A5103865127- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- Neuroscience and Neuropharmacology Research
- Nanoplatforms for cancer theranostics
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- Mitochondrial Function and Pathology
- Intensive Care Unit Cognitive Disorders
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- 3D Printing in Biomedical Research
- Nicotinic Acetylcholine Receptors Study
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cholinesterase and Neurodegenerative Diseases
- S100 Proteins and Annexins
- Retinal Development and Disorders
- Biosensors and Analytical Detection
- Neurological Disease Mechanisms and Treatments
- Telomeres, Telomerase, and Senescence
- Ginseng Biological Effects and Applications
Sichuan University
2018-2025
Tongji University
2023-2025
Shanghai Clinical Research Center
2025
First Affiliated Hospital of Sichuan Medical University
2025
Affiliated Hospital of Southwest Medical University
2025
Chengdu University of Traditional Chinese Medicine
2024
State Key Laboratory of Biotherapy
2024
Guiyang Medical University
2024
Affiliated Hospital of Guizhou Medical University
2024
Jilin University
2024
DNA nanorobots have emerged as new tools for nanomedicine with the potential to ameliorate delivery and anticancer efficacy of various drugs. nanostructures been considered one most promising nanocarriers. In present study, we report a framework-based intelligent nanorobot selective lysosomal degradation tumor-specific proteins on cancer cells. We site-specifically anchored an anti-HER2 aptamer (HApt) tetrahedral framework nucleic acid (tFNA). This (HApt-tFNA) could target HER2-positive...
Abstract Systemic immune monitoring is a crucial clinical tool for disease early diagnosis, prognosis and treatment planning by quantitative analysis of cells. However, conventional using flow cytometry faces huge challenges in large-scale sample testing, especially mass health screenings, because time-consuming, technical-sensitive high-cost features. the lack high-performance detection platforms hinders development high-throughput technology. To address this bottleneck, we constructed...
One of the biggest obstacles for use antisense oligonucleotides as antibacterial therapeutics is their limited uptake by bacterial cells without a suitable carrier, especially in multi-drug-resistant bacteria with drug efflux mechanism. Existing vectors, such cell-penetrating peptides, are inefficient and nontargeting, accordingly not ideal carriers. A noncytotoxic tetrahedral DNA nanostructure (TDN) controllable conformation has been developed delivery vehicle oligonucleotides. In this...
Stem cell-based therapy is considered a promising approach for the repair of nervous tissues. Neural stem cells (NSCs) cannot proliferate or differentiate efficiently; hence, different biomaterials have been explored to improve NSC proliferation and differentiation. However, these agents either had low bioavailability poor biocompatibility. In this work, our group investigated effects tetrahedral DNA nanostructures (TDNs), novel biological material, on self-renew differentiation...
Recently, a DNA tetrahedron has been reported to be novel nanomedicine and promising drug vector because of its compactness, biocompatibility, biosafety, editability. Here, we modified the with aptamer (AS1411) as DNA-based delivery system, which could bind nucleolin for cancer cell selectivity. Nucleolin is specific biomarker protein overexpressed on membranes malignant cells deregulation implicated in proliferation. The antimetabolite 5-fluorouracil (5-FU) an extensively used anticancer...
Genetic manipulations and pharmaceutical interventions to disturb lipid metabolism homeostasis have emerged as an attractive approach for the management of cancer. However, research on utilization bioactive materials modulate remains constrained. In this study, heptakis (2,3,6-tri-O-methyl)-β-cyclodextrin (TMCD) is utilized fabricate homomultivalent polymeric nanotraps, surprisingly, its unprecedented ability perturb induce pyroptosis in tumor cells found. Through modulation density TMCD...
Abstract Biofilm formation is responsible for numerous chronic infections and represents a serious health challenge. Bacteria the extracellular polysaccharides (EPS) cause biofilms to become adherent, toxic, resistant antibiotics, ultimately difficult remove. Inhibition of EPS synthesis can prevent bacterial biofilms, reduce their robustness, promote removal. Here, we have developed framework nucleic acid delivery system with tetrahedral configuration. It easily access cells functions by...
