A5088507461- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- GABA and Rice Research
- ATP Synthase and ATPases Research
- Birth, Development, and Health
- Insect Utilization and Effects
- Bioactive Compounds and Antitumor Agents
- Coenzyme Q10 studies and effects
- Sphingolipid Metabolism and Signaling
- Biochemical Acid Research Studies
Cornell University
2022-2025
University of Massachusetts Chan Medical School
2025
Morningside College
2025
Highlights•RQ is present in mitochondria isolated from certain mouse and human tissues•RQ carries electrons to fumarate as the electron acceptor, independently of O2 levels•The ETC can be reprogrammed RQ/fumarate pathway using genetic pharmacologic tools•Reprogramming mitigates hypoxia-induced damage vitro vivoSummaryUbiquinone (UQ), only known carrier mammalian transport chain (ETC), preferentially delivers terminal acceptor oxygen (O2). In hypoxia, ubiquinol (UQH2) diverts these onto...
Abstract Recent studies of animal metabolism have revealed large numbers novel metabolites that are involved in all aspects organismal biology, but it is unclear to what extent metabolomes differ between sexes. Here, using untargeted comparative metabolomics for the analysis wildtype animals and sex determination mutants, we show C. elegans hermaphrodites males exhibit pervasive metabolomic differences. Several hundred small molecules produced exclusively or much larger amounts one sex,...
Physiological dysfunction confers negative valence to coincidental sensory cues induce the formation of aversive associative memory. How peripheral tissue stress engages neuromodulatory mechanisms form memory is poorly understood. Here, we show that in nematode C. elegans, mitochondrial disruption induces through peroxisomal β-oxidation genes non-neural tissues, including pmp-4/very-long-chain fatty acid transporter, dhs-28/3-hydroxylacyl-CoA dehydrogenase, and daf-22/3-ketoacyl-CoA...
Abstract Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids precursors diverse signaling molecules. Nutritional conditions associated microbiota regulate desaturase expression, but the underlying mechanisms have remained unclear. Here, we show that endogenous microbiota-dependent small molecule signals promote via nuclear receptor NHR-49/PPARα in C. elegans . Untargeted metabolomics a β-oxidation mutant, acdh-11 , which expression...
From bacterial quorum sensing to human language, communication is essential for social interactions. Nematodes produce and sense pheromones communicate among individuals respond environmental changes. These signals are encoded by different types mixtures of ascarosides, whose modular structures further enhance the diversity this nematode pheromone language. Interspecific intraspecific differences in ascaroside language have been described previously, but genetic basis molecular mechanisms...
ABSTRACT Fatty acid desaturation is central to metazoan lipid metabolism and provides building blocks of membrane lipids precursors diverse signaling molecules. Nutritional conditions associated microbiota regulate desaturase expression 1–4 , but the underlying mechanisms have remained unclear. Here, we show that endogenous microbiota-dependent small molecule signals promote via nuclear receptor NHR-49/PPARα in C. elegans . Untargeted metabolomics a β-oxidation mutant, acdh-11 which...