Lowrey Peyton
A5061184764- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Herpesvirus Infections and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Galectins and Cancer Biology
- Influenza Virus Research Studies
- Immune responses and vaccinations
- COVID-19 Clinical Research Studies
National Institutes of Health
2022-2024
Dartmouth Hospital
2024
Dartmouth College
2024
National Institute of Allergy and Infectious Diseases
2022-2023
An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. However, the basis for such cross-protection at molecular level incompletely understood. Here, we characterized repertoire and epitope specificity antibodies elicited by Beta, Gamma WA1 ancestral variants assessed their cross-reactivity to these more recent Delta Omicron We developed method obtain immunoglobulin sequences concurrent rapid production functional assessment...
Abstract As SARS-CoV-2 variants continue evolving, testing updated vaccines in non-human primates remains important for guiding human clinical practice. To date, such studies have focused on antibody titers and antigen-specific B T cell frequencies. Here, we extend our understanding by integrating innate adaptive immune responses to mRNA-1273 vaccination rhesus macaques. We sorted cells from a pre-vaccine time point, as well peripheral two weeks after each of vaccine doses used single-cell...
Eliciting broad and durable antibody responses against rapidly evolving pathogens like influenza viruses remains a formidable challenge
SUMMARY Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 CD4-binding site (CD4bs) occur infrequently in macaques and humans have not been reproducibly elicited any outbred animal model. To address this challenge, we first isolated RHA10, an infection-induced rhesus bNAb with 51% breadth. The cryo-EM structure of RHA10 envelope (Env) resembled prototypic human CD4bs bNAbs CDR-H3-dominated binding. Env-antibody co-evolution revealed transient elimination two Env CD4bs-proximal...
An important consequence of infection with a SARS-CoV-2 variant is protective humoral immunity against other variants. The basis for such cross-protection at the molecular level incompletely understood. Here we characterized repertoire and epitope specificity antibodies elicited by Beta, Gamma ancestral assessed their cross-reactivity to these more recent Delta Omicron We developed high-throughput approach obtain immunoglobulin sequences produce monoclonal functional assessment from single B...