A5013323511- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Metabolism, Diabetes, and Cancer
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Protein Kinase Regulation and GTPase Signaling
- Caveolin-1 and cellular processes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Prostate Cancer Treatment and Research
- Endoplasmic Reticulum Stress and Disease
- Regulation of Appetite and Obesity
- Metabolomics and Mass Spectrometry Studies
- Lipid metabolism and biosynthesis
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- RNA regulation and disease
- MRI in cancer diagnosis
- T-cell and B-cell Immunology
- COVID-19 Impact on Reproduction
- Telomeres, Telomerase, and Senescence
- Birth, Development, and Health
National Heart Lung and Blood Institute
2014-2025
National Institutes of Health
2013-2025
Sun Yat-sen University
2023-2024
First Affiliated Hospital of Bengbu Medical College
2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Weatherford College
2020
Zhuhai People's Hospital
2020
The Second Affiliated Hospital of Bengbu Medical College
2019
University of Oslo
2014
Background: Palmitoleic acid (cis-16:1n-7), which is produced by endogenous fat synthesis, has been linked to both beneficial and deleterious metabolic effects, potentially confounded diverse determinants tissue sources of production. Trans-palmitoleate (trans-16:1n-7) represents a distinctly exogenous source 16:1n-7, unconfounded synthesis or its determinants, that may be uniquely informative. Objective: To investigate whether circulating trans-palmitoleate independently related lower risk...
Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose to systemic metabolic consequences are not fully understood. In study, we have taken advantage highly restricted coexpression adipocyte/macrophage fatty acid–binding proteins (FABPs) aP2 (FABP4) mal1 (FABP5) examine contribution these lipid chaperones in macrophages adipocytes local homeostasis mice. Deletion FABPs resulted reduced expression cytokines...
Caveolin-1 is a substrate for nonreceptor tyrosine kinases including Src, Fyn, and Abl. To investigate the function of caveolin-1 phosphorylation, we modified Gal4-based yeast two-hybrid system to screen phosphorylation-dependent protein interactions. A cDNA library was screened using N terminus as bait in strain expressing catalytic domain We identified two proteins this that interact with manner: tumor necrosis factor-α receptor-associated factor 2 (TRAF2) C-terminal Src kinase (Csk)....
Adipocyte fatty acid binding protein 4, aP2, contributes to the pathogenesis of several common diseases including type 2 diabetes, atherosclerosis, liver disease, asthma, and cancer. Although biological functions aP2 have classically been attributed its intracellular action, recent studies demonstrated that acts as an adipokine regulate systemic metabolism. However, mechanism regulation secretion remain unknown. Here, we demonstrate a specific role for lipase activity in from adipocytes...
Abstract Unlike protein-coding genes, the majority of human long non-coding RNAs (lncRNAs) are considered non-conserved. Although lncRNAs have been shown to function in diverse pathophysiological processes mice, it remains largely unknown whether such vivo functions. Here, we describe an integrated pipeline define non-conserved lncRNAs. We first identify with high potential using multiple indicators derived from genetic data related cardiometabolic traits, then lncRNA’s and specific target...
Glucose levels in mammals are tightly controlled through multiple mechanisms to meet systemic energy demands. Downregulation of hepatic glucokinase (GCK) during fasting facilitates the transition liver from a glucose-consuming gluconeogenic organ. Here, we report transcriptional regulation GCK by long non-coding RNA (lncRNA) named repressor (lncLGR). lncLGR is induced fasting, and physiological overexpression mimic effectively suppresses expression reduces glycogen content mice....
Abstract Long non-coding RNA Knowledgebase (lncRNAKB) is an integrated resource for exploring lncRNA biology in the context of tissue-specificity and disease association. A systematic integration annotations from six independent databases resulted 77,199 human (224,286 transcripts). The user-friendly knowledgebase covers a comprehensive breadth depth annotation. lncRNAKB compendium expression patterns, derived analysis RNA-seq data thousands samples across 31 solid normal tissues (GTEx)....
Fatty acid-binding proteins (FABPs) are cytosolic fatty acid chaperones that play a critical role in systemic regulation of lipid and glucose metabolism. In animals lacking the adipocyte/macrophage FABP isoforms aP2 mal1, there is strong protection against diet-induced obesity, insulin resistance, type 2 diabetes, liver disease, hypercholesterolemic atherosclerosis. On high-fat diet, FABP-deficient mice also exhibit enhanced muscle AMP-activated kinase (AMPK) reduced stearoyl-CoA...
Large intergenic noncoding RNAs (lincRNAs) have been recognized in recent years to constitute a significant portion of the mammalian transcriptome, yet their biological functions remain largely elusive. This is partly due an incomplete annotation tissue-specific lincRNAs essential model organisms, particularly mice, which has hindered genetic and functional characterization these novel transcripts. In this report, we performed ab initio assembly 1.9 billion RNA-sequencing reads across six...
Caveolin-1 is phosphorylated on Tyr14 in response to both oxidative and hyperosmotic stress. In the present paper, we show that this phosphorylation requires activation of Src family kinase Fyn. Stress-induced caveolin was abolished by three inhibitors, SU6656, PP2 PD180970, not observed fibroblasts derived from a Src, Yes Fyn triple-knockout mouse (SYF−/−). Using cell lines single-kinase-knockout mice (Src−/−, Yes−/− Fyn−/−), expression Fyn, but or Yes, required for stress-induced...
A growing number of long noncoding RNAs (lncRNAs) have emerged as vital metabolic regulators. However, most human lncRNAs are nonconserved and highly tissue specific, vastly limiting our ability to identify lncRNA regulators (hLMRs). In this study, we established a pipeline putative hLMRs that metabolically sensitive, disease relevant, population applicable. We first progressively processed multilevel transcriptome data select liver exhibit dynamic expression in the general population, show...
Obesity and type 2 diabetes mellitus are global emergencies long noncoding RNAs (lncRNAs) regulatory transcripts with elusive functions in metabolism. Here we show that a high fraction of lncRNAs, but not protein-coding mRNAs, repressed during diet-induced obesity (DIO) refeeding, whilst nutrient deprivation induced lncRNAs mouse liver. Similarly, lost diabetic humans. LncRNA promoter analyses, cistrome gain-of-function analyses confirm increased MAFG signaling DIO curbs lncRNA expression....
Mouse is the most widely used animal model in biomedical research, but it remains unknown what causes large number of differentially regulated genes between human and mouse livers identified recent years. In this report, we aim to determine whether these divergent gene regulations are primarily caused by environmental factors or some them result cell-autonomous differences regulation liver cells. The latter scenario would suggest that many subject human-specific can only be adequately...