A5101783434- Cardiovascular Effects of Exercise
- Sports injuries and prevention
- Organ Transplantation Techniques and Outcomes
- Dementia and Cognitive Impairment Research
- Rheumatoid Arthritis Research and Therapies
- Renal Transplantation Outcomes and Treatments
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Transplantation: Methods and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Cardiac Arrest and Resuscitation
- Ectopic Pregnancy Diagnosis and Management
- Pelvic and Acetabular Injuries
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Lung Cancer Treatments and Mutations
- Biosimilars and Bioanalytical Methods
- Reproductive Health and Contraception
- Neurological Complications and Syndromes
- Neurological Disorders and Treatments
- Spondyloarthritis Studies and Treatments
- Biosensors and Analytical Detection
- Mechanical Circulatory Support Devices
- Liver Disease and Transplantation
- Appendicitis Diagnosis and Management
University of Salerno
2025
Vita-Salute San Raffaele University
2024
Ospedale di Bolzano
2019
Sapienza University of Rome
2018
Novartis (Italy)
2000-2006
Aichi University
2002
Novartis (Switzerland)
2002
University of Cincinnati
2001
AULSS 2 Marca Trevigiana
1997
This study was designed to assess the effects of rivastigmine (Exelon<sup>®</sup>) on cognitive functioning patients suffering from dementia with Lewy bodies. a prospective, multi-centre, randomised, double-blind, placebo-controlled exploratory conducted at sites in UK, Spain and Italy. The treatment period 20 weeks 3-week posttreatment follow-up. primary outcome measures were Cognitive Drug Research (CDR) computerised assessment system Neuropsychiatric Inventory. Testing prior...
Objectives. To describe the baseline demographic, neuropsychiatric and neurological data of a large selected clinical sample patients with dementia Lewy Bodies (DLB) from an international multicentre trial rivastigmine. examine usefulness Consensus Criteria for diagnosis DLB in different countries. Methods. Seventeen centres Spain, UK Italy recruited diagnosed clinically as probable according to recent (McKeith et al., 1996). A standard protocol including inclusion/exclusion criteria,...
Intensive physical exercise may cause increase oxidative stress and muscular injury in elite football athletes. The aim of this study was to exploit the effect cocoa polyphenols on injuries induced by intensive players. Oxidant/antioxidant status markers muscle damage were evaluated 24 players 15 controls. Furthermore, randomly assigned either a dark chocolate (>85% cocoa) intake ( n = 12) or control group for 30 days randomized controlled trial. Oxidative stress, antioxidant status,...
The COVID-19 lockdown had significant consequences on the mental health of millions people, leading to increasing prescription and use psychotropic drugs. Due lack data in current literature, this study aims estimate trends consumption anxiolytics, antipsychotics, antidepressants before during pandemic people South Italian region. We conducted a retrospective observational study, retrieving prescriptions dispensed pharmacies Basilicata region (South Italy) for period 2019–2021. presented...
In this randomized controlled trial started in October 1990, 354 cadaveric kidney transplant recipients were assigned to receive either cyclosporine (CsA) monotherapy (115 patients), CsA + steroids (117 or azathioprine (122 patients). The median follow-up was 85.1 mo. Thirty-one deaths occurred (infection, 12; cardiovascular disease, 11; neoplasia, 4; and others, 4), 65 grafts lost, mostly due acute (15) chronic rejection (50). cumulative graft half-life 18.1 yr. According the...
Liver transplantation has become established therapy for end-stage liver disease. Survival rates are satisfactory and the current challenge is implementation of cost-optimization policies.This study was a cost-outcome cost-determinant analyses in an Italian National Health Services unit. Collection data related to survival costs 235 adult transplant recipients from 1997 2000. Costs included consumption-related (e.g., diagnostics, medication) structure-related staff, general costs, overhead)...
Abstract Background : Coronary artery disease (CAD) of allografted hearts is the main cause late mortality after cardiac transplant, but its etiology still undetermined. Hypothesis This study was undertaken to evaluate relevance several risk factors, including cyclosporine (CsA) dose and blood CsA levels, incidence CAD. Methods In 163 heart transplants performed between November 1985 August 1994 at our Institution, CAD diagnosed by coronary angiography or postmortem examination. Patients in...
