A5101541679- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Anesthesia and Sedative Agents
- Memory and Neural Mechanisms
- Anesthesia and Pain Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural Networks and Reservoir Computing
- Veterinary Pharmacology and Anesthesia
- Immune cells in cancer
- Functional Brain Connectivity Studies
- Neural Networks and Applications
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Nausea and vomiting management
- Autophagy in Disease and Therapy
- Neuroscience and Neural Engineering
University of Freiburg
2017-2024
Brain (Germany)
2024
Ernst Strüngmann Institute for Neuroscience
2017
Goethe University Frankfurt
2014
Current neural decoding methods typically aim at explaining behavior based on activity via supervised learning. However, since generally there is a strong connection between learning of subjects and their expectations long-term rewards, we propose NeuRL, an inverse reinforcement approach that (1) extracts intrinsic reward function from collected trajectories subject in closed form, (2) maps signals to this account for dependencies the (3) predicts simulated unseen by extracting Q-values...
Simultaneous recordings and manipulations of neural circuits that control the behavior animals is one key techniques in modern neuroscience. Rapid advances optogenetics have led to a variety probes combining multichannel readout optogenetic write in. Given complexity brain, it comes as no surprise choice device constrained by several factors such animal model, structure location brain area interest, well behavioral read out. Here we provide an overview available devices for chronic...
Effective pain management in laboratory animals is crucial for both animal welfare and the reliability of scientific research. We retrospectively examined effects carprofen as post-operative analgesia Sprague Dawley rats following stereotactic surgery. Our data indicate that administering twice daily (5 mg/kg), currently recommended by GV-SOLAS, led to adverse such reduced food water intake, disrupted fecal excretion, abdominal bloating consistent with peritonitis. Continued administration...
Goal-directed action control and behavioral flexibility are prerequisites for effective, adaptive behavior. Both abilities rely on functional motor inhibition, which is linked to the prefrontal cortex (PFC), where distinct subsections collaborate in networks. How these PFC interact roles they play during inhibition remains incompletely understood. In this study, we employed an action-preparation task rats, combined with bidirectional optogenetic interventions, opto-fMRI, single unit...
Effective pain management in laboratory animals is crucial for both animal welfare and the reliability of scientific research. We retrospectively examined effects carprofen as post-operative analgesia Sprague Dawley rats following stereotactic surgery. Our data indicate that administering twice daily (5 mg/kg), currently recommended by
In everyday life altering environmental conditions require flexible adaptation of planned or already initiated actions. Humans and animals are forced to constantly update their behavior avoid maladaptive Studies linked responseinhibition deficits several neurological diseases emphasized the critical role PFC for appropriately timed actions (Aron, 2011; Aron et al., 2014a; Chambers 2009). These neuropsychiatric disorders include fronto-temporal dementia (Pompanin 2014), Parkinson’s disease...