A5085680364- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Electrospun Nanofibers in Biomedical Applications
- Diabetic Foot Ulcer Assessment and Management
- Veterinary Pharmacology and Anesthesia
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Central Venous Catheters and Hemodialysis
- Periodontal Regeneration and Treatments
- S100 Proteins and Annexins
- Nerve injury and regeneration
- Tissue Engineering and Regenerative Medicine
- Mechanical Circulatory Support Devices
- Vascular anomalies and interventions
- Knee injuries and reconstruction techniques
- Amphibian and Reptile Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Infectious Aortic and Vascular Conditions
- Cardiac and Coronary Surgery Techniques
- Antimicrobial Resistance in Staphylococcus
- Signaling Pathways in Disease
- Clusterin in disease pathology
- Total Knee Arthroplasty Outcomes
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2015-2025
Biobase (Germany)
2024
Lucian Blaga University of Sibiu
2024
University of Oradea
2024
Carol Davila University of Medicine and Pharmacy
2024
Advanced Pharma
2024
Manchester Metropolitan University
2024
Ospedale SS. Annunziata
2024
Roosevelt University
2024
(1) Background: Arteriovenous fistula (AVF) is the preferred type of vascular access for dialysis in patients with end-stage kidney disease (ESKD). However, primary patency AVF at one year under 70% due to several risk factors and comorbidities. Leukocyte glucose index (LGI), a new biomarker based on blood leukocytes values, has been found be associated poor outcomes cardiovascular disease. The aim this study analyze impact LGI long-term following initiation. (2) Methods: We conducted...
Knowledge of drug pharmacokinetics and tissue distribution is precious for ensuring patient safety optimizing treatments. The varied use local anesthetics, as well the fact that anesthetics can sometimes have low therapeutic indices numerous adverse reactions, makes any novel information valuable. present manuscript describes a pharmacokinetic study ropivacaine carried out after plane block anesthesia on an animal model, using high sensitivity, accurate, precise LC-MS/MS bioanalysis. Both...
Critical ischemia of the lower limbs refers to last stages peripheral arterial disease. It is characterized by resting discomfort or trophic disorders such as ulceration, skin necrosis, gangrene in limbs. corresponds Leriche-Fontaine (LF) III-IV and Rutherford 4-6. The purpose this study was observe patency postoperative complications patients who have had infra-inguinal surgical revascularization compare results based on kind graft utilized.
Right ventricular (RV) failure is a common complication in multiple congenital heart disease (CHD), significantly increasing morbidity and mortality. Despite its impact, no therapies specifically target the failing RV. The growing population of CHD patients underscores need to understand pathophysiology RV through preclinical research. This study aimed develop an ovine model induced by pressure volume overload. A total 14 juvenile sheep randomly underwent pulmonary artery banding (n = 6),...
Peripheral nerve injuries are a significant clinical challenge. The rat sciatic serves as an ideal model for studying regeneration. Extensive research has been conducted to unravel the intricate mechanisms involved in peripheral regeneration, aiming develop effective therapeutic strategies injury patients. Research including different types of materials that can be used guides like synthetic polymers have investigated their biocompatibility and molding properties. Among multiple stem cell...
Abstract Objective : The aim of this article is to determine the predictive value leukocyte-glycemic index in long-term evolution diabetic patients with peripheral arterial disease following endovascular treatment. Methods This retrospective observational study enrolled 127 diagnosed requiring Patients were categorized into two groups based on severity infrapopliteal atherosclerotic lesions identified during pre-operative Computer Tomography Angiography examination. Group 1 includes without...
Background: Peripheral nerve injuries (PNIs) represent a significant clinical problem, and standard approaches to repair have limitations. Recent breakthroughs in 3D printing stem cell technologies offer promising solution for regeneration. The main purpose of this study was examine the biomechanical characteristics muscle tissue distal defect murine model peripheral regeneration from physiological stress failure. Methods: In experimental study, we enrolled 18 Wistar rats which created 10 mm...
Introduction The neurovascular unit (NVU), comprising vascular and glial cells along with neurons, is vital for maintaining the blood-brain barrier (BBB) cerebral homeostasis. Dysfunction of NVU implicated in key neurodegenerative disorders such as Alzheimer's disease (AD). Monomeric C-reactive protein (mCRP), dissociated form native, pentameric (pCRP), associated enhanced pro-inflammatory responses system, leading to increased permeability potential disruption. Methods This study utilized...
