A5024794178- Neuroinflammation and Neurodegeneration Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Neonatal and fetal brain pathology
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and Mental Health
- Sepsis Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Morinda citrifolia extract uses
- Pregnancy and Medication Impact
- Maternal Mental Health During Pregnancy and Postpartum
- Long-Term Effects of COVID-19
- Blood Coagulation and Thrombosis Mechanisms
- Neonatal and Maternal Infections
National Center for Global Health and Medicine
2020-2025
Saitama Medical University
2025
Social Insurance Saitama Chuo Hospital
2025
Center for Global Health
2020-2023
National Center of Neurology and Psychiatry
2014-2023
The University of Tokyo
2014-2023
University of Tokyo Hospital
2020
Abstract Background We aimed to reveal the transmission rate of coronavirus disease 2019 (COVID‐19) and clinical features congenital neonatal COVID‐19 disclose efficacy maternally transferred antibodies by maternal vaccination against severe acute respiratory syndrome 2 (SARS‐CoV‐2). Methods This multicenter, prospective observational study included a comprehensive testing protocol with appropriate precautions. Mothers infants were enrolled classified into an active infection group (mothers...
Abstract Background Microglial cells play an important role in the immune system brain. Activated microglial are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression pathological lesions neonatal hypoxic-ischemic encephalopathy (nHIE) model LOX-1 is known to be activator of cytokines and chemokines through intracellular pathways. Here, we investigated a novel molecular mechanism gene transcription under...
Background and Purpose- oxLDL (oxidized low-density lipoprotein) has been known for its potential to induce endothelial dysfunction used as a major serological marker of oxidative stress. Recently, LOX-1 (lectin-like oxidized lipoprotein receptor-1), lectin-like receptor oxLDL, attracted attention in studies neuronal apoptosis stroke. We aim investigate the impact LOX-1-deficiency on spontaneous hypertension-related brain damage present study. Methods- generated deficient strain genetic...
Neonatal hypoxic-ischemic encephalopathy (HIE) remains a serious burden in neonatal care. Hypothermia provides good outcome some babies with HIE. Here, we investigated the biological mechanisms of its neuroprotective effect and sought for new therapeutic target. We made HIE rats subjected them to hypothermia at 28°C 3 hours. pathologically confirmed efficacy against brain. To clarify molecular mechanism hypothermia's efficacy, analyzed mRNA expression, immunoassay, pathology brain or without...
The COVID-19 pandemic required our pediatric health care staff to adjust many irregularities and solve serious issues in routine clinical practice. In outpatient clinics, children exhibited common cold symptoms that mimic COVID-19, thus we initially screened patients via an interview form, then later SARS-CoV-2 antigen test. Cluster infections were entirely avoided by following systematic, everyday precautions. Patientsquality of life has been difficult maintain during the pandemic, due...
Background: Coronavirus disease 2019 (COVID-19) has been a serious pandemic. Vertical transmission of COVID-19 reported, but the rate is unclear, and clinical features congenital neonatal are poorly understood. Maternal vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recommended, efficacy maternally transferred antibodies unknown.Methods: This multicentre, prospective observational study included comprehensive testing protocol with appropriate precautions....
Abstract Background: Microglial cells play an important role in the immune system brain. Activated microglial are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression pathological lesions neonatal hypoxic-ischemic encephalopathy model LOX-1 is known to be activator of cytokines and chemokines through intracellular pathways. Here, we investigated a novel under hypoxic ischemic conditions. Methods: isolated...