A5077886439- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- SARS-CoV-2 detection and testing
- Microfluidic and Bio-sensing Technologies
- Mechanical and Optical Resonators
- Force Microscopy Techniques and Applications
- Extracellular vesicles in disease
- Electrochemical sensors and biosensors
- Nanopore and Nanochannel Transport Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Respiratory viral infections research
- Advanced MEMS and NEMS Technologies
- Analytical Chemistry and Sensors
- Microfluidic and Capillary Electrophoresis Applications
- Analytical chemistry methods development
- 3D Printing in Biomedical Research
- Lipid Membrane Structure and Behavior
- Cellular Mechanics and Interactions
- Composite Structure Analysis and Optimization
- Advanced Chemical Sensor Technologies
- Thermal properties of materials
- Spectroscopy Techniques in Biomedical and Chemical Research
- Plasmonic and Surface Plasmon Research
- Gas Sensing Nanomaterials and Sensors
- Anodic Oxide Films and Nanostructures
McGill University
2020-2024
University of Tehran
2016-2021
Extracellular vesicles (EVs) are continually released from cancer cells into biofluids, carrying actionable molecular fingerprints of the underlying disease with considerable diagnostic and therapeutic potential. The scarcity, heterogeneity intrinsic complexity tumor EVs present a major technological challenge in real-time monitoring complex cancers such as glioblastoma (GBM). Surface-enhanced Raman spectroscopy (SERS) outputs label-free spectroscopic fingerprint for EV profiling. However,...
A nanosurface microfluidic platform based on suspended plasmonic nanobowties for surface-enhanced Raman spectroscopy (SERS) of Glioblastoma extracellular vesicles.
Abstract The last pandemic exposed critical gaps in monitoring and mitigating the spread of viral respiratory infections at point‐of‐need. A cost‐effective multiplexed fluidic device (NFluidEX), as a home‐test kit analogous to glucometer, that uses saliva blood for parallel quantitative detection infection body's immune response an automated manner within 11 min is proposed. technology integrates versatile biomimetic receptor based on molecularly imprinted polymers core–shell structure with...
Multimeric aptamers have gained more attention than their monomeric counterparts due to providing binding sites for target analytes, leading increased affinity. This work attempted engineer the surface-based generation of multimeric by employing room temperature rolling circle amplification (RCA) technique and chemically modified primers developing a highly sensitive selective electrochemical aptasensor. The aptamers, generated through surface RCA, are hybridized spacer primers, facilitating...
Here, we report on an electrochemical biosensor based core–shell structure of gold nano/micro-islands (NMIs) and electropolymerized imprinted ortho-phenylenediamine (o-PD) for detection heart-fatty acid binding protein (H-FABP). The shape distribution NMIs (the core) were tuned by controlled electrodeposition a thin layer electrochemically reduced graphene oxide (ERGO). feature large active surface area to achieve low limit (2.29 fg mL–1, sensitivity 1.34 × 1013 μA mM–1) wide linear range (1...
A nanostructured microfluidic device, featuring a series of self-organized gold nanocavities, enhanced with graphene nanosheets, for ultrasensitive, quantitative, and plasmon-assisted electrochemical detection H 2 O released from cancer cells.
Wearable sweat monitoring represents an attractive opportunity for personalized healthcare and evaluating sports performance. One of the limitations with such monitoring, however, is water layer formation upon cycling ion-selective sensors, leading to degraded sensitivity long-term instability. Our report first use chemical vapor deposition-grown, three-dimensional, graphene-based, gradient porous electrodes minimize formation. The proposed design reduces ion diffusion path within polymeric...
In this paper, an analysis of free vibration in functionally graded nanoplate is presented. Third-order shear deformation plate theory used to reach more accuracy results. Small-scale effects are investigated using Eringen`s nonlocal theory. The governing equations motion obtained by Hamilton`s principle. It assumed that the properties nanoplates vary through their thicknesses according a volume fraction power law distribution. finite element method (FEM) presented model and solve...