(1) Background: The surgical procedure to create an arteriovenous fistula (AVF) can be performed in either ambulatory or in-patient hospital setting, depending on the case’s complexity, anesthesia type used, and patient’s comorbidities. main scope of this study is assess cost-effectiveness clinical implications surgically creating AVF both in-hospital settings. (2) Methods: We conducted a retrospective observational study, which we initially enrolled all patients with end-stage kidney...
Abstract Background Chronic limb-threatening ischemia (CLTI) represents the advanced stages of peripheral arterial disease (PAD) and is caused by atherosclerotic damage in lower limbs, having a greater risk major amputation. Aim The aim this study was to analyze impact systemic immune index (SII), inflammation response (SIRI), aggregate (AISI) on clinical severity long-term amputation among patients with CLTI after percutaneous transluminal angioplasty (PTA). Material Methods This...
Introduction: Pediatric patients with cardiac congenital diseases require heart valve implants that can grow their natural somatic increase in size. Current artificial valves perform poorly children and cannot grow; thus, living-tissue-engineered capable of sustaining matrix homeostasis could overcome the current drawbacks prostheses minimize need for repeat surgeries. Materials Methods: To prepare valves, we produced completely acellular ovine pulmonary by perfusion. We then collected...
Abstract Objective: Tissue integration of vascular grafts partially depends on the host response to injury, which immediately begins after implantation and restoration circulation. In an infected environment, inflammation changes incorporation patterns. The aim study was observe tissue process, in a normal environment. Methods: We have created experimental model by performing subfascial four types grafts, rats (woven Dacron ® , knitted silver coated expanded Polytetrafloroethylene - ePTFE)...
Purpose: Experimental investigation in human eyelids to confirm that exposing excised tarsal plates ultraviolet-A radiation can induce a stiffening effect through the riboflavin-photosensitized crosslinking of collagen. Methods: Thirteen from nonfrozen cadavers were irradiated with rays (365 nm wavelength) at an irradiance 75 mW/cm 2 for 3 minutes, equivalent fluence 13.5 J/cm , presence riboflavin derivative as photosensitizer. The tensile stress (strength) and Young’s modulus (stiffness)...
Abstract The reduction in mortality following acute myocardial infarction (AMI) is an important achievement of modern medicine. Despite this progress, AMI remains the most common cause heart failure (HF) and HF-related morbidity mortality. involvement innate immune response different stages after has at tracted attention recent years. With increasing range potential therapeutic compounds delivery vectors, need highly efficient experimental models increasing, to support further advancement...
Large bone defects are a medical concern as these often unable to heal spontaneously, based on the host repair mechanisms. In their treatment, tissue engineering techniques represent promising approach by providing guide for osseous regeneration. As bioactive glasses proved have osteoconductive and osteoinductive properties, aim of our study was evaluate histologic examination, differences in healing critical-sized calvarial filled with glass combined adipose-derived mesenchymal stem cells,...
Currently, microfracturing is the most commonly used cartilage repair procedure in defects. Our aim was to study mechanism of vivo case full-thickness articular damage knee using a three-dimensional matrix implanted without any preseeded cells defect. We also investigated whether platelet-rich plasma application after microfracture associated with improved outcome compared traditional treatment alone rabbit model. Histological examination chondral defects, revealed largest amount new tissue...
Inadvertent intravascular injection of local anesthetics (LA) during regional anesthesia causes Local Anesthetic Systemic Toxicity (LAST). Theories lipid rescue in the case LAST proved that administration lipids has beneficial effects. One possible mechanism action is based on lipophilic properties LA which allow plasma-free to be bound by molecules Lipid Emulsion (LE). The association LA–LE shuttled towards organs such as liver and kidneys, half-life shortened. main objective this...
Abstract Introduction: Local Anesthetic Systemic Toxicity (LAST) is the most feared local anesthesia accident. As cardiac arrest determined by LAST mostly refractory to known resuscitation protocols, due anesthetic blockade produced in cells, Lipid Emulsion (L.E) has been proved be beneficial resuscitating anesthetic. The aim for this presentation ease future studies on topic, ensure a starting point next related research and LE mechanism of action. Method : Under genaral we induced rat...
Abstract Background: Snake venom is a complex mixture of biologically active substances. Some peptides and proteins from snake have already demonstrated their therapeutically potential. The Naja haje, an Elapidae member, has been analyzed this point view. Understanding the fully biochemical role its enzymes determined scientists to find new separation identification methods. Objective: Our goal was develop optimal HPLC analytical method for haje components, known neurotoxic activity. In...