A5100714378- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Scoliosis diagnosis and treatment
- Spondyloarthritis Studies and Treatments
- Spinal Fractures and Fixation Techniques
- TGF-β signaling in diseases
- Liver physiology and pathology
- Congenital Diaphragmatic Hernia Studies
- Peptidase Inhibition and Analysis
- T-cell and B-cell Immunology
- Connective tissue disorders research
- Genetic factors in colorectal cancer
- Pregnancy-related medical research
- Adipokines, Inflammation, and Metabolic Diseases
- Hip disorders and treatments
- Osteoarthritis Treatment and Mechanisms
- Adipose Tissue and Metabolism
- Medical Imaging and Analysis
- Autoimmune Bullous Skin Diseases
- Respiratory Support and Mechanisms
- Ubiquitin and proteasome pathways
Peking Union Medical College Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Nanjing Drum Tower Hospital
2023-2024
Second Affiliated Hospital of Nantong University
2022
Affiliated Hospital of Nantong University
2022
Nantong University
2022
Affiliated Zhongshan Hospital of Dalian University
2020
Abstract Intervertebral discs (IVDs) are rhythmic tissues that experience daily low‐load recovery. Notably, aging and abnormal mechanical stress predispose IVDs to degeneration due dysrhythmia‐induced disordered metabolism. Meanwhile, Rev‐erbα acts as a transcriptional repressor in maintaining biorhythms homeostasis; however, its function IVD homeostasis remains unclear. This study assessed the relationship between low expression levels degeneration. deficiency accelerated needle puncture or...
ABSTRACT Background Spondylocostal dysplasia (SCD) is characterized by vertebral defects and rib abnormalities. Following radiological diagnosis, further genetic testing conducted to confirm the mutant loci identify subtype of SCD. While seven potentially associated with SCD have been identified, rare cases remain unexplained. Case Presentations A 37‐year‐old female diagnosed at birth was reported in this study. She exhibited scoliosis thoracic asymmetry, along a left‐sided bilateral breast...
Abstract Facet joint osteoarthritis (FJOA) is a prevalent degenerative condition in the aging population; however, underlying pathophysiological mechanisms remain poorly understood and current therapeutic strategies limited to palliative pain management. In this study, novel potential targets prevention paradigms for FJOA are systematically explored. Proteomic screening validation show that Talin2 specifically upregulated samples. Immunoprecipitation‐mass spectrometry, transcriptome RNA...
Omentin-1 is a newly discovered metabolic regulatory adipokine. Studies have shown that omentin-1 possesses pleiotropic effects in different types of cells. This study aims to investigate the regulation by on mitochondrial biogenesis chondrocytes.C-28/I2 chondrocytes were treated with (150 and 300 ng/ml) for 24 h. The expression regulators, markers DNA copy was assessed. morphology observed electron microscopy. respiratory rate ATP production measured cell lysates.Omentin-1 treatment...
The aim of this study was to explore the correlation between PI and standing-to-sitting changes sagittal alignment in patients with lumbar degenerative diseases, investigate differences posture among Roussouly types. A total 209 disease were retrospectively included study. All received lateral full body imaging both standing sitting positions. Sagittal parameters including SVA, OD-HA, PT, PI, PT/PI, SS, LL, TK, Upper LL (L1-L4) Lower (L4-S1) measured position, compared two correlations...
OBJECTIVE The aim of this study was to investigate the effectiveness preoperative halo-gravity traction (HGT) with subsequent growing rod (GR) treatment in patients severe early-onset scoliosis (EOS). METHODS authors retrospectively reviewed a cohort EOS who had received HGT GR at their center between January 2008 and 2020. Patients Cobb angle coronal or sagittal plane that > 90° were included. All least 6 weeks before placement. Results pulmonary function tests (PFTs) blood gas compared...
Diffuse idiopathic skeletal hyperostosis (DISH) is characterized by osteophytes in the anterior vertebrae, and presence of aorta may have an impact on their formation. However, anatomical positional relationship between patients with DISH remains controversial. This study aimed to evaluate position relation DISH, influence aortic pulsation formation from perspective morphology.We conducted a retrospective review 101 diagnosed symptomatic lumbar spinal stenosis June 2018 December 2021. A...