A5080791645- Lipid Membrane Structure and Behavior
- Advanced Graph Neural Networks
- Ocular Surface and Contact Lens
- Protein purification and stability
- Complex Network Analysis Techniques
- Cellular transport and secretion
- Protein Kinase Regulation and GTPase Signaling
- Sphingolipid Metabolism and Signaling
- Protein Structure and Dynamics
- Inhalation and Respiratory Drug Delivery
- Viral Infectious Diseases and Gene Expression in Insects
- Surfactants and Colloidal Systems
- Glycosylation and Glycoproteins Research
- Supramolecular Self-Assembly in Materials
- Drug Solubulity and Delivery Systems
- Data Stream Mining Techniques
- Spectroscopy and Quantum Chemical Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- HIV Research and Treatment
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- Autophagy in Disease and Therapy
- Safe Handling of Antineoplastic Drugs
- Animal Diversity and Health Studies
- Nanopore and Nanochannel Transport Studies
Babasaheb Bhimrao Ambedkar University
2024
TU Dortmund University
2016-2020
Boehringer Ingelheim (Germany)
2018-2020
University of Münster
2014-2019
Broad-spectrum antivirals are powerful weapons against dangerous viruses where no specific therapy exists, as in the case of ongoing SARS-CoV-2 pandemic. We discovered that a lysine- and arginine-specific supramolecular ligand (CLR01) destroys enveloped viruses, including HIV, Ebola, Zika virus, remodels amyloid fibrils semen promote viral infection. Yet, it is unknown how CLR01 exerts these two distinct therapeutic activities. Here, we delineate novel mechanism antiviral activity by...
An hydroxylamine probe combined with mass spectrometry analysis enable accurate identification of fatty acids in <italic>S</italic>-acylated proteins.
Abstract Membrane‐bound c‐Src non‐receptor tyrosine kinase, unlike other acyl‐modified lipid‐anchored proteins, anchors to the membrane by a myristoyl chain along with polybasic residue stretch, which is shorter in length than its host membrane. The packing defect arising from this mismatched of and lipid anchor significantly affects lateral organization heterogeneous membranes. We reveal mixing phase domains formation novel nanoscale‐clusters upon binding Myr‐Src (2–9) peptide. Fluorescence...
Artificial lipid membranes play a growing role in technical applications such as biosensors pharmacological research and model systems the investigation of biological films. In standard procedure for displaying distribution membrane components, fluorescence microscopy, fluorophores used can influence components usually not all substances be displayed at same time. The discriminant analysis-based algorithm combination with scanning time-of-flight secondary ion mass spectrometry (ToF-SIMS)...
Signaling of N-Ras and K-Ras4B proteins depends strongly on their correct localization in the cell membrane. In vivo studies suggest that intermolecular interactions foster self-association both formation nanoclusters As sites for effector binding, nanocluster is thought to be essential effective signal transmission K-Ras4B. To shed more light spatial arrangement mechanism underlying proposed cross-talk between spatially segregated Ras proteins, simultaneous effect lateral organization a...
Abstract Membrane‐bound c‐Src non‐receptor tyrosine kinase, unlike other acyl‐modified lipid‐anchored proteins, anchors to the membrane by a myristoyl chain along with polybasic residue stretch, which is shorter in length than its host membrane. The packing defect arising from this mismatched of and lipid anchor significantly affects lateral organization heterogeneous membranes. We reveal mixing phase domains formation novel nanoscale‐clusters upon binding Myr‐Src (2–9) peptide. Fluorescence...
A multitude of outbreak prediction models are employed on a global scale to facilitate informed decision-making and the implementation appropriate control measures in light COVID-19 pandemic. The authorities now focusing straightforward epidemiological statistical methodology for forecasting epidemic. These widely recognized within media landscape. Long-term has been found have poor precision typical due presence considerable uncertainty insufficient vital data. Despite several efforts that...
Abstract Plasma membrane localization of myristoylated c‐Src, a proto‐oncogene protein‐tyrosine kinase, is required for its signaling activity. Recent studies proposed that UNC119 protein functions as solubilizing factor proteins, thereby regulating their subcellular distribution and signaling. The underlying molecular mechanism by which regulates the binding c‐Src has remained elusive. By combining different biophysical techniques, we have found c‐Src‐derived N‐terminal peptide (Myr‐Src)...