A5081919090- Cannabis and Cannabinoid Research
- Neuroscience and Neuropharmacology Research
- X-ray Diffraction in Crystallography
- Organoboron and organosilicon chemistry
- GABA and Rice Research
- Neurotransmitter Receptor Influence on Behavior
- Synthesis and characterization of novel inorganic/organometallic compounds
- Fluorine in Organic Chemistry
- Crystallization and Solubility Studies
- Pharmacological Receptor Mechanisms and Effects
Leibniz-Forschungsinstitut für Molekulare Pharmakologie
2024
University of Freiburg
2021
Already 1 mol% of subvalent [Ga(PhF)2]+[pf]- ([pf]- = [Al(ORF)4]-, RF C(CF3)3) initiates the hydrosilylation olefinic double bonds under mild conditions. Reactions with HSiMe3 and HSiEt3 as substrates efficiently yield anti-Markovnikov anti-addition products, while bulkier such HSiiPr3 are less reactive. Investigating underlying mechanism by gas chromatography STEM analysis, we unexpectedly found that H2 metallic Ga0 formed. Without addition olefins, formation R3Si-F-Al(ORF)3 (R alkyl), a...
The diversity of physiological roles the endocannabinoid system has turned it into an attractive yet elusive therapeutic target. However, chemical probes with various functionalities could pave way for a better understanding at cellular level. Notably, inverse agonists CB2R – key receptor - lagged behind despite evidence regarding potential its antagonism. Herein, we report matched fluorescent probe pair based on common chemotype to address and visualize both active inactive states CB2R,...
The diversity of physiological roles the endocannabinoid system has turned it into an attractive yet elusive therapeutic target. However, chemical probes with various functionalities could pave way for a better understanding at cellular level. Notably, inverse agonists CB