A5102715042- Glioma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Signaling Pathways in Disease
- Neurogenetic and Muscular Disorders Research
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Ferroptosis and cancer prognosis
- Genetic Syndromes and Imprinting
- Brain Metastases and Treatment
- Biochemical and Molecular Research
- Neurofibromatosis and Schwannoma Cases
- Adenosine and Purinergic Signaling
- Sarcoma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
Hospital for Sick Children
2023-2025
University of Toronto
2024-2025
SickKids Foundation
2023-2024
St. Michael's Hospital
2023
There is considerable evidence for a role metabolic dysregulation, including disordered purine nucleotide metabolism, in the pathogenesis of Alzheimer's disease (AD). Purine synthesis brain regulated with high fidelity to co-ordinate supply demand. The assembly some biosynthetic enzymes into linear filamentous aggregates called "cytoophidia" (Gk. Cellular "snakes") represents one post-translational mechanism regulate enzyme activity. Cytoophidia comprised inosine monophosphate dehydrogenase...
Introduction: Glioblastoma or GBM is an aggressive brain cancer with a 5 year survival rate below 10 percent. Glioma stem cells GSCs drive formation, growth, and resistance. Previously, analysis of 17,601 phase contrast images from 15 patients revealed that neurodevelopmental form smaller, uniform clusters, while mesenchymal injury-response exhibit complex, irregular growth patterns. This new study examines the spatial distribution local cellular niche along gradient in primary GBM. We...
Abstract Background: Glioblastoma (GBM) is the most common malignant brain tumor in adults. Despite extensive research, there haven’t been remarkable gains resolving seeds of glioblastoma recurrence, and outcomes for many patients suffering from this devastating disease remain poor. Complete resection GBM not possible. Residual therapy-resistant cells drive recurrence infiltrative expansion. Our knowledge on heterogeneity mostly restricted to surgically resectable core, while functional...
Glioblastoma accounts for nearly half of all primary malignant brain tumors in adults, and despite an aggressive standard care, including excisional surgery adjuvant chemoradiation, recurrence remains universal, with overall median survival 14.6 months. Recent work has revealed the importance passenger mutations as critical mediators metabolic adaptation cancer progression. In our previous work, we identified a role epigenetic modifier ID-1 temozolomide resistance glioblastoma. Here, show...
Abstract Breast cancer is the most common type of in women. It also 2nd cause brain metastases (BrM), with 30-50% breast patients developing BrM over course their disease. Despite aggressive therapy and novel systemic treatment options, prognosis for these remains poor. The objectives our work were to identify underlying genomic transcriptomic signatures that characterise early establishment cancer, brain-intrinsic molecular mechanisms critical development. We performed profiling on fresh...
Abstract Complete tumour resection in glioblastoma patients is not possible. Residual therapy-resistant edge-derived cells drive recurrence and infiltrative expansion glioblastoma. Features that are specific to malignant may serve as predictive biomarkers allow individual tailoring of the treatment plan slow down invasion prevent GBM following standard therapy. Intratumoural spatial heterogeneity facilitates therapeutic resistance Our knowledge on mostly restricted surgically resectable...
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