Abstract Cells mechanical property assessment has been a promising label-free method for cell differentiation. Several methods have proposed single-cell properties analysis. Dielectrophoresis (DEP) is one used assessment, separation, and sorting. DEP overcome weaknesses of other techniques, including compatibility with microfluidics, high throughput accuracy. However, due to the lack general explicit model this method, it not known as an ideal evaluation method. Here we present using most...
Extracellular vesicles (EVs) are cell-derived membrane structures that circulate in body fluids and show considerable potential for noninvasive diagnosis. EVs possess surface chemistries encapsulated molecular cargo reflect the physiological state of cells from which they originate, including presence disease. In order to fully harness diagnostic EVs, there is a critical need technologies can profile large EV populations without sacrificing single level detail by averaging over multiple EVs....
Abstract Multimeric aptamers have gained more attention than their monomeric counterparts due to providing binding sites for target analytes, leading increased affinity. This work attempted engineer the surface‐based generation of multimeric by employing room temperature rolling circle amplification (RCA) technique and chemically modified primers developing a highly sensitive selective electrochemical aptasensor. The aptamers, generated through surface RCA, are hybridized spacer primers,...
Additive manufacturing leveraged automated sample-answer microfluidic setup for colorimetric detection of pathogen.
A nanofluidic device with real-time confinement control to load digital nanocavities target nucleic acids, allowing exposure necessary enzymes/co-factors for amplification.
Bacteria have numerous large dsDNA molecules that freely interact within the cell, including multiple plasmids, primary and secondary chromosomes. The cell membrane maintains a micron-scale confinement, ensuring species are proximal at all times strongly in manner influenced by morphology (e.g. whether geometry is spherical or anisotropic). These interactions lead to non-uniform spatial organization complex dynamics, segregation of plasmid DNA polar regions. However, exactly how this arises,...
Background: With the assistance of Nano-technology, many devices have been proposed which are capable analyzing infinitesimal particles accurately. Objective: Nano-plates essential parts in Bio-Nano Electro Mechanical Systems (Bio-NEMS), such as Bio-sensors and Lap-on-Chips, systems working based on oscillations Nano-plates. Methods: In this paper, Third-order Shear Deformation Nanoplates actuated by an electrostatic force is modeled with nonlocal linear elasticity theory. Because high...
Abstract Colorimetric readout for the detection of infectious diseases is gaining traction at point care/need owing to its ease analysis and interpretation, integration potential with highly specific Loop-mediated amplification (LAMP) assays. However, coupling colorimetric LAMP rife challenges including, rapidity, inter-user variability, signal quantification, user involvement in sequential steps assay, hindering application. To address these challenges, first time, we propose a remotely...
Here we demonstrate nano-scale liposome templating using dielectrophoretic (DEP) force. When an AC electric field is applied between two parallel electrodes, the resulting DEP force will trap and physically confine targets, allowing for dynamic manipulation without need mechanical components or hydrodynamic Moreover, due to frequency dependence of effect, physical confinement adjustable can be reversed by tuning frequency. We believe that this approach useful single Extracellular Vesicle analysis.
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to develop, need for portable rapid testing platforms remains prevalent provide patients with accurate and quantitative diagnostic serosurveillance information at point-of-care. The current gold standard detection techniques like RT-PCR ELISA require trained personnel perform lengthy protocols, resulting in a long turnover from sample collection result acquisition. Herein, we propose an electrochemical microfluidic...
Abstract The authors have requested that this preprint be removed from Research Square.
With the continuously fluctuating incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), critical gaps in field rapid diagnostic testing have been exposed, particularly diagnosis viral infections. Current gold standard methods rely on real time quantitative polymerase chain reaction (RT-qPCR) for detection nucleic acids, but these tests are challenged with long turnaround times, costly centralized laboratory equipment and need trained personnel to execute protocols....
Plasmonic nanostructures are widely studied in opto-electrical sensing and biosensing. Despite their enhanced optical electromagnetic properties, the complexity of fabrication hinders integration into cost-effective scalable electrodes. Here, we focus on a fabless approach to develop hybrid structure gold (Au) plasmonic nanocavities graphene nanosheets for assisted electrochemical detection hydrogen peroxide (H <inf xmlns:mml="http://www.w3.org/1998/Math/MathML"...