A5045723807- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Tuberculosis Research and Epidemiology
- Immunotherapy and Immune Responses
- Infectious Diseases and Tuberculosis
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Diagnosis and treatment of tuberculosis
Karolinska University Hospital
2022-2024
Karolinska Institutet
2022-2024
Abstract During the COVID-19 pandemic it was widely described that certain individuals infected by SARS-CoV-2 experience persistent disease signs and symptoms, Long COVID, which in some cases is very severe with life changing consequences. To maximize our chances of identifying underpinnings this illness, we have focused on 121 most from >1000 patients screened specialized clinics Sweden Belgium. We restricted study to subjects objective measures organ damage or dysfunction, >3 months...
Abstract Tuberculosis (TB) remains a major global health challenge, with approximately 25% of the population estimated to have been infected causative pathogen Mycobacterium tuberculosis (Mtb) . Current diagnostic methods based on Interferon-gamma (IFNγ) release assays (IGRA) limitations in detecting infection and cannot distinguish those TB from disease. In this study, we evaluated multiplex FluoroSpot assay measuring IFNγ, TNF, IL2-secreting cells response Mtb antigens ESAT-6, CFP-10,...
Abstract CD11c, FcRL5, or T‐bet are commonly expressed by B cells expanding during inflammation, where they can make up >30% of mature cells. However, the association between proteins and differentiation function in host response remains largely unclear. We have assessed co‐expression T‐bet, FcRL5 an vitro B‐cell culture system to determine how stimulation via BCR, toll‐like receptor 9 (TLR9), different cytokines influence expression. observed expression dynamics for all markers, but a...
Abstract CD11c, FcRL5, or T-bet are commonly expressed by B cells expanding during inflammation, where they can make up >30% of mature cells. However, the association between proteins and differentiation function in host response remain largely unclear. We have assessed co-expression FcRL5 an vitro cell culture system to determine how stimulation via receptor (BCR), toll-like 9 (TLR9), different cytokines influence T-bet, expression. observed expression dynamics for all markers, but a...
ABSTRACT Infection with Mycobacterium tuberculosis remains a global health challenge, diverse clinical outcomes ranging from latent TB (LTB) infection to active disease (ATB). We conducted comprehensive analysis of NK cell subsets and function in individuals LTB, ATB, healthy controls elucidate their potential association pathogenesis. Peripheral blood mononuclear cells (PBMCs) were isolated Mtb-infected analyzed by mass cytometry flow cytometry. identified distinct evaluated functional...