A5046664219- Solid State Laser Technologies
- Advanced Fiber Laser Technologies
- Photorefractive and Nonlinear Optics
- Luminescence Properties of Advanced Materials
- RNA modifications and cancer
- Photonic Crystal and Fiber Optics
- Cancer-related molecular mechanisms research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Laser Design and Applications
- Cancer, Hypoxia, and Metabolism
- Radio Frequency Integrated Circuit Design
- Insect and Pesticide Research
- Cancer-related gene regulation
- Spectroscopy and Laser Applications
- Laser Material Processing Techniques
- Bee Products Chemical Analysis
- Photonic and Optical Devices
- Ocular and Laser Science Research
- Glass properties and applications
- Advanced Chemical Sensor Technologies
- Orbital Angular Momentum in Optics
- Laser-Matter Interactions and Applications
- Optical Coherence Tomography Applications
- Semiconductor Quantum Structures and Devices
Hebei Medical University
2025
China Pharmaceutical University
2024-2025
Jinan University
2015-2024
State Key Laboratory of Natural Medicine
2024
First Affiliated Hospital of Dalian Medical University
2024
Jiangsu University of Science and Technology
2024
Dalian Medical University
2024
Shandong University
2022-2023
Southern University of Science and Technology
2023
Huazhong University of Science and Technology
2023
Long noncoding RNAs (lncRNA) regulate a number of aspects cancer biology. Recent research has shown that lncRNAs can encode micropeptides mediate their functions in tumors. Here, we revealed the liver-specific putative lncRNA, AC115619, is expressed at low levels hepatocellular carcinoma (HCC) and encodes micropeptide, designated as AC115619-22aa. AC115619 played crucial role regulation tumor progression was prognostic indicator HCC. The encoded micropeptide AC115619-22aa inhibited HCC by...
We demonstrate the first ten-watt-level eye-safe intracavity crystalline Raman laser, to best of our knowledge. The efficient high-power laser is intracavity-pumped by an acousto-optically Q-switched 1314 nm two-crystal Nd:YLF laser. Benefiting from unique bi-axial properties KGW crystal, two sets dual-wavelength lasers operating at 1461, 1645 and 1490, 1721nm are achieved rotating crystal. Under launched pump power 84.9 W repetition rate 4 kHz, maximum first-Stokes output powers 7.9 1461...
We demonstrate an 806 nm laser diode end-pumped continuous-wave (CW) and actively Q-switched (AQS) orthogonally-polarized dual-wavelength Nd:YLF operating at 1314 1321 nm. Benefitting from the small difference of stimulated emission cross sections in crystal, power equalized emissions both wavelengths were achieved by simply titling output coupler. A maximum CW 9.2 W was obtained with incident pump 32.5 W, giving optical-to-optical conversion efficiency approximately 28% a slope 33%....
We demonstrate the first multi-segmented Nd:YLF laser, to best of our knowledge. The crystal was designed straightforwardly aim for minimum thermal stress without sacrificing overall laser efficiency, with influence pump beam waist position considered in particular. Integrating enhanced thermo-mechanical resistance and alleviated heat load low quantum defect pumping, this end-pumped 1314 nm system delivered a maximum continuous-wave output power up 35.5 W under 105 W, corresponding an...
A highly powerful nanosecond pulsed deep-red laser was demonstrated by intracavity second-harmonic generation of an actively Q-switched Nd:YLF dual-crystal-based KGW Raman in a critically phase-matched lithium triborate (LBO) crystal. The first-Stokes fields at 1461 and 1490 nm driven the 1314 fundamental were firstly produced accessing shifts 768 901 cm −1 crystal, respectively, thereafter converted to emission lines 731 745 finely tuning phase-matching angle LBO crystal carefully...
A wireless biotelemetry system operates in vivo, which requires low power consumption for long-lasting operation, high output long transferable distance, and throughput incorporating many recording electrodes transmitting raw brain signals. An implantable 2.4-GHz on-off keying (OOK) transmitter with energy efficiency systems has been designed a 0.18-μm CMOS process. To balance power, complementary voltage-controlled oscillator the proposed is employed. Power of reduced by switching on off to...
We construct a microscopic hyperspectral imaging system to distinguish between normal and cancerous gastric cells. study common transmission-spectra features that only emerge when the samples are dyed with hematoxylin eosin (H&E) stain. Subsequently, we classify obtained visible-range transmission spectra of into three zones. Distinct observed in spectral responses cell nuclei each zone, which depend on pH level nucleus. Cancerous cells precisely identified according these features. The...
