A5100682285- Respiratory viral infections research
- Dementia and Cognitive Impairment Research
- Hepatitis B Virus Studies
- Breastfeeding Practices and Influences
- Diet and metabolism studies
- COVID-19 Clinical Research Studies
- Acupuncture Treatment Research Studies
- SARS-CoV-2 and COVID-19 Research
- Traditional Chinese Medicine Studies
- Liver Disease Diagnosis and Treatment
- Neurological Disorders and Treatments
- Pelvic and Acetabular Injuries
- Child Nutrition and Water Access
- Global Maternal and Child Health
- Neonatal and fetal brain pathology
- Kawasaki Disease and Coronary Complications
- Gut microbiota and health
- Frailty in Older Adults
- Hip and Femur Fractures
- Long-Term Effects of COVID-19
- Neonatal Respiratory Health Research
- Bone fractures and treatments
- Birth, Development, and Health
- Osteomyelitis and Bone Disorders Research
- Artificial Intelligence in Healthcare and Education
Shanghai Jinyuan Senior High School
2025
Nationwide Children's Hospital
2021-2025
Lishui Central Hospital
2021-2024
China-Japan Friendship Hospital
2015-2024
Children's Hospital of Fudan University
2021-2024
Fourth People's Hospital of Sichuan Province
2023-2024
University of Electronic Science and Technology of China
2024
Wenzhou Medical University
2023
Zhejiang University
2023
Huazhong University of Science and Technology
2022
Despite the successful use of a ketogenic diet in pediatric epilepsy, its application adults has been limited. The aim this meta-analysis was to summarize findings relevant published studies order identify efficacy and compliance with main subtypes (i.e., classic modified Atkins diet) intractable provide useful information for clinical practice.Electronic searches PubMed, EMBASE, Google Scholar, ISI Web Science were conducted patient epilepsy; included reviewed. Meta-analyses performed using...
Adolescent idiopathic scoliosis (AIS) surgery usually require prolonged operative times with extensive soft tissue dissection and significant perioperative blood loss, allogeneic products are frequently needed. Methods to reduce the requirement for transfusion would have a beneficial effect on these patients. Although many previous studies revealed efficacy of tranexamic acid (TXA) in spinal surgery, there is still lack agreement concerning reduction both loss requirements large dose...
There are only a few cognitive screening tests for the Chinese-speaking population, and so this study aimed to validate Chinese version of Addenbrooke's Cognitive Examination III (ACE-III) detecting mild impairment (MCI) dementia. Its diagnostic accuracy was compared with versions Mini Mental State (MMSE) Montreal Assessment (MoCA).The 176 included individuals were divided into 3 groups: dementia group, MCI normal control group. MMSE, MoCA, ACE-III administered all participants by...
Differences in immune profiles of children and adults with COVID-19 have been previously described. However, no systematic studies reported from infants hospitalized severe disease. We applied a multidimensional approach to decipher the responses SARS-CoV-2 infected (n = 26; 10 subacute, 11 moderate 5 disease; median age 1.6 months) matched controls 14; 2 months). Single cell (scRNA-seq) profiling PBMCs revealed substantial alterations composition infants; most cell-types switching an...
Chiral α-functionalized α-amino ketones are sought-after compounds for drug development; however, their acyclic enantioselective synthesis with amines as nucleophiles remains challenging. The catalytic decarboxylation of propargylic cyclic carbonates through metal-allenylidene intermediates has proven to be an efficient route chiral quaternary centers, but its mechanisms require clarification. Herein, we computationally investigate the Cu(I)-catalyzed propargyl aniline [Guo, W. J. Am. Chem....
Background: In the past decades, studies on infant anemia have mainly focused rural areas of China. With increasing heterogeneity population in recent years, available information is inconclusive large cities China, especially with comparison between native residents and floating population. This population-based cross-sectional study was implemented to determine anemic status infants as well risk factors a representative downtown area Beijing. Methods: As useful methods build predictive...
Objective To assess the economic impact of maternal death on rural Chinese households during year after death. Methods A prospective cohort study matched 183 who had suffered a to 346 that experienced childbirth without in areas three provinces China. Surveys were conducted at baseline (1–3 months or childbirth) and one using quantitative questionnaire. We investigated household income, expenditure, accumulated debts, self-reported status. Difference-in-Difference (DID), linear regression,...
