Hancong Xu

ORCID: 0009-0003-5485-8360
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About
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Research Areas
  • Medical Imaging Techniques and Applications
  • Advanced X-ray and CT Imaging
  • Advanced MRI Techniques and Applications
  • Radiation Detection and Scintillator Technologies
  • Biofuel production and bioconversion
  • Food composition and properties
  • Digital Radiography and Breast Imaging
  • Advanced Radiotherapy Techniques
  • Radiomics and Machine Learning in Medical Imaging
  • Cell Image Analysis Techniques
  • Advanced Combustion Engine Technologies
  • Biosensors and Analytical Detection
  • Radiation Dose and Imaging
  • Microbial Metabolites in Food Biotechnology
  • Electromagnetic Launch and Propulsion Technology
  • Vibrio bacteria research studies
  • Digital Holography and Microscopy
  • Cavitation Phenomena in Pumps
  • Hydraulic and Pneumatic Systems
  • 3D Surveying and Cultural Heritage
  • Virus-based gene therapy research
  • Image Processing Techniques and Applications
  • Advanced biosensing and bioanalysis techniques
  • Digital Image Processing Techniques
  • RNA Interference and Gene Delivery

Nanjing Agricultural University
2024

Dalian Maritime University
2022-2023

United Imaging Healthcare (China)
2021-2022

Hebei Agricultural University
2021

Forschungszentrum Jülich
2018-2019

RWTH Aachen University
2019

State Key Laboratory of Digital Medical Engineering
2014

Southeast University
2014

Abstract In cereal grains, starch is synthesized by the concerted actions of multiple enzymes on surface granules within amyloplast. However, little known about how starch-synthesizing access granules, especially for amylopectin biosynthesis. Here, we show that rice (Oryza sativa) floury endosperm9 (flo9) mutant defective in biosynthesis, leading to grains exhibiting a endosperm with hollow core. Molecular cloning revealed FLO9 encodes plant-specific protein homologous Arabidopsis...

10.1093/plcell/koae006 article EN The Plant Cell 2024-01-23

A synthesized PEI-based gene delivery system, wherein PEI was crosslinked with sulfosuccinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (Sulfo-SMCC) conjugating trans-activating transcriptional activator (TAT), yielding PEI-SMCC-TAT (PST), a novel non-viral vector for apoptosis-related PUMA (p53 up regulated modulator of apoptosis), designed and evaluated. Sulfo-SMCC is commonly used heterobifunctional crosslinker soluble in water, making the crosslinking easier without organic...

10.1166/jbn.2015.2151 article EN Journal of Biomedical Nanotechnology 2015-07-14

Starch is synthesized as insoluble, semicrystalline particles within plant chloroplast and amyloplast, which are referred to starch grains (SGs). The size morphology of SGs in the cereal endosperm diverse species-specific, representing a key determinant suitability for industrial applications. However, molecular mechanisms modulating SG remain elusive. Here, we functionally characterized rice (Oryza sativa) mutant substandard grain7 (ssg7), exhibits enlarged defective development. SSG7...

10.1111/pbi.14444 article EN cc-by-nc-nd Plant Biotechnology Journal 2024-08-24

Accurate scatter correction is essential for qualitative and quantitative PET imaging. Until now, based on Monte Carlo simulation (MCS) has been recognized as the most accurate method of PET. However, major disadvantage MCS its long computational time, which makes it unfeasible clinical usage. Meanwhile, single (SSS) widely used correction. Nevertheless, SSS limited robustness dynamic measurements measurement large objects. In this work, a newly developed implementation using graphics...

10.1109/tmi.2019.2921872 article EN IEEE Transactions on Medical Imaging 2019-06-11

Abstract As a marine food‐borne pathogen, Vibrio parahaemolyticus ( V. ) can cause human gastrointestinal disorders and pose serious threat to food safety public health worldwide. Using portable scanner, herein, real‐time fluorescence saltatory rolling circle amplification (RF‐SRCA) has been established for the rapid detection of in seafood targeting toxR gene. The RF‐SRCA results could be effectively determined within 20–60 min via curve. Significant specificity was exhibited against 12 V ....

10.1111/ijfs.15285 article EN International Journal of Food Science & Technology 2021-07-29

Positron emission tomography (PET) images usually suffer from limited resolution and statistical uncertainties. However, a technique known as modeling (RM) can be used to improve image quality by accurately the system's detection process within iterative reconstruction. In this study, we present an accurate RM method in projection space based on simulated multi-block detector response function (DRF) evaluate it Siemens hybrid MR-BrainPET system. The DRF is obtained using GATE simulations...

