A5025965095- Molecular Biology Techniques and Applications
- Tuberculosis Research and Epidemiology
- Insect Resistance and Genetics
- Traditional Chinese Medicine Studies
- Rheumatoid Arthritis Research and Therapies
- Plant biochemistry and biosynthesis
- interferon and immune responses
- Pharmacological Effects of Natural Compounds
- Machine Learning in Bioinformatics
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Transgenic Plants and Applications
- Phytochemical compounds biological activities
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023
South China Agricultural University
2020-2023
China Three Gorges University
2023
Background. Tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, affects approximately one-quarter of global population and is considered one most lethal infectious diseases worldwide. The prevention latent tuberculosis infection (LTBI) from progressing into active (ATB) crucial for controlling eradicating TB. Unfortunately, currently available biomarkers have limited effectiveness in identifying subpopulations that are at risk developing ATB. Hence, it imperative to...
Maintenance of proteome integrity is essential for cell function and survival in changing cellular environmental conditions. The endoplasmic reticulum (ER) the major site synthesis secretory membrane proteins. However, accumulation unfolded or misfolded proteins can perturb ER protein homeostasis, leading to stress compromising function. Eukaryotic organisms have evolved sophisticated conserved quality control systems ensure folding fidelity via response (UPR) eliminate potentially harmful...
Abstract Background:Before studying gene expression of different organisms, it is important to determine the best reference gene. At present, most accurate method detecting quantitative real-time PCR (RT-qPCR). With this method, genes that are stable in biological systems and under conditions can be obtained. Toona ciliata Roem ( T. ). a valuable fast-growing timber specie. In study, 20 were identified using RT-qPCR, as primary prerequisite for future analysis. Four methods, geNorm,...
The material basis and mechanism of Chaenomelis Fructus in the treatment rheumatoid arthritis(RA) were explored by network pharmacology, potential anti-RA targets verified molecular docking animal experiments. active components searched against Traditional Chinese Medicine System Pharmacology Database Analysis Platform. GeneCards, DisGeNET, OMIM used to obtain RA-related targets. common shared RA considered as RA. Cytoscape 3.9.0 was employed establish a "traditional medicine-active...
Abstract Background: Before studying gene expression of different organisms, it is important to determine the best reference gene. At present, most accurate method detecting quantitative real-time PCR (RT-qPCR). With this method, genes that are stable in biological systems and under conditions can be obtained. Toona ciliata Roem ( T. ). a valuable fast-growing timber specie. In study, 20 were identified using RT-qPCR, as primary prerequisite for future analysis. Four methods, geNorm,...
Abstract Background: Before studying the gene expression of different organisms, it is important to determine best reference gene. At present, most accurate method for detecting quantitative real-time PCR(RT-qPCR). By using this method, genes that are stable in biological systems and under conditions can be obtained. Toona ciliata Roem ( T. ). a valuable fast-growing timber species. In study, 20 were identified through RT-qPCR, as primary prerequisite future analysis. Four methods, geNorm,...
Abstract Background: Before studying gene expression of different organisms, it is important to determine the best reference gene. At present, most accurate method detecting quantitative real-time PCR (RT-qPCR). With this method, genes that are stable in biological systems and under conditions can be obtained. Toona ciliata Roem ( T. ). a valuable fast-growing timber specie. In study, 20 were identified using RT-qPCR, as primary prerequisite for future analysis. Four methods, geNorm,...
Abstract Background Toona ciliata is a traditional woody plant that can be used as medicinal material in China. The extracts of roots, stems, leaves, and flowers all have wide range bioactivities. However, T. has been facing an unresolved pest problem caused by Hypsipyla robusta Moore (HRM), which seriously affects its growth development. Results In this study, transcriptome sequencing young stems was eaten HRM for 0, 3, 12, 21h were performed. A large number differentially expressed genes...