A5016917789- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Pain Management
- Cancer, Stress, Anesthesia, and Immune Response
- Pain Mechanisms and Treatments
- Respiratory Support and Mechanisms
- Thermoregulation and physiological responses
- Neuroinflammation and Neurodegeneration Mechanisms
- Thermal Regulation in Medicine
- Nausea and vomiting management
- Cardiac Arrest and Resuscitation
- Epilepsy research and treatment
- Neuropeptides and Animal Physiology
- Food Allergy and Anaphylaxis Research
- Spine and Intervertebral Disc Pathology
- Healthcare and Venom Research
- Family and Patient Care in Intensive Care Units
- Diet and metabolism studies
- Proteoglycans and glycosaminoglycans research
- Ultrasound in Clinical Applications
- Immune cells in cancer
- Signaling Pathways in Disease
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
Southern Medical University
2014-2025
Nanfang Hospital
2012-2025
Key Laboratory of Guangdong Province
2025
Inadvertent intraoperative hypothermia (core temperature <36°C) is a frequently preventable complication with several adverse consequences. Our study aimed to determine the overall incidence of inadvertent and its risk factors associated clinical outcomes in this national survey China.We conducted cross-sectional 30 days postoperative follow-up from November 2014 through August 2015. A total 3132 eligible patients underwent general anesthesia were randomly selected 28 hospitals nationwide...
The underlying pathophysiological mechanisms of cerebral ischemia reperfusion injury (CIRI) is intricate, and current studies suggest that neuron, astrocyte, microglia, endothelial cell, pericyte all have different phenotypic changes specific cell types after ischemic stroke. And microglia account for the largest proportion CIRI. Previous transcriptomic stroke typically focused on 24 hours CIRI, obscuring dynamics cellular subclusters throughout disease process. Therefore, traditional...
Abstract Accumulating evidence supports the notion that microglia play versatile roles in different chronic pain conditions. However, therapeutic strategies of by targeting remain largely overlooked. This study seeks to develop a miRNA-loaded nano-delivery system microglia, which could provide decent and long-lasting analgesia for pain. Surface aminated mesoporous silica nanoparticles were adopted load miR-26a-5p, potent analgesic miRNA, electrostatic adsorption, can avoid miR-26a-5p is...
Inadvertent intraoperative hypothermia (core temperature <36 °C) is a frequent but preventable complication of general anesthesia. Accurate risk assessment individual patients may help physicians identify at for and apply preventive approaches, which include active warming. This study aimed to develop validate risk-prediction model hypothermia. Two independent observational studies in China, the Beijing Regional Survey China National Survey, were conducted 2013 2014, respectively, determine...
Mitochondrial dysfunction, which can be regulated by mitophagy, plays a central role in diabetic neuropathic pain (DNP). Mitophagy that was involved nerve damage-induced has been reported. Hyperglycemia and cellular hypoxic were the two main characters of diabetes. Hypoxia-inducible factor 1
Aims Melatonin may improve the prognosis of severe COVID‐19 patients. However, association between its analogue ramelteon and survival outcomes patients remains unclear. This retrospective study was conducted to investigate this knowledge gap. Methods The data admitted ICU were extracted from Medical Information Mart for Intensive Care IV 3.0 database. Patients categorized into group non‐ramelteon based on corresponding treatment. primary outcome 30‐day mortality. Subsequently, propensity...
Epigenetic changes in the spinal cord play a key role initiation and maintenance of nerve injury-induced neuropathic pain. N6-methyladenosine (m6A) is one most abundant internal RNA modifications plays an essential function gene regulation many diseases. However, global m6A modification status mRNA at different stages after pain unknown. In this study, we established model mice by preserving complete sural only damaging common peroneal nerve. High-throughput methylated immunoprecipitation...
Hyperthermia not only directly induces cell injury of body tissues, but also causes the to release large amounts inflammatory mediators and cells with extensive biological activities induce a systemic response immune dysfunction. Thus, hyperthermia syndrome, aggravating injuries various organs. This study aimed observe effects ulinastatin (UTI) administered at different time points on cellular morphologies lung tissues rats hyperthermia. A total 40 male Sprague Dawley were randomly divided...
Background: Painless gastroscopy is preferred by both patients and physicians, as it minimizes discomfort during the procedure. Alfentanil, a short-acting opioid analgesic, possesses pharmacological properties that make suitable for inducing analgesia gastroscopy. However, research on optimal dosage of alfentanil when used in combination with propofol
Previous studies have suggested a potential link between delirium and mitochondrial function. Consequently, this Mendelian randomisation (MR) study aimed to further investigate their causal relationship.
Abstract Background Studies focusing on the relationship between gastric volume and facemask oxygenation without ventilation during apnea in anesthesia induction are scarce. This study compared change using adults undergoing laparoscopic surgery. Methods In this prospective, randomized, double-blinded trial, 70 surgery under general were divided into two groups to receive with for 60 seconds after loss of consciousness. Before endotracheal intubation, antral cross-sectional area was measured...
Objective To investigate the median effective plasma concentration (Cp50) of propofol blunting cardiovascular responses to tracheal intubation with sufentanil at different targeted concentrations on anesthesia induction in elderly patients.Methods Ninty-four patients (60 years-79 years) an American Society ASA physical status Ⅰ -Ⅲ,undergoing scheduled surgery under general were randomly allocated into one four groups:group A,B,C and D.The group A B years-69 ones C D(70 received a target...