<h3>OBJECTIVES</h3> The three <i>x</i> ray assessors of the GRISAR study (blinded to treatment) gave consensual erosion and damage scores baseline 12 month radiographs 284 rheumatoid arthritis (RA) patients using different methods: single readings as patient chronological sequence rays), paired sequence), chronologically ordered readings. aim was evaluate which these reading procedures is most appropriate for clinical trials. <h3>METHODS</h3> progression obtained each procedure compared by...
Pulmonary function can be impaired as a long-term consequence of SARS-CoV-2 infection. The aim this study was to evaluate the effect infection on pulmonary function, exercise tolerance, and muscle strength in healthy middle-aged military outpatients according during period infection.A cross-sectional carried out from March 2020 November 2022 at Military Hospital "Celio" (Rome, Italy). If someone had diagnosis certified by molecular nasal swab if they performed tests, diffusion carbon...
This study aimed to compare neuromuscular fatigability of the elbow flexors and extensors between athletes with amputation (AMP) spinal cord injury (SCI) for maximum voluntary force (MVF) rate development (RFD). We recruited 20 para-athletes among those participating at two training camps (2022) Italian Paralympic veterans. Ten SCI (two tetraplegia eight paraplegia) were compared 10 (above knee, N = 3; below 6; forearm, 1). quantified MVF, RFD 50, 100, 150 ms, maximal (RFDpeak) before after...
The discovery of oncogenic mutations that drive the growth and progression Non-small-cell lung cancer (NSCLC) led to development a range molecular targeted therapies. Tyrosine kinase inhibitors (TKIs) improve overall outcome patients with oncogene addicted NSCLC, ensure better compliance treatment few side effects compared traditional chemotherapy. However, is still completely "drug-centric", in population who usually survive for long time desire regain their quality life. Despite an...
<h3>Background</h3> In a previous study it has been shown that, in patients with systemic sclerosis (SSc), the cumulative number of micro-haemorrhages (MH) and micro-thrombosis (MT), computed eight finger nailfold videocapillaroscopy (NVC), called NEMO score, was strongly predictive disease activity (DA) measured by means European Scleroderma Study Group (ESSG) score. Even giant capillaries (GC) correlated to lesser extent ESSG then modified (m) score proposed which combined presence MH/MT...
Abstract Funding Acknowledgements Type of funding sources: None. Background Intense and prolonged exercise training induces morpho-functional cardiac changes, known as "athlete’s heart". The physiologic nature this remodeling has been questioned data on reversibility remodeling, especially the right ventricle (RV), after suspension high intensity are scarce. Purpose To describe changes by echocardiography in a group Olympic athletes prior games (T1) years cessation their competitive athletic...
Background: In daily practice, distinguishing between the physiological cardiac remodeling in athletes, characterized by en-largement of left ventricle (LV), from initial stages dilated cardiomyopathy, may be challenging, particularly pres-ence a mild reduction systolic function. Aims: Aim study was to evaluate contractile reserve LV with stress (exercise) echocardiography athletes reduced ejection fraction (EF) at rest. Methods: The population comprised 27 elite (26 M and 1 F) - mean age:...
<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic, degenerative, disabling and costly disease, particularly in its early form. There evidence that cyclosporine A (CsA) disease modifying antirheumatic drug (DMARD) effective slowing down the joint damage progression of RA. <h3>Objectives</h3> To assess economic profile CsA. <h3>Methods</h3> TECHNIQUE: Incremental cost effectiveness analysis (CEA). PATIENTS AND DATA: collected from GRISAR study, multicenter, prospective, long-term,...
Abstract Funding Acknowledgements Type of funding sources: None. INTRODUCTION Right ventricular (RV) enlargement is a physiologic adaptation to long lasting athletic training. Its clinical implications for veteran athletes are poorly understood. In recent years, controversial data suggest an association between ultra-endurance exercise and RV cardiomyopathy similar arrhythmogenic (ACM). this context, the effects detraining have not been extensively studied yet. PURPOSE The aim study was...