A5110427447- Hemophilia Treatment and Research
- Occupational Health and Performance
- Blood Coagulation and Thrombosis Mechanisms
- Healthcare professionals’ stress and burnout
- Resilience and Mental Health
- Multiple Sclerosis Research Studies
- Workplace Health and Well-being
- Platelet Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Posttraumatic Stress Disorder Research
- Cancer-related molecular mechanisms research
- Urological Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Tissue Engineering and Regenerative Medicine
- Urinary Bladder and Prostate Research
- Sexual function and dysfunction studies
- Kidney Stones and Urolithiasis Treatments
- Chronic Myeloid Leukemia Treatments
- Defense, Military, and Policy Studies
- Planarian Biology and Electrostimulation
- Medicinal plant effects and applications
- Cancer Risks and Factors
- Endoplasmic Reticulum Stress and Disease
- Neuropeptides and Animal Physiology
- Pregnancy and Medication Impact
Tongji Hospital
2010-2025
Huazhong University of Science and Technology
2010-2025
University of California, San Francisco
2019-2020
Stanford University
2020
Urology San Antonio
2020
Sanofi (United States)
2020
Biogen (United States)
2013-2016
Naval Health Research Center
1999-2004
University of Pittsburgh
1996
State University of New York
1993
Once-weekly efanesoctocog alfa provides high sustained factor VIII activity with superior bleeding prevention as compared prestudy prophylaxis in previously treated patients 12 years of age or older severe hemophilia A. Data on outcomes treatment children younger than A are limited.
Abstract Introduction The efficacy and safety of recombinant factor VIII Fc fusion protein (rFVIIIFc) as an extended half‐life treatment for severe haemophilia A were demonstrated in the Phase 3 A‐LONG Kids studies. Eligible subjects who completed could enrol ASPIRE (NCT01454739), open‐label extension study. Aim To report long‐term rFVIIIFc with enrolled ASPIRE. Methods Previously treated received one or more following regimens: individualized prophylaxis (IP), weekly prophylaxis, modified...
Abstract Introduction Recombinant factor IX Fc fusion protein (rFIXFc) has demonstrated efficacy for treatment of haemophilia B in the Phase 3 B‐LONG and Kids studies. However, long‐term rFIXFc safety data have not yet been reported. Aim To report subjects with B. Methods B‐YOND (NCT01425723) was an open‐label extension eligibl previously treated who completed or B‐LONG. Subjects received ≥1 regimen: weekly prophylaxis (WP), individualized interval (IP), modified episodic treatment. could...
Summary The safety, efficacy, and prolonged half-life of recombinant factor IX Fc fusion protein (rFIXFc) were demonstrated in the Phase 3 B-LONG (adults/adolescents ≥12 years) Kids (children <12 studies subjects with haemophilia B (≤2 IU/dl). Here, we report interim, long-term safety efficacy data from B-YOND, rFIXFc extension study. Eligible who completed or could enrol B-YOND. There four treatment groups: weekly prophylaxis (20–100 IU/kg every 7 days), individualised (100 8–16 modified...
Abstract Background Castration-resistant prostate cancer (CRPC) has been a major cause of tumor-associated death among men worldwide. The discovery novel therapeutic medicines for CRPC remains imperative. Atractylenolide I (ATR-I), prominent bioactive component from Atractylodes macrocephala, exhibits powerful anticancer potentials in various malignancies. Nevertheless, the ATR-I’s activity on not reported. Methods An enzalutamide-resistant (EnzR) cell line was successfully constructed....
Background: This study examines the prevalence and correlates of self-reported premenstrual symptoms among a large, population-based sample reproductive age, active-duty women. Methods: Data were obtained from combined dataset two large-scale mail surveys designed to represent total force. Subjects included in present 6026 activeduty women all branches military service stratified by service, paygrade group, race/ethnicity, location. A multivariate approach is used evaluate interrelationships...
The 1995 Perceptions of Wellness and Readiness Assessment was designed to provide baseline health risk-factor information on the physical mental status women in U.S. Navy Marine Corps make comparisons both within military subpopulations with civilian populations. A population-based, multi-stage, cluster sample 782 active duty men were administered a structured computerized telephone interview Diagnostic Statistical Manual-III-R psychiatric diagnoses. Estimates 40 21% for overall lifetime...
The prevalence of lifetime exposure to violence, natural disaster, or major accidents involving injuries fatalities was examined in the largest population-based epidemiologic survey U.S. military personnel date. psychosocial and health effects types experience (witness only, victim/survivor, relief worker), gender differences, social support were also evaluated. Over 15,000 active duty from stratified random samples all services responded either mail questionnaires and/or worksite surveys....
Overweight females are prone to obesity-associated stress urinary incontinence (OA-SUI), and there no definitive medical therapies for this common urologic condition. This study was designed test the hypothesis that regenerative therapy restore urethral striated muscle (stM) pelvic floor muscles might represent a valuable therapeutic approach. For in vitro experiment, single-guide RNAs targeting myostatin (MSTN) were used CRISPRi/dCas9-Kruppel associated box (KRAB)-mediated gene silencing....
We have previously reported segregation analysis of alcoholism in 35 multigenerational families, each ascertained through a pair male alcoholics by using the mixed model implemented POINTER. This suggested that liability to was, part, controlled major effect with or without additional multifactorial effects. The hypothesis was explained single genetic locus strictly mendelian transmission rejected. purpose present use regressive REGD program from Statistical Analysis for Genetic Epidemiology...
OBJECTIVE: To present data from animal reproductive toxicology studies and pregnancy outcomes reported during the BG-12 (dimethyl fumarate) clinical development program.
OBJECTIVE: Describe the clinical relevance of lymphocyte count reductions associated with delayed-release dimethyl fumarate (DMF), based on an integrated analysis placebo-controlled Phase 2b, DEFINE, and CONFIRM studies. BACKGROUND: Delayed-release DMF demonstrated significant efficacy acceptable safety profile in trials. Adverse events included flushing gastrointestinal events, as well a reduction counts. DESIGN/METHODS: This comprised 2,428 RRMS patients randomized to receive placebo...
OBJECTIVE: To report interim safety results (as of 30 March 2012) from ENDORSE, an ongoing 5-year extension DEFINE and CONFIRM.
With the recent increase in women's representation military, baseline physical measurement data are needed to help set appropriate accession and retention standards design useful prevention intervention programs areas of fitness health. This study incorporated several body composition indices obtain anthropometric for a representative sample 1,292 active duty Navy Marine Corps women men. It also assessed extent which personnel met weight-for-height fat standards. The prevalence overweight...