A5067633417- Neural dynamics and brain function
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Proteoglycans and glycosaminoglycans research
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Glycosylation and Glycoproteins Research
- Protease and Inhibitor Mechanisms
- Nonlinear Dynamics and Pattern Formation
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Cell Adhesion Molecules Research
- Artificial Intelligence in Healthcare and Education
- Gender Diversity and Inequality
- Immune Response and Inflammation
- Probiotics and Fermented Foods
- Angiogenesis and VEGF in Cancer
- Infant Nutrition and Health
- Veterinary Equine Medical Research
- Retinal and Optic Conditions
- Management and Organizational Studies
- Influenza Virus Research Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Genomics and Phylogenetic Studies
- Adolescent Sexual and Reproductive Health
Walter Reed Army Institute of Research
2010-2025
Nanyang Technological University
2011-2024
Singapore Centre for Environmental Life Sciences Engineering
2019-2024
St George's, University of London
2022-2024
City St George's, University of London
2024
The University of Western Australia
2023
Baptist Memorial Hospital for Women
2023
King Edward Memorial Hospital
2023
UNSW Sydney
2023
Alzheimer's Association
2021
The troposphere constitutes the final frontier of global ecosystem research due to technical challenges arising from its size, low biomass, and gaseous state. Using a vertical testing array comprising meteorological tower aircraft, we conducted synchronized measurements parameters airborne biomass ( n = 480) in air column up 3,500 m. taxonomic analysis metagenomic data revealed differing patterns microbial community composition with respect time day height above ground. temporal spatial...
Thrombospondin-1 (TSP1) can inhibit angiogenesis by interacting with endothelial cell CD36 or proteoglycan receptors. We have now identified α3β1 integrin as an additional receptor for TSP1 that modulates and the in vitro behavior of cells. Recognition integrin–binding peptide from normal cells is induced after loss cell–cell contact ligation CD98. Although confluent do not spread on a substrate, mediates efficient spreading substrates deprived vascular cadherin signaling. Activation this...
Shigellosis accounts for substantial morbidity and mortality worldwide is the second most common cause of moderate severe diarrhoea in children.This phase 2b study (NCT03527173), conducted between August 2018 November 2019, evaluated vaccine efficacy (VE), safety, immunogenicity a Shigella sonnei GMMA candidate (1790GAHB) adults, using S. 53 G controlled human infection model. Participants (randomized 1:1) received two doses 1790GAHB or placebo (GAHB-Placebo), at day (D) 1 D29, an oral...
Introduction Implementing artificial intelligence (AI) in healthcare, particularly primary care settings, raises crucial questions about practical challenges and opportunities. This study aimed to explore the perspectives of general practitioners (GPs) on impact AI care. Methods A convenience sampling method was employed, involving a hybrid workshop with 12 GPs 4 GP registrars. Verbal consent obtained, audio recorded. Thematic analysis conducted recorded data contemporaneous notes identify...
Objective Evidence indicates that multistrain probiotics benefit preterm infants more than single-strain (SS) probiotics. We assessed the effects of SS versus triple-strain (TS) probiotic supplementation (PS) in extremely (EP) infants. Design EP (gestational age (GA) <28 weeks) were randomly allocated to TS or probiotic, assuring blinding. Reference (REF) group was placebo arm our previous trial. PS commenced with feeds and continued until 37 weeks’ corrected GA. Primary outcome time full...
Purpose Based on authentic leadership (AL) theory and research lesbian, gay, bisexual transgender (LGBT) workplace experiences, this study proposes that AL explains variance beyond transformational (TL) in attitudinal outcomes for LGBT managers compared to non-LGBT managers. It is further predicted core self-evaluations (CSEs) bound relationships between AL, status outcomes. Design/methodology/approach A time-lagged survey of 193 218 (i.e. heterosexual cisgender) was conducted. The first...
Shigella is a major cause of moderate to severe diarrhea largely affecting children (<5 years old) living in low- and middle-income countries. Several vaccine candidates are development, controlled human infection models (CHIMs) can be useful tools provide an early assessment efficacy potentially support licensure. A lyophilized strain S. sonnei 53G was manufactured evaluated establish dose that safely reproducibly induced ≥60% attack rate. Samples were collected pre- postchallenge assess...
Shigella is an important cause of diarrhea worldwide, and efforts are ongoing to produce a safe effective vaccine. Although clear immune correlate protection has not been established, antibodies with bactericidal capacity may provide one means protecting against shigellosis. Thus, it measure the functional antibodies, as opposed only binding activity. This article describes simple, robust, high-throughput serum assay capable measuring -specific in vitro . We show for first time that this was...
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Abstract The extant literature on authentic leadership (AL) has neglected to consider how the experience of AL may be particularly challenging for minoritized leaders. This research advances knowledge by contextualizing lesbian, gay, bisexual and transgender (LGBT) leaders who represent a unique group. Using qualitative data from 23 LGBT individuals in various positions, we examine, via an abductive approach, they try enact within their role. Our first contribution, developed through...
