A5092384743- Phytochemical and Pharmacological Studies
- Bioactive natural compounds
- Synthesis and biological activity
- Synthesis of Organic Compounds
- Cannabis and Cannabinoid Research
- Chemical synthesis and alkaloids
- Alkaloids: synthesis and pharmacology
- Advanced Drug Delivery Systems
- Psychedelics and Drug Studies
- Phytochemistry and Bioactive Compounds
- Phytochemical Studies and Bioactivities
University of Chemistry and Technology, Prague
2023-2024
Cannabidiol (CBD) is the non-psychoactive component of plant Cannabis sativa (L.) that has great anti-inflammatory benefits and wound healing effects. However, its high lipophilicity, chemical instability, extensive metabolism impair bioavailability clinical use. Here, we report on preparation a human cornea substitute in vitro validate this for evaluation drug penetration. CBD nanoemulsion was developed evaluated stability biological activity. The physicochemical properties were maintained...
In this work, we report the application of Buchwald-Hartwig amination for preparation new derivatives quercetin and luteolin. Our investigation delves into impact aniline moiety on antioxidant, anti-inflammatory activity, cytotoxicity, ability flavonoids to modulate drug-resistance mechanisms in bacteria. The activity disappeared after introduction cytotoxicity remained low. Although luteolin bacterial resistance antibiotics has already been published, is first molecular mechanism process....
Multidrug resistance is the major obstacle to cancer chemotherapy. Modulation of P-glycoprotein and drug combination approaches have been considered important strategies overcome resistance.
Abstract Lilial (also called lysmeral) is a fragrance ingredient presented in many everyday cosmetics and household products. The concentrations of lilial the final products rather low. Its maximum concentration was limited recently, its use prohibited EU due to classification as reproductive toxicant. Additionally, according European Chemicals Agency, it under assessment one potential endocrine disruptors, i.e. substance that may alter function system and, result, cause health problems....