely used to treat OA. Although it can inhibit the progression of OA, its pharmacological mechanism unclear. In this study, we network approach determine which Huangqi inhibits We obtained active ingredients from Traditional Systems Pharmacology database and identified potential targets these ingredients. Next, OA-related using GeneCards Online...

SUMMARY: BACKGROUND: Malignant peripheral nerve sheath tumors are rare tumor entities that originate from sheaths and have an unfavorable prognosis. Common sites include deeper soft tissues, usually in the proximity of a trunk. Breast is absolutely location this lesion, presentation as breast lump male even rarer. CASE REPORT: A 65-year-old man presented with 6-month history painless mass left breast. Tissue biopsy was performed. Histopathology revealed malignant spindle cell which confirmed...

To assess the clinical efficacy of minimally invasive technology with trajectory screw fixation for fragility fractures pelvic(FFP).A retrospective case control study was performed to analyze data 35 patients FFP who were treated and followed up between January 2016 December 2019. There 12 males 23 females, aged from 65 99 years an average of(75.4±7.8) old. 13 cases type Ⅱb, 7 Ⅱc, 8 Ⅲa, 2 Ⅲb, Ⅲc, 1 Ⅳb, Ⅳc according Rommens comprehensive classification. All received treatment screws fixation....

To evaluate the clinical effects of over 5 year follow up unilateral pedicle screw fixation with transforaminal lumbar interbody fusion(TLIF) in treating degenerative diseases.The data 24 patients disease underwent fusion from March 2007 to October 2009, were retrospectively analyzed. There 13 males and 11 females, aged 34 68 years old an average 52 years. Postoperative pain functional results analyzed by visual analogue scale(VAS) Oswestry Disability Index(ODI). Radiological examination was...

To develop a bioinformatic tool and to use it identify proteomic patterns in serum, distinguishing colorectal cancer from adenoma healthy individuals.182 serum samples including 55 patients, 35 92 individuals were subjected analysis by surface-enhanced laser desorption/ionization (SELDI) mass spectrometry.The diagnostic pattern combined of 4 candidate biomarkers (M/Z 5911, 8922, 8 944, 8817) could separate patients control with specificity 93.3%, sensitivity 90.9%, Youden index value...

Background: Intrathoracic displacement of a humeral head fracture is extremely rare. Only slightly more than 30 cases have been reported in this regard. Since few reported, there no consensus on how to treat injury. The etiology, injury mechanism, related lesions, and treatment the are diverse. Case presentation: A 73-year-old female presented with multiple fractures left ribs, bilateral lung contusions, extensive emphysema anterior posterior chest wall, massive hemopneumothorax,...

Objective To explore the value of application intra-operative recurrent laryngeal nerve monitoring (IONM) in lymph node dissection central area (Ⅵ area) differentiated thyroid carcinoma (DTC). Methods One hundred patients suffered from DTC were divided into group (observation group) and conventional surgery (control with fifty each. Patients observation performed IONM, as control, other control on operation without this technology, then differences several related indexes between two...

Abstract Background: Hainan Province is situated at the southernmost tip of People's Republic China, within northern tropical belt. However, risk factors for classic Kaposi's sarcoma in this region remain unknown. To explore prognostic patients with Kaposi’s (CKS) and develop a nomogram to quantitatively predict cancer-specific survival (CSS) probability. Methods: This study retrospectively analyzed clinical data 42 CKS admitted between January 1999 June 2022. Univariate analysis was...

Objective To explore the relationship between separation of proximal radioulnar joint and lesions forearm interosseous membrane (IOM) in children Monteggia fractures to evaluate our new classification based on joint. Methods The clinical data 38 with fresh fracture were collected who had been treated from October 2013 August 2015. They 24 boys 14 girls, aged 3 11 years (average, 6.9 years). According classification, there 12 cases type Ⅰ, Ⅱ, 2 Ⅲ. The MRI images New types Ⅰ Ⅱ analyzed....

Objective To evaluate the application of ultrasound-guided nerve block in elderly patients undergoing inguinal hernia surgery. Methods A retrospective analysis was carried out sixty-four male who had underwent unilateral repair under local anesthesia from June 2014 to 2016 Liaocheng People’s Hospital. Twenty-nine were group, meanwhile 35 cases anatomia located group. Clinical data including effects, dosage, operation time, pain scores, postoperative complications and recurrence rates...

Objective To evaluate the clinical application of a three-dimensional (3D) printing personalized guide for medial open wedge high tibial osteotomy(MOWHTO) in treatment knee varus osteoarthritis. Methods A retrospective study was conducted 16 patients with os-teoarthritis who had been treated at Department Orthopaedics, Zhengzhou Central Hospital University from January 2016 to 2017. They were 6 men and 10 women, aged 49 65 years (mean, 55.8 years). Bilateral knees involved 2 cases...