// Daniel J. O'Shannessy 1 , Elizabeth B. Somers Lakshmi K. Chandrasekaran 2 Nicholas C. Nicolaides Jennifer Bordeaux and Mark D. Gustavson Department of Translational Medicine Diagnostics, Morphotek Inc., Exton, PA HistoRx Inc. (A subsidiary Genoptix Medical Laboratory, Inc.), Carlsbad, CA Correspondence: O'Shannessy, email: Keywords : Endosialin, TEM-1, CRC, tumor microenvironment, prognosis Received April 20, 2014 Accepted June 14, Published 16, Abstract Tumor survival is influenced by...
Alzheimer's disease (AD) and all other dementia represent a global challenge, with an estimated 50 million individuals in the world living today. In low middle income countries (LMICs), burden of often is greater, some these are projected to have largest increases prevalence during next few decades. As world's voluntary health organization dedicated AD dementia, Association committed its vision without recognizes needs, challenges, opportunities for research parts world, especially LMICs....
Shigella spp. infection contributes significantly to the global disease burden, primarily affecting young children in developing countries. Currently, there are no FDA-approved vaccines against Shigella, and prevalence of antibiotic resistance is increasing, making therapeutic options limited. Live-attenuated vaccine strains WRSs2 (S. sonnei) WRSf2G12 flexneri 2a) highly immunogenic, them promising candidates, but possess an inflammatory lipid A structure on their lipopolysaccharide (LPS;...
How stable synchrony in neuronal networks is sustained the presence of conduction delays an open question. The Dynamic Clamp was used to measure phase resetting curves (PRCs) for entorhinal cortical cells, and then construct two such neurons. PRCs were general Type I (all advances or all delays) weakly type II with a small region at early phases opposite resetting. We previously developed theoretical methods based on under assumption pulsatile coupling predict that synchronize these hybrid...
Treatment of viral infections continues to be elusive owing the variance in virus structure (RNA, DNA, and enveloped nonenveloped viruses) together with their ability rapidly mutate garner resistance. Here we report a general strategy prevent infection using multifunctional macromolecules that were designed have mannose moieties compete viruses for immune cells, basic amine groups block entry through electrostatic interactions replication by neutralizing endosomal pH. We showed cells treated...
Controlled human infection models (CHIMs) are useful for vaccine development. To improve on existing models, we developed a CHIM using lyophilized preparation of Shigella sonnei strain 53G produced current good manufacturing practice (cGMP). Healthy adults were enrolled in an open-label dose-ranging study. Following administration dose rehydrated S. 53G, subjects monitored development disease. The first cohort received 500 CFU and dosing subsequent cohorts was based results from the previous...
The large, aggregating chondroitin sulphate proteoglycan of cartilage, aggrecan, has served as a generic model structure. Molecular cloning aggrecans further defined their amino acid sequences and domain structures. In this study, we have obtained the complete coding sequence chicken sternal cartilage aggrecan by combination cDNA genomic DNA sequencing. composite is 6117 bp in length, encoding 1951 acids. Comparison protein primary structure with rat, human bovine disclosed both similarities...
Antiangiogenic and antiproliferative effects of synthetic D-reverse peptides derived from the type 1 repeats thrombospondin (TSP1) [1,2] were studied in rodent C6 glioma 9L gliosarcomas. To directly measure tumor size vascular parameters, we employed vivo magnetic resonance (MR) imaging corroborated results by traditional morphometric tissue analysis. Rats bearing either or tumors treated with TSP1-derived peptide (D-reverse amKRFKQDGGWSHWSPWSSac, n=13) a control am KRAKQAGGASHASPASSac,...
A central problem in cortical processing including sensory binding and attentional gating is how neurons can synchronize their responses with zero or near-zero time lag. For a spontaneously firing neuron, an input from another neuron delay advance the next spike by different amounts depending upon timing of relative to previous spike. This information constitutes phase response curve (PRC). We present simple graphical method for determining effect PRC shape on synchronization tendencies...
We used optical imaging with voltage-sensitive dyes (VSDs) to investigate the spatio-temporal dynamics of synaptically-evoked activity in brain slices inferior colliculus (IC). Responses transverse which preserve cross-frequency connections and modified sagittal that within frequency laminae were evoked by activating lateral lemniscal tract. Comparing between small large populations cells revealed response areas central nucleus IC similar magnitude but graded temporally. In sections, these...
The proteoglycan, aggrecan has a globular domain, G1, at the N terminus and different G3, C terminus. Aggrecan produced by mutant nanomelic chickens is truncated due to premature stop codon consequently lacks G3 minor portion of its chondroitin sulfate domain (Li, H., Schwartz, N. B., Vertel, B. M. (1993) J. Biol. Chem. 268, 23504-23511). protein retained in endoplasmic reticulum fails enter Golgi stacks (Vertel, M., Walters, L. Grier, Maine, N., Goetinck, P. F. Cell Sci. 104, 939-948)....