A5047315427- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Congenital Heart Disease Studies
- Renal Transplantation Outcomes and Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiovascular and exercise physiology
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Valve Diseases and Treatments
- Analytical Chemistry and Sensors
- Anesthesia and Sedative Agents
- Coordination Chemistry and Organometallics
- Congenital Diaphragmatic Hernia Studies
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
Vanderbilt University Medical Center
2024-2025
Background: Heart transplantation (HT) is the definitive therapy for end-stage heart failure. However, with improving post-HT survival in modern era, recipients are increasingly cumulatively exposed to unique risk factors cardiovascular-kidney-metabolic (CKM) dysfunction. An expanded understanding of incidence and prevalence CKM dysfunction may inform screening therapeutic strategies mitigate adverse events. Objectives: The aim this study was characterize adult pediatric HT at a high-volume...
ABSTRACT Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current approaches to diagnosis rely on histology, which exhibits wide diagnostic variability lacks access molecular phenotypes that may stratify therapeutic response. Here, we leverage image-based spatial transcriptomics at sub-cellular resolution in longitudinal human cardiac biopsies characterize transcriptional heterogeneity 62 adult pediatric heart transplant (HT)...
Secondary mitral regurgitation (SMR), classified as ventricular or atrial SMR, is associated with excess mortality, heart failure (HF) hospitalization, and worsening quality of life. Therapy directed toward the underlying cardiomyopathy first use neurohormonal antagonism, cardiac resynchronization therapy arrhythmia reduction, which can reduce MR severity improve outcomes, followed by transcatheter therapies. Multimodality imaging in evaluation critical to determine mechanism, severity,...