A5100707282- Proteoglycans and glycosaminoglycans research
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Diverse Scientific Research Studies
- Cancer-related molecular mechanisms research
- Biomarkers in Disease Mechanisms
- Oral and Maxillofacial Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Immune cells in cancer
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Phytochemicals and Medicinal Plants
- Advanced Glycation End Products research
- Polysaccharides and Plant Cell Walls
- Ethnobotanical and Medicinal Plants Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Diagnosis and Treatment
- S100 Proteins and Annexins
- NF-κB Signaling Pathways
- Cancer Research and Treatments
Aichi Medical University
2022-2024
Institute for Molecular Science
2022-2024
Chittaranjan National Cancer Institute
2020
University of Chittagong
2017
Abstract Serum from one hundred and ten breast cancer patients thirty healthy female volunteers, were prospectively collected evaluated for serum levels of Shh IL-6 using human specific enzyme-linked immunoassays. All regularly monitored event free survival (EFS) overall (OS). Overall outcome analysis was based on levels. In with progressive metastatic BC, both concentrations elevated in 44% (29 65) 63% (41 patients, respectively, at a statistically significant level [Shh (p = 0.0001)...
It has been reported that malaria is one of the most important vector-borne diseases in Jharkhand with significant morbidity and mortality. The National Vector Borne Disease Control Programme prepared new treatment guidelines for recommend phytochemical constituents-based therapy as first-line drug malaria. being observed cases resistance are increasing day by day. Finding antiplasmodial or antimalarial plant species to develop effective malarial drugs necessity time avoid problem...
Introduction: In Bangladesh government provision of primary care in rural areas has seen the development services for non-communicable diseases, particularly hypertension and diabetes (given their substantial rise recent decades). However, context cities, which are characterised by a plurality providers that have sprung up to meet demands rapidly growing urban population, such is very limited. Methods analysis: We will conduct mixed-methods study, based on RE-AIM framework, understand 1)...
The oral cavity and gut are the two largest microbial habitats in human body, playing a significant role microbiome‐associated diseases. Even though continuous regions connected through gastrointestinal tract, their microbiome profiles distinct due to oral–gut barrier. However, there instances where microbiota can translocate intestinal mucosa, especially conditions of barrier dysfunction. On other hand, transmission from occurs both interpersonal intrapersonal ways. These transmissions...
Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan that plays key role in the formation of provisional matrix. Here, we generated dextran sodium-induced colitis knockin-mice, R/R, expressing ADAMTS-resistant versican, and investigated impact accumulating versican its turnover inflammatory colon mucosa. Histologically, R/R showed decreased levels tissue destruction an increased number myofibroblasts macrophages. Characterization cells revealed increase F4/80+ macrophages...
Versican is a large chondroitin sulfate proteoglycan in the extracellular matrix. It plays pivotal role formation of provisional S100a4, previously known as fibroblast-specific protein, functions calcium channel-binding protein. To investigate versican expressed fibroblasts, we generated conditional knockout mice which expression deleted cells expressing S100a4. We found that S100a4 adipose tissues, and these exhibit obesity under normal diet, becomes apparent early five months. The white...
Abstract Malignant pleural mesothelioma (MPM) is an uncommon yet deadly cancer linked to asbestos exposure. The lack of effective early diagnosis and treatment leads reduced life expectancy among patients with MPM. This study aimed identify a novel molecular target inhibitor develop more therapeutics for Our drug screening assay showed that the fatty acid synthase (FASN) cerulenin demonstrates strong selective anti-proliferative properties against NF2/CDKN2A(p16) -deficient MPM cells,...
Three-dimensional cell culture creates an environment that allows cells to grow and interact with the surrounding extracellular framework. Versican plays a pivotal role in forming provisional matrix, but it is still unclear how this proteoglycan affects formation of matrix. Here, we established three-dimensional system using fibrin gel, which enables long-term up month. With system, characterized fibroblasts obtained from newborn knock-in homozygotes, termed R/R, expressing ADAMTS-resistant...
Being a tiny component, all the intra-cellular orchestra starting from exosome generation till its escape immune cells, is connected with biogenic dynamicity of molecular signaling in cells. The biogenesis exosomes follows endocytic pathway thereby releases intraluminal vesicles extracellular space. Exosomes play critical role oncogenic primary tumor microenvironment as well distant sites to make pre-metastatic niche (PMN) for cells cause future metastasis. Moreover, derived (TDEs) an...