10.1088/1361-6560/ab266b article EN cc-by Physics in Medicine and Biology 2019-06-03

Autofocus is an important technique for high-speed image acquisition in the second-generation DNA sequencing system, and this paper studies passive focus algorithm which consists of two parts: measurement (FM) search (FS). Based on properties chips' images, we choose normalized variance as FM develop a new robust FS named adaptive prediction approximation combined (APACS). APACS utilizes golden section (GSS) to approximate position engages curve-fitting (CFS) predict simultaneously every...

10.1364/ao.53.004509 article EN Applied Optics 2014-07-07

Benefited from the hardware upgrade, time-of-flight (TOF) resolution of PET/CT scanners has been significantly improved, which can accurately locate annihilation events and obtain high quality histo-image. On other hand, scatter correction methods usually rely on iterative calculations to accurate emission distribution, is time-consuming. In this work, a deep learning assisted algorithm was proposed. This generates distribution TOF histo-image with neural network, directly estimates through...

10.1109/nss/mic44845.2022.10399062 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2022-11-05

In order to simplify the Point-Spread-Function (PSF) reconstruction framework, resolution modelling can be decoupled from iterative process by an additional data resampling step previous reconstruction. We call proposed algorithm RESampling between Projection spACEs (RESPACE). this abstract, RESPACE is applied resample simulated projection 2D Generic Cylinder Model (GCM) structure, which will used for afterwards. Theoretically, merges pre-calculated detection probability information and...

10.1109/nssmic.2018.8824431 article EN 2018-11-01

Position emission tomography (PET) images usually suffer from low spatial resolution and signal-to-noise (SNR) ratio. The degradation of image in PET is caused by detection process, e.g. inter-crystal scattering, crystal penetration. An Accurate Detector Response Functions (DRF) allows to model these phenomena increase the as well SNR iterative reconstruction. However, fully 3D DRF for pixelated arrays (block) which also considers inter-block penetration scattering between different blocks...

10.1109/nssmic.2018.8824424 article EN 2018-11-01

A method to monitor and correct crystal-level Time-of-Flight (TOF) offset error of Positron Emission Tomography system based on NEMA NEC phantom data is studied, which improves the accuracy TOF resolution measurement reduces dependence time correction experiment. The calculates each crystal with difference all true coincidence events, are decided by removing scatter random events following test in NU2-2018. due physical position line source corrected. centroid statistical distribution...

10.1109/nss/mic44845.2022.10399044 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2022-11-05

In PET/CT, segmentation of anatomical structures is often performed on the CT. However, this practice assumes a PET-matched CT image available, which can be violated due to patient movement between and PET acquisitions. This limitation may addressed by segmenting organs based itself, e.g., non-attenuation corrected (NAC) PET. With improvement in TOF resolution scanner, uMI Panorama with 196-ps TOF, structure histoimage, generated back-projecting bin center each event, used for domain...

10.1109/nss/mic44845.2022.10399026 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2022-11-05

CT-based attenuation image (μmap) is used in a PET/CT study. However, the motion introduced mismatch between PET and CT, artifacts CT itself can result artifacts. Synthesizing μmap using AI from data draws increasing attention. Compared to MLAA or non-AC images for neural network input, histo-images obtained excellent systems, e.g., uMI Panorama (sub 200 ps TOF), provides sufficient structure information with <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...

10.1109/nss/mic44845.2022.10399008 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2022-11-05

Positron emission tomography (PET) applies the time information in image reconstruction to enhance quality. However, conventional time-of-flight (TOF) modeling with a single Gaussian function cannot meet requirements of various detector designs. For instance, if detectors involve events Cherenkov radiation or Compton scatter recovery (CSR), multiple is more suitable rather than function. In this abstract, double two different sets configurations applied conduct blurring on simulated...

10.1109/nss/mic44867.2021.9875748 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2021-10-16

Dynamic whole-body PET parametric imaging has been widely investigated and demonstrated clinically feasibility. In the step-and-shoot dynamic protocol, an average time point is often assigned to overlapped slices between adjacent beds. This sum-frame strategy based on assumption that concentration not varying significantly, which may be guaranteed for all voxels covered in space. However, when separate points are assigned, unbalanced data noise due sensitivity drop edge of each bed causes...

10.1109/nss/mic44867.2021.9875837 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2021-10-16

A resolution modelling method based on the Monte Carlo simulation (MCS) is proposed to achieve optimal image quality of uMI Panorama PET/CT System. For sufficient counting statistics, a fast MCS algorithm powered by GPU has been developed. The simulated transverse system response stored as lookup table (LUT) coincident aperture function (CAF) taking advantage symmetric detector structure. Parametric fitting asymmetric Gaussian functions used describe axial CAF related distance between...

10.1109/nss/mic44867.2021.9875754 article EN 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) 2021-10-16
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