A5081929848- Advanced Biosensing Techniques and Applications
- Analytical Chemistry and Sensors
- Biosensors and Analytical Detection
- Per- and polyfluoroalkyl substances research
- Advanced Fiber Optic Sensors
- Photonic and Optical Devices
- Plasmonic and Surface Plasmon Research
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Luminescence and Fluorescent Materials
- COVID-19 diagnosis using AI
- Thermal Radiation and Cooling Technologies
- Advanced biosensing and bioanalysis techniques
- Stress Responses and Cortisol
- Olfactory and Sensory Function Studies
University of Campania "Luigi Vanvitelli"
2023-2025
In this work, a novel optical fiber sensor system for ultra-low perfluorooctanoic acid (PFOA) detection in aqueous solutions is proposed. It based on the connection, series, of two different plastic (POF) platforms: first chemical chip realized by using D-shaped POF with microholes filled specific molecularly imprinted polymer (MIP); second typical surface plasmon resonance (SPR) POF. particular, MIP-based was used to launch light inside SPR–POF change SPR phenomenon exploiting PFOA–MIP...
Cortisol is a clinically validated stress biomarker that takes part in many physiological and psychological functions related to the body's response factors. In particular, it has emerged as pivotal tool for understanding levels overall well-being. Usually, clinics, cortisol are monitored blood or urine, but significant changes also registered sweat saliva. this work, surface plasmon resonance probe based on D-shaped plastic optical fiber was functionalized with glucocorticoid receptor...
A plastic optical fiber (POF)-based device for biosensing strategies has been developed to monitor several protein–protein interactions at ultra-low concentrations without functionalization processes, exploiting plasmonic phenomena. In this work, novel tests were applied different kinds of analyte–receptor interactions, such as interleukins, where the bioreceptor’s (protein antibody) molecular weight is roughly ten times that analyte interleukin), while intracellular bioreceptors and small...
Interleukins are involved in several diseases and cancers, their detection monitoring of great interest. Their low abundance short half-lives suggest the need to develop rapid, specific, highly sensitive platforms, easily integrable point-of-care (POC) systems. Among other interleukins, interleukin IL-17A is associated with inflammations, neurodegenerative diseases, no biosensors have been previously reported for its detection. In this work, IL-17A, a nanoplasmonic sensor based on natural...
Molecularly imprinted polymers (MIPs) can be combined with optical fibers (OFs) to create various sensor configurations, yielding low-cost and highly sensitive extrinsic intrinsic sensors. In this work, an MIP-based fiber is obtained by two silica OFs connected via waveguide using MIP as a core of micrometer size (micro OF-MIP-OF sensor). The proposed sensing approach used only receptors implements intensity-based configuration. MIPs present several advantages over bio-receptors exploited...
Optical–chemical sensors based on optical fibers can be made in reflection or transmission schemes. In the scheme, sensing area is typically present at end of fiber, and light source detector are placed same side fiber. This approach exploited to achieve chemical probes useful several application fields where remote required. this work, obtain an extrinsic fiber sensor a two used monitor chemically sensitive region achieved by C-shaped waveguide with molecularly imprinted polymer (MIP) as...
In this work, a novel optical–chemical sensor for the detection of per- and polyfluorinated substances (PFASs) in real scenario is presented. The proposed sensing approach exploits multimode characteristics plastic optical fibers (POFs) to achieve unconventional sensors via surface plasmon resonance (SPR) phenomena. realized by coupling an SPR-POF platform with chemical chip based on different polymeric nanolayers over core D-shaped POF, one made up adhesive molecularly imprinted polymer...
In this work, Fe2O3 was investigated as a doping agent for poly(methyl methacrylate) (PMMA) in order to enhance the plasmonic effect sensors based on D-shaped plastic optical fibers (POFs). The procedure consists of immerging premanufactured POF sensor chip an iron (III) solution, avoiding repolymerization and its related disadvantages. After treatment, sputtering process used deposit gold nanofilm doped PMMA obtain surface plasmon resonance (SPR). More specifically, increases refractive...
A successful immunosensor is characterized by a proper antibody immobilization and orientation in order to enhance the antigen recognition. In this work, thorough characterization of functionalized gold surface performed set up best conditions implement an optical platform for detection Brucella sp. Two different strategies are evaluated, based on random oriented one: direct carboxylic mixed polyethylene (PEG) self-assembled monolayer (SAM) or only PEG SAM interface compared layer protein G...