Spinal cord injury (SCI), began with a primary including contusion and compression, is common disease caused by various pathogenesis. Characterized disruption of axons irreversible loss neurons in SCI, further damage spinal tissue following secondary injuries, such as the formation glial scar inflammation, makes it even harder to recover for affected patients. Tetrahedral framework nucleic acid (tFNA), which possesses capability promoting neuroprotection neuroregeneration vitro, might...
With the incidence of different bone diseases increasing, effective therapies are needed that coordinate a combination various technologies and biological materials. Bone tissue engineering has also been considered as promising strategy to repair defects. Therefore, materials can promote stem cell proliferation, migration, osteoblastic differentiation accelerate regeneration have become focus research in multiple fields. Stem therapy, biomaterial scaffolds, growth factors shown potential for...
Abstract Objectives The main purpose of current study was to explore the effects tetrahedral DNA nanostructures (TDNs) on neuroectodermal ( NE ‐4C) stem cells migration and unveil potential mechanisms. Materials methods successfully self‐assembled TDN s were also determined by dynamic light scattering DLS ). A bidirectional wound‐healing assay transwell chamber employed test migrating behaviour ‐4C cultured under different conditions. Results Through an in vitro study, we found that could...
The human mitochondrial ATP-dependent Lon protease functions in regulating the metabolism and quality control of proteins DNA (mtDNA). However, role cancer is not well understood. Therefore, this study was undertaken to investigate importance cervical cells from patients established cell lines. Microarray analysis 30 10 normal tissues were analyzed by immunohistochemistry for protein levels. expression also examined immunoblotting 16 fresh their respective non-tumor tissues. In all cases,...
Senescent cells are characterized by their resistance to apoptosis, and upon long-term survival senescent affect tissue function eventually become deleterious the organism. Thus, far, it has been gradually accepted that clearance of these could reduce dysfunction. This study aimed investigate biological effects tetrahedral DNA nanostructures (TDNs) on cells. The results revealed a different effect TDNs, TDNs can induce phenotypic changes in cells, suppressing antiapoptotic BCL-2 family...
The perioperative neurocognitive disorder (PND) is a severe complication that affects millions of surgical patients each year. Homocysteine (Hcy) known to increase the risk developing PND in both young and elderly mice. However, whether Hcy alone can induce cognitive deficits middle-aged mice (12-month-old), exercise attenuate Hcy-induced hippocampus-related after surgery through suppressing neuroinflammation, synaptic elimination, level remains unknown. present study aimed answer these...
Cones are responsible for daylight, central, high acuity and color vision. Three proteins found in human cones, i.e. long-wavelength (L)-, middle-wavelength (M)-, short-wavelength sensitive (S)-opsins, red, green blue recognition, respectively. Human cone monochromacy (BCM) is characterized by functional loss of both L- M-cone opsins due to mutations the OPN1LW/OPN1MW gene cluster on X chromosome. BCM patients, who rely their vision from only S-cones rods, suffer severely reduced visual...
Perioperative neurocognitive disorder (PND) is a prevalent form of cognitive impairment in elderly patients following anesthesia and surgery. The underlying mechanisms PND are closely related to perineuronal nets (PNNs). PNNs, which complexes extracellular matrix primarily surrounding neurons the hippocampus, play critical role function. Connexin 43 (Cx43) contributes function by modulating components PNNs. This study was designed investigate specific regulatory Cx43 on PNNs its pivotal...
Synthetic thymosin beta 4 (Tβ4) may have a potential use in promoting myocardial cell survival during acute infarction. Four cohorts, with 10 healthy subjects each, were given single intravenous dose of placebo or synthetic Tβ4. Cohorts received ascending doses either 42, 140, 420, 1260 mg. Following safety review, the same regimen daily for 14 days. Safety evaluations, incidence Treatment‐Emergent Adverse Events, and pharmacokinetic parameters evaluated. events infrequent, mild moderate...
Triple-negative breast cancer (TNBC) is a subtype of cancer, and it has aggressive more frequent tissue metastases than other subtypes. Because the proliferation TNBC tumor cells does not depend on estrogen receptor (ER), progesterone (PR), Erb-B2 tyrosine kinase 2 (HER2) lacks accurate drug targets, conventional chemotherapy challenging to be effective, adverse reactions are severe. At present, treatment strategy for generally depends combination surgery, radiotherapy, chemotherapy....