We report a high average power actively Q-switched (AQS) orthogonal polarization dual-wavelength Nd:YLF laser at 1047 and 1053 nm. The gain-to-loss balance of dual wavelengths was realized via an uncoated quartz etalon. A maximum continuous wave (CW) output 14.2 W obtained under the incident pump 41.7 W, corresponding to optical-to-optical conversion efficiency 34.1% slope 38.3%. Active Q-switching accomplished by inserting acousto-optic modulator in cavity. Under 40 this setup delivered 10...
The development of an objective and rapid method that can be used for the early diagnosis gastric cancer has important clinical application value. In this study, fluorescence hyperspectral imaging technique was to acquire spectral images. Deep learning combined with spectral-spatial classification methods based on 120 fresh tissues samples had a confirmed by histopathological examinations automatically identify extract "spectral + spatial" features construct model cancer. results showed...
A compact dual-wavelength passively Q-switched green laser by intra-cavity frequency doubling of a Yb:YAG/Cr4+:YAG/YAG composite crystal was demonstrated for the first time to our best knowledge. The maximum output power 1.0 W obtained under pump 9.7 W, and corresponding slope efficiency is 15.2%. shortest pulse width, largest energy, highest peak were achieved be 5.54 ns, 246.1μJ, 40.76 KW, respectively. Dual-wavelength oscillation simultaneously at 515 nm 524.5 has been achieved. This can...
We demonstrate the first nanosecond pulsed single longitudinal mode (SLM) intracavity-pumped diamond Raman laser, to best of our knowledge. The eye-safe coherent source at 1634 nm, which was converted from actively Q-switched 1342 nm Nd:YVO4 yielded 4.35 W multimode average output power with a pulse duration 6 ns and peak 29 kW. By exploiting spatial hole burning free gain mechanism in media, stable SLM operation observed low (0.46 W) for free-running case. Furthermore, by incorporating an...
Low expression levels of breast cancer metastasis suppressor 1 like (BRMS1L) have been associated with the growth cells. However, mechanisms underlying role BRMS1L as an antitumour transcription factor in progression NSCLC not explored. Herein, we reveal that plays a key tumour inhibiting proliferation and metastasis. Mechanistically, overexpression results downregulation glutathione peroxidase 2 (GPX2) consequently causes abnormal metabolism increased reactive oxygen species (ROS) cells,...
We report on a high-power and narrow-linewidth nanosecond pulsed intracavity crystalline Raman laser at 1.7 µm. Driven by an acousto-optically Q-switched 1314 nm two-crystal Nd:YLF laser, the highly efficient cascaded YVO
Imbalanced production and clearance of amyloid-β (Aβ) is a hallmark pathological feature Alzheimer’s disease (AD). While several monoclonal antibodies targeting Aβ have shown reductions in amyloid burden, their impact on cognitive function remains controversial, with the added risk inflammatory side effects. Dysregulated stimulator interferon genes (STING) signaling implicated neurodegenerative disorders, yet biological interaction between this pathway Aβ, as well combined influence AD...
This study aimed to explore the application of surface-enhanced Raman scattering (SERS) in rapid diagnosis gastric cancer. The SERS spectra 68 serum samples from cancer patients and healthy volunteers were acquired. characteristic ratio method (CRM) principal component analysis (PCA) used differentiate normal serum. Compared with volunteers, intensity was relatively high at 722[Formula: see text]cm[Formula: text], while it low 588, 644, 861, 1008, 1235, 1397, 1445 1586[Formula: text]. These...
This study investigated the feasibility of using fluorescence hyperspectral imaging technology to diagnose early‐stage gastric cancer. Fluorescence spectral images 76 patients who were pathologically diagnosed as non‐atrophic gastritis, premalignant lesions and cancer collected. spectra at 100‐pixel points randomly extracted after binarization. Diagnostic models constructed through partial‐least‐square discriminant analysis (PLS‐DA) support vector machine (SVM) algorithms. The prediction...
A single-longitudinal-mode crystalline Raman laser in the 1.7 µm wave band was reported for first time, to best of our knowledge. The <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"> <mml:mrow class="MJX-TeXAtom-ORD"> <mml:msub> <mml:mi mathvariant="normal">Y</mml:mi> mathvariant="normal">V</mml:mi> mathvariant="normal">O</mml:mi> </mml:mrow> <mml:mn>4</mml:mn> </mml:msub> </mml:math> laser, which intracavity-pumped by an actively <mml:mi>Q</mml:mi> -switched 1314...