A5041703885- Anesthesia and Pain Management
- Anesthesia and Sedative Agents
- Nausea and vomiting management
- Veterinary Pharmacology and Anesthesia
- Sepsis Diagnosis and Treatment
- Cardiac pacing and defibrillation studies
- Anesthesia and Neurotoxicity Research
- Spine and Intervertebral Disc Pathology
- Shoulder Injury and Treatment
- Pain Management and Treatment
- Respiratory Support and Mechanisms
- Inflammatory Biomarkers in Disease Prognosis
- Pain Management and Opioid Use
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2021-2025
Spitalul Clinic Judetean de Urgenta Târgu Mureş
2023-2024
Knowledge of drug pharmacokinetics and tissue distribution is precious for ensuring patient safety optimizing treatments. The varied use local anesthetics, as well the fact that anesthetics can sometimes have low therapeutic indices numerous adverse reactions, makes any novel information valuable. present manuscript describes a pharmacokinetic study ropivacaine carried out after plane block anesthesia on an animal model, using high sensitivity, accurate, precise LC-MS/MS bioanalysis. Both...
Introduction: Ropivacaine is a popular local anesthetic used for regional anesthesia or pain management. Although designed as an enantiomerically pure drug, aspect that reduces the adverse effects, its toxicological effects are still risk. As such, biomonitoring to assure appropriate dosage and bioavailability essential avoid complications during post-surgery. Methods: The study focused on developing sensitive, selective, accurate liquid chromatography-mass spectrometry (LCMS/MS) method...
Abstract Introduction Acute respiratory distress syndrome (ARDS) represents a major cause of mortality in the intensive care unit (ICU). The inflammatory response is escalated by cytokines and chemokines released neutrophils, therefore search for quantifying impact this pathophysiological mechanism imperative. Neutrophil/lymphocyte ratio (NLR) platelet/lymphocyte (PLR) are indicators systemic inflammation, widely accessible, inexpensive, uncomplicated parameters. Methods We conducted...
Ropivacaine, a widely used regional anesthetic also for pain management, has been increasingly in recent years due to its increased efficacy and improved safety compared similar anesthetics. Biomonitoring of ropivacaine metabolites during after anesthesia is an essential process ensuring therapeutic safe usage patients. The most useful biomonitoring tool liquid chromatography coupled with mass spectrometry (LC-MS/MS), which offers selectivity, sensitivity, as well accuracy measurements....
Abstract Cardiac resynchronization therapy devices, implantable cardioverter defibrillators, and pacemakers are used to treat advanced systolic heart failure, ventricular tachyarrhythmias, bradyarrhythmia. Over the past ten years, there has been a notable rise in number of cardiac implanted electronic device implants because mounting evidence better survival quality life among specific patient populations. Appropriate analgesia sedation throughout implantation procedure is crucial for...