A5014119597- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Eicosanoids and Hypertension Pharmacology
- Healthcare Operations and Scheduling Optimization
- Health Systems, Economic Evaluations, Quality of Life
- Hormonal Regulation and Hypertension
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Clinical practice guidelines implementation
- Estrogen and related hormone effects
- Steroid Chemistry and Biochemistry
- Adipose Tissue and Metabolism
- Inflammatory mediators and NSAID effects
- Ion channel regulation and function
- Aquaculture disease management and microbiota
- Cardiovascular Health and Risk Factors
- Neuropeptides and Animal Physiology
- Regulation of Appetite and Obesity
- Receptor Mechanisms and Signaling
- Acute Kidney Injury Research
- Muscle metabolism and nutrition
Heinrich Heine University Düsseldorf
2013-2024
Ottawa Hospital
2021-2022
Institute of Pharmacology
2016
Düsseldorf University Hospital
2013-2016
DuPont (United States)
1993-1994
Wilmington University
1993-1994
Experimental Station
1993
Selective inhibition of the inducible isoform prostaglandin G/H synthase (cyclooxygenase-2; COX2; EC 1.14.99.1) can be achieved with compounds general form aryl methyl sulfonyls and sulfonamides. DuP 697 NS-398 are representative examples these compounds. Both inhibit constitute (COX1) (COX2) isoforms enzyme equal potency shortly after mixing, but their potencies increase time for COX2 selectively. This time-dependent follows first-order kinetics, rate constant inactivation is dose dependent...
Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding complex network food intake energy balance regulation an essential prerequisite for pharmacological intervention obesity. G protein-coupled receptors (GPCRs) are among main modulators metabolism balance. They, instance, regulate appetite satiety in certain hypothalamic neurons, as well glucose lipid hormone secretion from adipocytes. Mutations some GPCRs, such...
Vascular oxidative stress generated by endothelial NO synthase (eNOS) was observed in experimental and clinical cardiovascular disease, but its relative importance for vascular pathologies is unclear. We investigated the impact of eNOS-dependent on function neointimal hyperplasia.
The most common trigger of sepsis and septic shock is bacterial lipopolysaccharide (LPS). Endothelial cells are among the first to encounter LPS directly. Generally, their function closely linked active endothelial NO Synthase (eNOS), which significantly reduced under conditions. treatment leads activation apoptosis, resulting in loss integrity vascular leakage, a hallmark shock. Hence, therapies that prevent leakage or restore barrier would be invaluable for patients. Adhesion GPCRs...
Objectives: Endothelial dysfunction and oxidative stress are associated with hypertension but whether endothelial superoxide may play a role in the early development of essential remains uncertain. We investigated nitric oxide synthase (eNOS)-derived is involved regulation SBP. Methods: Wild-type eNOS [mice endothelium-specific overexpression bovine NO-synthase (eNOS-Tg)] or novel dimer-destabilized eNOS-mutant harboring partially disrupted zinc-finger destabilized by replacement Cys 101 to...
The carrageenan pleurisy model, which is characterized by cellular influx and oedema, has been used to examine the effects of anti‐inflammatory compounds such as naproxen. Interleukin‐1α β (IL‐1) are known be pro‐inflammatory mediators, their roles in this model unknown. Intrapleural injection 1% viscarin or saline was administered male Lewis rats. Four 24 h later, cell counts, fluid volumes IL‐1β levels (measured ELISA) were determined pleural cavity. Serum corticosterone measured only at 4...
Abstract: Ambulatory cancer centers face fluctuating patient demand and deploy specialized personnel who have variable availability. This undermines operational stability through misa-lignment of resources to needs, resulting in overscheduled clinics, budget deficits, wait times exceeding provincial targets. We describe deployment a Learning Health System framework for improvements within the entire ambulatory center. Known methods value stream mapping, operations research statistical...
Ambulatory cancer centers face fluctuating patient demand and deploy specialized personnel who have variable availability. This undermines operational stability through misalignment of re-sources to needs, resulting in overscheduled clinics, high rebooking rates, budget deficits, wait times exceeding provincial targets. We describe how deploying a Learning Health System framework led improvements within the entire ambulatory center. Known methods value stream mapping, operations research...
Purpose: Despite irrefutable role of endothelial nitric oxide synthase (eNOS) in vascular smooth muscle tone, its contribution to the regulation blood pressure has been proven mainly either by global eNOS-deficiency or use unspecific NOS-inhibitors. To distinguish relevance and non-endothelial eNOS, we generated a novel double transgenic mouse model lacking eNOS all organs except endothelium. The aim study was evaluate (BP).
Endothelial dysfunction and oxidative stress are associated with hypertension but whether endothelial superoxide plays a role in the early development of essential remains uncertain. We investigated eNOS-derived is involved regulation blood pressure. Wild-type eNOS (eNOS-Tg) or novel dimer-destabilized eNOS-mutant harboring partially disrupted zinc-finger (C101A-eNOS-Tg) was introduced C57BL/6 an endothelial-specific manner. C101A-eNOS-Tg showed significantly increased generation, protein-...
Endothelial dysfunction and oxidative stress are associated with hypertension but whether endothelial superoxide plays a role in the early development of essential remains uncertain. In this study we investigated eNOS-derived is involved regulation blood pressure (BP). Normal bovine eNOS (eNOS-Tg) or novel dimer-destabilized eNOS-mutant harboring partially disrupted zinc-finger (C101A-eNOS-Tg) was introduced C57BL/6 mice using endothelium-specific tie-2 promoter. Mice were monitored for...
Purpose: Essential hypertension is associated with endothelial dysfunction. However, if dysfunction contributes to the pathophysiology of essential remains unclear. Methods: Wildtype eNOS (eNOS-tg) or a destabilized (C101A-eNOS-tg) were introduced into endothelium C57BL/6 mice using specific tie-2 promoter. Destabilization was induced via replacement cysteine by alanine. Transfection in HEK cells demonstrated decreased dimer stability and NO formation increased superoxide (O2-) generation....
Ambulatory cancer centers face a fluctuating patient demand and deploy specialized personnel who have variable availability. This undermines operational stability through the misalignment of resources to needs, resulting in overscheduled clinics, budget deficits, wait times exceeding provincial targets. We describe deployment Learning Health System framework for improvements within entire ambulatory center. Known methods value stream mapping, operations research statistical process control...