Amnestic mild cognitive impairment (aMCI) is a pre-dementia condition associated with declined function dominated by memory impairment. The occurrence of aMCI the gut-brain axis. Previous studies have shown improvements in MCI after acupuncture treatment. This study evaluates whether can produce therapeutic effect patients modulating axis.This prospective, parallel, multicenter randomized controlled trial. A total 40 will be randomly assigned to an group (AG) or waiting-list (WG),...
To identify the incidence of adverse events (AE) that occurred in stroke survivors during first year following discharge from inpatient rehabilitation and to determine type patterns AE.Data were collected for 12 months on resulting admissions emergency department, hospital, long-term care facility, or death. Descriptive statistics used depict AE univariate comparisons made differences between who did not experience one more AE.Of 159 participants, 50% reported a total 163 AE. Most (82.2%)...
Background/Aims: There are limited cognitive screening tests for the Chinese-speaking population. This study aimed to validate Chinese version of Mini-Addenbrooke’s Cognitive Examination (M-ACE) detecting mild impairment (MCI) and dementia. Its diagnostic accuracy was compared with that Mini-Mental State (MMSE). The also evaluated influential factors M-ACE scores its convergent validity against Clinical Dementia Rating Scale (CDR) MMSE. Method: One hundred sixty-nine participants were...
Kidney disease is manifested in a wide variety of phenotypes, many which have an important hereditary component. To delineate the genotypic and phenotypic spectrum pediatric nephropathy, multicenter registration system being implemented based on Chinese Children Genetic Disease Database (CCGKDD). In this study, all patients with kidney urological diseases were recruited from 2014 to 2020. analysis was conducted using exome sequencing for families multiple affected individuals nephropathy or...
Blood pressure (BP) variability has been shown to be an independent risk factor of stroke and target organ damage because hypertension, but so far, there have very few studies investigating the impact BP on cerebrovascular atherosclerosis.A total 409 participants were enrolled classified according patterns atherosclerosis (i.e. large or small artery atherosclerosis; extracranial; intracranial atherosclerosis). Coefficient variation (CV) was used as a marker variability. Multivariate binary...
Abstract Aims Recent evidence indicated the biological basis of complement 1q (C1q)/tumor necrosis factor (TNF)‐related protein (CTRP) 3, 4, and 14 for affecting brain structure cognitive function. Thus, we aimed to investigate association between plasma CTRPs with Alzheimer's disease (AD). Methods A multicenter, cross‐sectional study recruited patients AD ( n = 137) cognitively normal (CN) controls 140). After data collection demographic characteristics, lifestyle risk factors, medical...
Objectives Neuropsychological test batteries, which accurately and comprehensively assess cognitive functions, are a crucial approach in the early detection of interventions for impairments. However, these tests have yet to gain wide clinical application China owing their complexity time-consuming nature. This study aimed develop Computerized Neurocognitive Battery Chinese-Speaking participants (CNBC), an autorun autoscoring assessment tool provide efficient accurate evaluations individuals....
<title>Abstract</title> Differences in immune profiles of children and adults with COVID-19 have been previously described. However, no systematic studies reported from infants hospitalized severe disease. We applied a multidimensional approach to decipher the responses SARS-CoV-2 infected (n=26; 10 subacute, 11 moderate 5 severe; median age=~1.6 months) matched controls (n=14; age=~2 months). Single cell (scRNA-seq) profiling PBMCs revealed substantial alterations composition infants; most...
Tic disorders (TD) often present with associated neuropsychiatric comorbidities. This study aims to examine the clinical manifestations of TD in pediatric patients and explore spectrum features comorbidities among Chinese children diagnosed TD. A retrospective analysis was conducted on cases newly at our institution, using Mini International Neuropsychiatric Interview for Children Adolescents 5.0 screen Furthermore, a statistical undertaken. The enrolled 182 patients, comprising 140 males 42...
The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction cases worldwide, yet subset those infected are at risk for severe disease. We measured plasma acute respiratory syndrome 2 (SARS-CoV-2) RNA cohort 103 hospitalized with COVID-19 diverse clinical manifestations. SARS-CoV-2 RNAemia was detected 27 (26%) these children, lasted median 6 (interquartile range, 2-9) days, and associated higher rates oxygen administration, admission to the intensive care unit, longer...
Displaced lateral malleolus fractures are typically stabilised through open reduction and internal fixation. The biomechanically clinically efficacy of locking plates lag screws, particularly in Weber A B distal fibular remains a subject contention. This study examines two plate designs for fractures, evaluating their performance with without interfragmentary screws using finite element models.Utilising CT images healthy adult male volunteer, three-dimensional model was constructed....