A5111560986- Microbial Natural Products and Biosynthesis
- High Entropy Alloys Studies
- Fungal Biology and Applications
- Natural product bioactivities and synthesis
- High-Temperature Coating Behaviors
- High Temperature Alloys and Creep
- Heat Transfer and Optimization
- Phytochemistry and Biological Activities
- Vibration and Dynamic Analysis
- Cellular Mechanics and Interactions
- Plant-derived Lignans Synthesis and Bioactivity
- Chemical synthesis and alkaloids
- Cavitation Phenomena in Pumps
- Shape Memory Alloy Transformations
- Fluid Dynamics Simulations and Interactions
- Heat Transfer and Boiling Studies
- Recycling and Waste Management Techniques
- Phytochemical compounds biological activities
- Phytochemistry and Bioactive Compounds
- Fungal Plant Pathogen Control
- Phytochemicals and Antioxidant Activities
- Sustainable Supply Chain Management
- Electrospun Nanofibers in Biomedical Applications
- Additive Manufacturing Materials and Processes
- Extraction and Separation Processes
Xi'an Jiaotong University
2018-2024
Weatherford College
2024
Shanghai Jiao Tong University
2013-2021
Yangtze University
2020
Nanjing University of Aeronautics and Astronautics
2002-2019
Institute of Microbiology
2016-2017
Chinese Academy of Sciences
2008-2017
China Agricultural University
2013-2016
State Key Laboratory of Plant Genomics
2016
Institute of Genetics and Developmental Biology
2016
Ustilaginoidins were bis-naphtho-γ-pyrones mycotoxins possessing an aR configuration of the chiral axis previously reported from false smut balls rice infected by fungal pathogen Ustilaginoidea virens. To investigate chemical diversity these metabolites and their bioactivities, we fermented this fungus on solid media, which afforded isolation 13 ustilaginoidins, including seven new compounds, namely ustilaginoidins K–P, 1–6, E1, 7, together with known A, 8, D, 9, E, 10, F, 11, G, 12,...
Abstract Injury to the central nervous system (CNS) usually leads activation of astrocytes, followed by glial scar formation. The formation scars from active astrocytes in vivo has been found be dependent on cell microenvironment. However, how respond different microenvironmental cues during formation, such as changes matrix stiffness, remains elusive. In this work, we established an vitro model assess responses stiffness that may related pathophysiology. investigated hydrogel backbones are...
Nine new spirobisnaphthalenes, palmarumycins B1-B9 (1-9), along with 13 known compounds (10-22), were isolated from cultures of the fungus Berkleasmium sp., an endophyte medicinal plant Dioscorea zingiberensis C. H. Wright. The structures elucidated by analysis 1D and 2D NMR HRESIMS spectra comparison compounds. Compounds 7-9 contain uncommon 2,3-dihydro-1H-inden-1-one unit. All evaluated for their antibacterial activities against Bacillus subtilis, Staphylococcus hemolyticus, Agrobacterium...
Six new dibenzo-α-pyrones, rhizopycnolides A (1) and B (2) rhizopycnins A–D (3–6), together with eight known congeners (7–14), were isolated from the endophytic fungus Rhizopycnis vagum Nitaf22 obtained Nicotiana tabacum. The structures of compounds unambiguously elucidated using NMR, HRESIMS, TDDFT ECD calculation, X-ray crystallography data. Rhizopycnolides feature an uncommon γ-butyrolactone-fused dibenzo-α-pyrone tetracyclic skeleton (6/6/6/5), while rhizopycnin (4) was first amino group...
The EtOAc extract of the liquid fermentation Alternaria sp. Samif01, an endophytic fungus obtained from Salvia miltiorrhiza Bunge, showed antibacterial activity against several tested bacterial pathogens. Fractionation this led to isolation seven dibenzo-α-pyrones (1–7), including one new compound, 2-acetoxy-2-epi-altenuene (1) and natural product, 3-epi-dihydroaltenuene A (2). structures metabolites were elucidated by comprehensive analysis spectroscopic data (1D, 2D) NMR HRESIMS, while...
Chemical examination of the exuded gum resin Boswellia carterii resulted in isolation nine new prenylaromadendrane-type diterpenes, boscartols A-I (1-9). The structures these compounds were established by extensive 1D and 2D NMR spectroscopic analyses, mass spectrometric data, circular dichroism spectra. Compounds 1-3, 5, 6, 8, 9 (10 μM) showed moderate hepatoprotective activity against d-galactosamine-induced HL-7702 cell damage.
Two spirobisnaphthalenes, namely palmarumycins C2 and C3, were isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. After addition 1-hexadecene at 10% to medium on day 6 culture, maximal yields C3 obtained as 0.40 g/L 1.19 g/L, which 40.00 fold 59.50 higher, respectively, in comparison those control (0.01 0.02 g/L). The results indicated that can be an effective strategy for enhancing production liquid culture Dzf12. Palmarumycin exhibited...
Three new sesquiterpenes (1-3) and two rutinosides (4 5) along with 17 known compounds (6-22) were isolated from the leaves of Murraya koenigii (L.) Spreng. The elucidated as (3R,5S,6R)-3,5,6-trihydroxy-1,1,5-trimethylcyclohexyl-8-butyn-9-one (1), (8E,9R)-ethyl-7-(3S,5R,6S)-3,6-dihydroxy-1,1,5-trimethylcyclohexyl-9-hydroxybut-8-enoate (2), (3R)-3-O-β-D-glucoside-6'-D-apiose-β-ionone (3), 4-O-β-D-rutinosyl-3-methoxyphenyl-1-propanone (4), 1-O-β-D-rutinosyl-2(R)-ethyl-1-pentanol (5) based on...
Background: Kiwi root is a Chinese herb clinically used in the treatment of lung neoplasm; however, multi-target mechanism kiwi non-small cell cancer (NSCLC) remains to be elucidated. Thus, this study aimed investigate molecular mechanisms NSCLC through network pharmacology and docking techniques. Methods: The active components targets were obtained from TCMSP database, NSCLC-related GeneCards, OMIM, DrugBank databases. intersection VENNY 2.1.0. Then, common imported into STRING by using...
Abstract Natural extracellular matrix (ECM) mostly has a fibrous structure that supports and mechanically interacts with local residing cells to guide their behaviors. The effect of ECM elasticity on cell behaviors been extensively investigated, while less attention paid the fiber‐network plasticity at microscale, although plastic remodeling is common phenomenon in fibrosis. Here, significant decrease found native fibrotic tissues, which associated an increase crosslinking. To explore role...