A5101633903- Acute Myeloid Leukemia Research
- Autophagy in Disease and Therapy
- Pharmacological Effects and Toxicity Studies
- Erythropoietin and Anemia Treatment
- Cytokine Signaling Pathways and Interactions
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immune Cell Function and Interaction
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Adolescent and Pediatric Healthcare
- RNA Research and Splicing
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Gut microbiota and health
- Diet and metabolism studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Colorectal Cancer Screening and Detection
- Blood disorders and treatments
- Child and Adolescent Health
- Erythrocyte Function and Pathophysiology
- Gastric Cancer Management and Outcomes
- Bone health and treatments
- Adipose Tissue and Metabolism
- Kruppel-like factors research
Rutgers Cancer Institute of New Jersey
2021-2025
Ludwig Cancer Research
2025
Rutgers, The State University of New Jersey
2021-2025
Princeton University
2025
Lebanese American University
2024
Tel Aviv University
2019-2021
St Thomas' Hospital
2020
Massachusetts Institute of Technology
2018
Harvard–MIT Division of Health Sciences and Technology
2018
King's College Hospital NHS Foundation Trust
2016
Amino acid starvation by the chemotherapy agent asparaginase is a potent activator of integrated stress response (ISR) in liver and can upregulate autophagy some cell types. We hypothesized that related 7 (ATG7), protein essential for an ISR target gene, was necessary during exposure to maintain health. knocked down Atg7 systemically (Atg7Δ/Δ) or hepatocytes only (ls-Atg7KO) mice before pegylated 5 d. Intact injected with lost body weight due reduced food intake increased energy expenditure....
Significance Prostate cancer is the most common noncutaneous in men, but there a need for better biomarkers that can identify aggressive disease. Here, we describe bottom-up approach to design nanosensors detect and classify prostate cancer. We used transcriptomic proteomic analysis proteolytic enzymes are dysregulated human built library of measure their activity vivo using multiplexed urinary readouts. In mouse models, demonstrated these could outperform serum biomarker. This be deployed...
Immune checkpoint blockade (ICB) has transformed cancer treatment, but success rates remain low in most cancers. Recent research suggest that dietary fiber enhances ICB response melanoma patients and murine preclinical models through microbiome-dependent mechanisms. Yet, the robustness of this effect across types contexts remains unclear. Specifically, prior literature compared grain-based chow (high fiber) to low-fiber purified diet, these diets differ also on other dimensions including...
The two erythropoietin (EPO) receptor forms mediate different cellular responses to erythropoietin. While hematopoiesis is mediated via the homodimeric EPO (EPOR), tissue protection conferred a heteromer composed of EPOR and CD131. In skeletal system, stimulates osteoclast precursors induces bone loss. However, underlying molecular mechanisms are still elusive. Here, we evaluated role heteromeric complex in metabolism vivo vitro by using Cibinetide (CIB), non-erythropoietic analogue that...
Introduction: Enhanced understanding of the pathogenesis Myeloproliferative Neoplasms (MPN) has led to rapid introduction novel therapeutic agents into clinical practice. Knowledge genetic landscape (eg. JAK2, MPL and CALR as commonly mutated genes) is increasing been used model novel, effective therapies. Histone Deacetylases (HDAC) are heavily involved in epigenetic modulation; their aberrant expression demonstrated, both vitro vivo, various MPN. A number HDAC inhibitors (HDACi) have since...
Patients 1 and 3 had relapse of their myeloma at 48 29 months post ASCT respecti CONCLUSION METHODS TD -thalidomide/dexamethasone PAD -bortezomib/doxorubicin/dexamethasone CVTD -cyclophosphamide/bortezomib/thalidomide CTD -cyclophosphamide/thalidomide/dexamethasone HDMhigh dose melphalan ABBREVIATIONS