A5067485324- RNA modifications and cancer
- FOXO transcription factor regulation
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Mechanisms of cancer metastasis
- Ethnobotanical and Medicinal Plants Studies
- Natural Antidiabetic Agents Studies
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Essential Oils and Antimicrobial Activity
- Seed and Plant Biochemistry
- Advances in Cucurbitaceae Research
- Agricultural pest management studies
- Advanced biosensing and bioanalysis techniques
- Tannin, Tannase and Anticancer Activities
- Psidium guajava Extracts and Applications
- Prostate Cancer Treatment and Research
- Phytochemistry and biological activity of medicinal plants
- Pharmacology and Nanomedicine Research
- Plant chemical constituents analysis
- Plant biochemistry and biosynthesis
- Diverse Scientific Research Studies
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Estrogen and related hormone effects
University of Kentucky
2021-2025
Markey Cancer Center
2022-2024
Texas A&M Health Science Center
2024
Texas A&M University
2024
Columbia University Irving Medical Center
2024
Kenya Medical Research Institute
2016-2022
Jomo Kenyatta University of Agriculture and Technology
2018
University of Eastern Africa, Baraton
2013
Abstract A key feature common to triple-negative breast cancer is metabolic reprogramming that contributes the malignant phenotype. Dysregulation of phosphoglycerate kinase 1 (PGK1), an essential player in glycolysis, involved several oncogenic pathways. In current study, we aimed determine whether PGK1-mediated glucose metabolism impacts induction ferroptosis cancer. We found expression PGK1 varies TNBC cell lines, with MDA-MB-231, MDA-MB-458 and MDAMB-453 lines showing significantly higher...
Medicinal plants play a vital role in the traditional treatment of various diseases Africa and world at large. In Nandi county rift valley province Kenya Senna didymobotyya is one most valued traditionally, this mainly attributed to famous mursik milk which plant used as preservative. A study was carried out investigate bioactivity leaves. Organism tested were Escherichia coli, Salmonella typhi, Enterobacter aerogenes , Klebsiella sp., Streptococcus pyogenes isolated from clinical specimens,...
Triple-negative breast cancer (TNBC), characterized by a deficiency in estrogen receptor (ER), progesterone (PR), and human epidermal growth factor receptor2 (HER2), is among the most lethal subtypes of (BC). Nevertheless, molecular determinants that contribute to its malignant phenotypes such as tumor heterogeneity therapy resistance, remain elusive. In this study, we sought identify stemness-associated genes involved TNBC progression. Using bioinformatics approaches, found 55 up- 9...
Abstract Globally, approximately 13% of all deaths annually are attributed to cancer. Surgery, radiation and chemotherapy the current treatment techniques for cancer, however these methods expensive, have high failure rates been associated with detrimental side effects. Plant derived products could be good candidates in alleviating challenges being experienced methods. This study aimed at evaluating phytochemistry, antiproliferation potential, probable mechanism action Albizia gummifera ,...
Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the
Abstract Mitochondria continuously undergo morphologically dynamic processes of fusion and fission to maintain their size, shape, amount, function; yet the precise molecular mechanisms by which mitochondrial dynamics is regulated remain be fully elucidated. Here, we report a previous unappreciated but critical role eukaryotic elongation factor 2 (eEF2) in regulating fission. eEF2, G‐protein superfamily member encoded EEF2 gene humans, has long been appreciated as promoter GTP‐dependent...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
<title>Abstract</title> Triple negative breast cancer (TNBC) is a particularly lethal (BC) subtype driven by stem cells (CSCs) and an immunosuppressive microenvironment. Our study reveals that nucleus accumbens associated protein 1 (NAC1), member of the BTB/POZ gene family, plays crucial role in TNBC maintaining tumor stemness influencing myeloid-derived suppressor (MDSCs). High NAC1 expression correlates with worse prognosis. knockdown reduced CSC markers cell proliferation, migration,...
Triple-negative breast cancer (TNBC), characterized by deficiency in estrogen receptor (ER), progesterone (PR), and human epidermal growth factor receptor2 (HER2), is among the most lethal subtypes of (BC). Nevertheless, molecular determinants that contribute to its malignant phenotype such as tumor heterogeneity therapy resistance remain elusive. In this study, we sought identify stemness-associated genes involved TNBC progression. Using bioinformatics approach, found 55-up 9-down regulated...
Abstract One of the important features triple-negative breast cancer (TNBC) is enrichment stem-like cells that contribute substantially to malignant phenotype. Nucleus accumbens associated protein 1 (NAC1), a unique member BTB-POZ family, implicated in tumor development and progression various types cancer. The objective this study was test hypothesis NAC1 plays critical role maintaining stemness TNBC. We found TNBC cell lines, MDA-MB-231 HCC-1806, had high expressions compared normal....
Mitochondria continuously undergo morphologically dynamic processes of fusion and fission to maintain their size, shape, amount, function; yet the precise molecular mechanisms by which mitochondrial dynamics is regulated remain be fully elucidated. Here, we report a previous unappreciated but critical role eukaryotic elongation factor 2 (eEF2) in regulating fission. eEF2, G-protein superfamily member encoded EEF2 gene human, has long been appreciated as promoter GTP-dependent translocation...
Globally, approximately 13% of all deaths annually are attributed to cancer. Surgery, radiation and chemotherapy the current treatment techniques for cancer; however, these methods expensive, have high failure rates been associated with detrimental side effects. Plant derived products could be good candidates in alleviating challenges being experienced methods. This study aimed at evaluating phytochemistry, antiproliferation potential, probable mechanism action Albizia gummifera, Rhamnus...
Abstract Mitochondria continuously undergo morphologically dynamic processes of fusion and fission to maintain their size, shape, amount, function; yet the precise molecular mechanisms by which mitochondrial dynamics is regulated remain be fully elucidated. Here, we report a previous unappreciated but critical role eukaryotic elongation factor 2 (eEF2) in regulating fission. eEF2, G-protein superfamily member encoded EEF2 gene human, has long been appreciated as promoter GTP-dependent...