A5057828755- Ethnobotanical and Medicinal Plants Studies
- Traditional and Medicinal Uses of Annonaceae
- Alkaloids: synthesis and pharmacology
- Chemical synthesis and alkaloids
- African Botany and Ecology Studies
- Cholinesterase and Neurodegenerative Diseases
- Phytochemistry and Biological Activities
- Psychedelics and Drug Studies
- Banana Cultivation and Research
- Essential Oils and Antimicrobial Activity
- Phytochemistry Medicinal Plant Applications
University of Lisbon
2014-2024
Multidrug resistance (MDR) is a major challenge in cancer chemotherapy. Aiming at generating small library of anticancer compounds for overcoming MDR, lycorine (1), Amaryllidaceae alkaloid isolated from Pancratium maritimum, was derivatized. Thirty-one new (2-32) were obtained by chemical transformation the hydroxyl groups into mono- and di-carbamates. Compounds 1-32 evaluated as MDR reversers, through rhodamine-123 accumulation assay flow cytometry chemosensitivity assays, resistant human...
Aiming to find Amaryllidaceae alkaloids against breast cancer, including the highly aggressive triple-negative phytochemical study of Pancratium maritimum was carried out. Several Amaryllidaceae-type alkaloids, bearing scaffolds haemanthamine-, homolycorine-, lycorine-, galanthamine-, and tazettine-type were isolated (3-11), along with one alkamide (2) a phenolic compound (1). The antiproliferative effect compounds (1-11) evaluated by sulforhodamine B assay cancer cell lines MDA-MB-231...
Cleistochlamys kirkii (Benth) Oliv. (Annonaceae) is a medicinal plant traditionally used in Mozambique to treat infectious diseases. The aim of this study was find resistance modifiers C. for Gram-positive and Gram-negative model bacterial strains. One the most important mechanisms bacteria efflux pump-related multidrug resistance. Therefore, polycarpol (1), three C-benzylated flavanones (2-4), acetylmelodorinol (5) were evaluated their resistance-reverting activity on...
Multidrug resistance is the major obstacle to cancer chemotherapy. Modulation of P-glycoprotein and drug combination approaches have been considered important strategies overcome resistance.
Aiming to find new antibacterial compounds from African medicinal plants, forty extracts of different polarity eight plant species were screened against Gram positive and negative bacteria. The selected Cleistochlamys kirkii, Colophospermum mopane, Cladostemon Chrysophyllum viridifolium, Gardenia ternifolia, Grewia hexamita, Xeroderris stuhlmannii Albizia adianthifolia, are used in Mozambique traditional medicine treat infectious diseases. best results obtained for both apolar polar C....
The main aim of this work was to find new antibacterial compounds from the African medicinal plant Cleistochlamys kirkii (Annonaceae) that is used in traditional medicine for treatment infectious diseases [1,2]. To achieve goal, root bark by native populations collected and a bioassay-guided phytochemical study performed on methanol extract. From dichloromethane soluble fraction extract several were isolated, namely C-benzylated flavanones, dioxopiperazine alkaloid, α,β-unsaturated lactones...