A5083613014- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cystic Fibrosis Research Advances
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Pediatric health and respiratory diseases
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Gut microbiota and health
- Neuroscience of respiration and sleep
- Asthma and respiratory diseases
- Cardiovascular and Diving-Related Complications
- Neonatal Respiratory Health Research
- Inhalation and Respiratory Drug Delivery
- Airway Management and Intubation Techniques
- Respiratory and Cough-Related Research
- Nosocomial Infections in ICU
- Antifungal resistance and susceptibility
- Studies on Chitinases and Chitosanases
- Infectious Diseases and Tuberculosis
- Innovations in Medical Education
- Sleep and related disorders
- Lymphatic Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Global Health Workforce Issues
- Medical and Biological Ozone Research
Singapore General Hospital
2016-2025
Duke-NUS Medical School
2015-2025
SingHealth
2025
SingHealth Duke-NUS Academic Medical Centre
2024
Nanyang Technological University
2022
National Heart Centre Singapore
2016
Understanding the composition and clinical importance of fungal mycobiome was recently identified as a key topic in “research priorities” consensus statement for bronchiectasis. Patients were recruited part CAMEB study: an international multicentre cross-sectional Cohort Asian Matched European Bronchiectasis patients. The determined 238 patients by targeted amplicon shotgun sequencing 18S–28S rRNA internally transcribed spacer regions ITS1 ITS2. Specific quantitative PCR detection conidial...
This article was migrated. The marked as recommended. COVID-19 pandemic has presented significant challenges for medical schools. It is critical to ensure final year school students are not delayed in their entry the clinical workforce times of healthcare crisis. However, proceeding with assessment determine competency graduation from school, and maintaining performance standards graduating doctors an unprecedented challenge under conditions. hitherto uncharted territory schools there scant...
Rationale: Long-term antibiotic use for managing chronic respiratory disease is increasing; however, the role of airway resistome and its relationship to host microbiomes remains unknown.Objectives: To evaluate resistomes relate them environmental using ultradeep metagenomic shotgun sequencing.Methods: Airway specimens from 85 individuals with without (severe asthma, obstructive pulmonary disease, bronchiectasis) were subjected sequencing an average depth exceeding 20 million reads....
The ROX index (ratio of pulse oximetry/FIO2 to respiratory rate) has been validated predict high flow nasal cannula therapy (HFNC) outcomes in patients with pneumonia. We evaluated a modified incorporating heart rate (HR) initiated on HFNC for acute hypoxemic failure and as preventative treatment following planned extubation.We performed prospective observational cohort study 145 treated HFNC. ROX-HR was defined the ratio over HR (beats/min), multiplied by factor 100. Evaluation using area...
Neisseria species are frequently identified in the bronchiectasis microbiome, but they regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bacteriomes defined by presence spp. associate with poor clinical outcomes, including exacerbations. subflava cultivated from patients promotes loss epithelial integrity inflammation primary cells. In vivo models infection metabolipidome analysis highlight...
Allergic sensitization is associated with poor clinical outcomes in asthma, chronic obstructive pulmonary disease, and cystic fibrosis; however, its presence, frequency, significance non-cystic fibrosis bronchiectasis remain unclear.To determine the frequency geographic variability that exists a pattern to common specific allergens, including house dust mite fungi, correlate such patterns airway immune-inflammatory status bronchiectasis.Patients were recruited Asia (Singapore Malaysia)...
BACKGROUND There is limited data on long term Continuous Positive Airway Pressure (CPAP) adherence in Southeast Asian countries. This a prospective study CPAP among Obstructive sleep apnea (OSA) patients privately funded healthcare system. METHODS Patients with moderate-severe OSA who had been initiated at least one year previously were contacted for scripted telephone interview to assess compliance and factors associated adherence. RESULTS Of 135 consecutive diagnosed have moderate severe...
Sensitisation to
A major challenge with the treatment of obstructive sleep apnoea (OSA) is adherence to continuous positive airway pressure (CPAP) therapy. Mask tolerability an important determinant adherence, however evidence guide selection mask interfaces lacking.We conducted a randomized crossover trial in CPAP therapy for moderate-to-severe OSA assess and efficacy nasal mask, pillow oronasal masks. Demographic data, Nasal Obstruction Symptom Evaluation (NOSE) scores craniofacial measurements were also...
Introduction: This study assessed the clinical utility of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) for diagnosis suspected granulomatous mediastinal lymphadenopathy. Materials and Methods: Retrospective chart review all patients who underwent EBUS-TBNA lymphadenopathy at Singapore General Hospital between December 2008 2011 inclusive. Results: Over a period 3 years, total 371 whom 33 (9%) had procedure performed evaluation — 18 tuberculosis (TB)...
Spirometry is a useful tool in assessing the physiological lung function of patient, and can be helpful differentiating etiology patient's symptoms. Indications for test actual procedure are as described. Validity spirometry depends on patient co-operation criteria acceptability repeatability must met interpretation results. Commonly measured parameters described simple logarithm result given. Physicians mindful when interpreting context extreme ages, size or differing ethnicity reference...
Abstract Background and Objective While the lung microbiome in severe asthma has been studied, work employed targeted amplicon‐based sequencing approaches without functional assessment with none focused on multi‐ethnic Asian populations. Here we investigate clinical relevance of microbial phenotypes Asians using metagenomics. Methods Prospective clinical, radiological, immunological measures were performed a cohort ( N = 70) recruited across two centres Singapore. Sputum was subjected to...