A5111232482- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease and Transplantation
- Diabetes Treatment and Management
- MRI in cancer diagnosis
- Cryospheric studies and observations
- Natural Language Processing Techniques
- Asthma and respiratory diseases
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Health Systems, Economic Evaluations, Quality of Life
- Radiomics and Machine Learning in Medical Imaging
- Heart Rate Variability and Autonomic Control
- Climate change and permafrost
- Arctic and Antarctic ice dynamics
- Vascular Malformations Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Moyamoya disease diagnosis and treatment
- Cancer Risks and Factors
- Cerebrovascular and genetic disorders
- Air Quality and Health Impacts
- Neurological diseases and metabolism
- Precipitation Measurement and Analysis
Lanzhou Jiaotong University
2024-2025
Capital Medical University
2019-2025
Beijing Jishuitan Hospital
2025
Peking University
2025
First Affiliated Hospital of Zhengzhou University
2023-2024
People’s Hospital of Rizhao
2023-2024
SingHealth
2020-2024
Duke-NUS Medical School
2020-2024
Zhengzhou University
2023-2024
GS Engineering (United States)
2024
Background and Purpose: Edaravone dexborneol, comprised of 2 active ingredients, edaravone (+)-borneol, has been developed as a novel neuroprotective agent with synergistic effects antioxidant anti-inflammatory in animal models. The present clinical trial aimed at testing the dexborneol versus on 90-day functional outcome patients acute ischemic stroke (AIS). Methods: A multicenter, randomized, double-blind, comparative, phase III was conducted 48 hospitals China between May 2015 December...
Accumulating evidence suggests the pro-inflammatory cytokine interleukin-6 (IL-6) in tumor microenvironment may promote development of hepatocellular carcinoma (HCC). However, underlying mechanism remains largely unknown.The expression and promoter activity lncTCF7 were measured by quantitative real-time polymerase chain reaction (qRT-PCR) luciferase reporter assay. The function STAT3 binding site region was tested assay with nucleotide substitutions. to confirmed chromatin...
OBJECTIVE. We investigated in Liver Imaging Reporting and Data System category 5 (LR-5) observations whether imaging features, including LI-RADS could predict microvascular invasion (MVI) posthepatectomy recurrence high-risk adult patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS. retrospectively identified 149 who underwent 3-T MRI within 1 month before hepatectomy for HCC; 81 of no HCC were followed more than year. Tumors clear surgical margins confirmed each specimen....
Abstract Background While previous genome-wide association studies (GWAS) have identified multiple risk variants for migraine, there is a lack of evidence about how these contribute to the development migraine. We employed an integrative pipeline efficiently transform genetic associations identify causal genes Methods conducted proteome-wide study (PWAS) by combining data from migraine GWAS with proteomic human brain and plasma proteins that may play role in developing also combined novel...
Cuproptosis and disulfidptosis, recently discovered mechanisms of cell death, have demonstrated that differential expression key genes long non-coding RNAs (lncRNAs) profoundly influences tumor development affects their drug sensitivity. Clear renal carcinoma (ccRCC), the most common subtype kidney cancer, presently lacks research utilizing cuproptosis disulfidptosis-related lncRNAs (CDRLRs) as prognostic markers. In this study, we analyzed RNA-seq data, clinical information, mutation data...
BACKGROUNDMassive hepatocyte death is the core event in acute liver failure (ALF). Gasdermin D (GSDMD)-mediated pyroptosis a type of highly inflammatory cell death. However, role and its mechanisms expanding responses ALF are unclear. AIMTo investigate GSDMD-mediated through vitro vivo experiments. METHODSThe expression pathway-associated proteins tissues from patients injury model was examined by Western blot. GSDMD short hairpin RNA (shRNA) used to effects downregulation on monocyte...
Particulate matter, ambient particulate matter with an aerodynamic equivalent diameter ≤2.5 µm (PM2.5) is closely associated asthma, and a high-fat diet also risk factor for the condition. In many cities in China, exposure to PM2.5 consumption of coexist. The Th1/Th2 balance immunological foundation onset progression it more accurate describe asthma symptoms terms changes this balance. Therefore, aim study was investigate effects combined on immune. Given background, our examined diets...
Background Type 2 diabetes mellitus (T2DM) and its related complications represent a growing economic burden for many countries health systems. Diabetes can be prevented through better disease control, but there is large gap between the recommended treatment that patients actually receive. The of T2DM challenging because different comprehensive therapeutic targets individual variability patients, leading to need precise, personalized treatment. Objective aim this study was develop...
Ten-eleven translocation protein 3 (TET3) is one of the key enzymes in DNA demethylation which can be expressed liver tissues. However, clinical value TET3 for diagnosis and treatment chronic disease have not been reported previously. We investigated diagnostic accuracy serum as a non-invasive screening tool fibrosis. 212 patients with from were enrolled this study. Enzyme-linked immunosorbent assay was used to measure levels TET3. Receiver operating characteristics (ROC) determined examine...
Abstract Background Patients with Parkinson's disease (PD) have consistently demonstrated brain structure abnormalities, indicating the presence of shared etiological and pathological processes between PD structures; however, genetic relationship remains poorly understood. Objective The aim this study was to investigate extent architecture structural phenotypes (BSPs) identify genomic loci. Methods We used summary statistics from genome‐wide association studies conduct MiXeR...
Clear cell renal carcinoma (ccRCC) is associated with complex immune interactions. We conducted a comprehensive analysis of immune-related differentially expressed genes in patients ccRCC using data from The Cancer Genome Atlas and ImmPort databases. underwent functional pathway enrichment analysis, followed by COX regression combined LASSO to construct an risk prognostic model. model comprised 4 IRGs: CLDN4, SEMA3G, CAT, UCN. Patients were stratified into high-risk low-risk groups based on...
We assessed liver fibrosis using real-time shear-wave elastography (SWE) combined with biopsy (LB) for patients hepatitis B e antigen (HBeAg)-negative chronic (CHB) and alanine transaminase < 2 times the upper limit of normal virus DNA 2000 IU/ml.A total 107 met inclusion criteria. Real- ime SWE ultrasoundassisted biopsies were consecutively performed. Fibrosis was staged according to METAVIR scoring system. Analyses receiver operating characteristic curve performed calculate optimal area...
Abstract Background : We describe the development of a dynamic simulation modelling framework to support agile resource planning during COVID-19 pandemic. The takes into consideration evolution pandemic and rapidly evolving policies processes deal with ever-changing outbreak scenarios. Methods A specific use case based on short-term bed is described within proposed framework. model was calibrated against historical data for Singapore situation. time period calibration from 1st April till...
Patients with asthma in Singapore often have complex patient journeys, diagnosis and management across various primary speciality care settings. Real-world population health data is needed to identify gaps inform policies.