A5000311694- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- COVID-19 diagnosis using AI
- Phytochemical compounds biological activities
- Multicomponent Synthesis of Heterocycles
- Infection Control and Ventilation
- Rabies epidemiology and control
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Plant Parasitism and Resistance
- Syphilis Diagnosis and Treatment
- Herbal Medicine Research Studies
- Microbial Community Ecology and Physiology
- Vaccine Coverage and Hesitancy
- Synthesis and biological activity
- Microbial Fuel Cells and Bioremediation
- Plant and animal studies
- Insect-Plant Interactions and Control
- COVID-19 Clinical Research Studies
- Neuroscience and Neural Engineering
- Genomics and Rare Diseases
- Moringa oleifera research and applications
- Pharmacological Effects of Natural Compounds
Istituto Superiore di Sanità
2021-2024
Natural products are a rich source of bioactive molecules that have potential pharmacotherapeutic applications. In this study, we focused on Artemisia annua (A. annua) and its enriched extracts which were biologically evaluated in vitro as virucidal, antiviral, antioxidant agents, with application against the COVID-19 infection. The crude extract showed antiviral effects concentrations did not affect cell viability. Scopoletin, arteannuin B artemisinic acid (single fractions isolated from A....
ObjectivesTo evaluate whether the increase of temperature can influence environmental endurance severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).MethodsVirus was inoculated on a plastic surface and harvested at predefined time-points in parallel 20°C–25°C (room temperature; RT) 28°C (June JT). Samples were tested by TCID50 titres Vero cells.ResultsOur results confirm that fomite transmission emerging SARS-CoV-2 is possible: virus reserved its ability to infect cells for up 84...
Since late 2023, the Metropolitan City of Milan and surrounding areas (northern Italy) have been experiencing a resurgence measles, with most cases detected starting from January 2024. During this brief period, we observed measles in travellers endemic areas, participants international events, vaccinees healthcare workers. Indigenous also identified. Even though not yet identified large disruptive outbreaks, strengthening surveillance vaccination activities is pivotal to help limit impact spread.
The COVID-19 pandemic represents an unprecedented global emergency. Despite all efforts, remains a threat to public health, due the complexity of mass vaccination programs, lack effective drugs, and emergence new variants. A link has recently been found between risk developing severe infection high level oxidative stress. In this context, we have focused our attention on natural compounds with aim finding molecules capable acting through dual virucidal-antioxidant mechanism. particular,...
Subacute sclerosing panencephalitis (SSPE) is a late complication of measles virus infection that occurs in previously healthy children. This disease has no specific cure and associated with high degree disability mortality. In recent years, there been an increase its incidence relation to reduction vaccination adherence, accentuated by the COVID-19 pandemic. this article, we take stock current evidence on SSPE report our personal clinical experience. We emphasise that, date, only effective...
An outbreak of measles virus genotype B3 is ongoing in Milan and surrounding areas since February 2025, with 27 cases identified 32 laboratory-confirmed cases. Most were locally acquired young adults. Phylogenetic analysis indicated the presence a unique lineage closely related to strains circulating Morocco. The lack epidemiological links between several affected individuals suggests case numbers are being underestimated. continuous transmission raises concerns about potential...
The emergence of the new pathogen SARS-CoV-2 determined a rapid need for monoclonal antibodies (mAbs) to detect virus in biological fluids as tool identify infected individuals be treated or quarantined. majority commercially available antigenic tests rely on detection N antigen biologic fluid using anti-N antibodies, and their capacity specifically subjects by is questionable due several structural analogies among proteins different coronaviruses. In order produce specific BALB/c mice were...
The current SARS-CoV-2 pandemic and the likelihood that new coronavirus strains will emerge in immediate future point out urgent need to identify pan-coronavirus inhibitors. Strigolactones (SLs) are a class of plant hormones with multifaceted activities whose roles plant-related fields have been extensively explored. Recently, we proved SLs also exert antiviral activity toward herpesviruses, such as human cytomegalovirus (HCMV). Here show synthetic TH-EGO EDOT-EGO impair β-coronavirus...
COVID-19 continues to claim victims in the world, especially among elderly subjects and people suffering from chronic-degenerative pathologies, like cardiovascular diseases. Several vaccines drugs have been developed mitigate infection spread its deleterious consequences. However, emergence of new variants requires identification solutions deal with challenging mutations. In this context, investigation phytocomplexes related compounds used folk medicine culinary purposes may lead unfold...
COronaVIrus Disease 2019 (COVID-19) is a newly emerging infectious disease that spread across the world, caused by novel coronavirus Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2).Despite advancements in science led to creation of vaccine, there still an urgent need for new antiviral drugs effective against SARS-CoV-2.This study aimed investigate effect Paulownia tomentosa Steud extract SARS-CoV-2 and evaluate its antioxidant properties, including respiratory smooth muscle...
Biofilm at water-oil interface of hypoxic water columns microcosms, prepared from a lacustrine sample, that used diesel as carbon source was found to show electrogenic properties. These microcosms named, Liquid Microbial Fuel Cells (L-MFCs) were electrically characterized using custom electronic analyzer; accurate determination voltage (V), power density (W/m 2), and current (A/m2) for both charge discharge phases carried out. The instrument made it possible carry out cell characterizations...