Meghan E. McGrath
A5023627225- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Psychosomatic Disorders and Their Treatments
- Stress Responses and Cortisol
- Cardiac Arrest and Resuscitation
- Child Abuse and Trauma
- Emergency and Acute Care Studies
- Trauma and Emergency Care Studies
- Migration, Health and Trauma
- Sepsis Diagnosis and Treatment
- Climate Change and Health Impacts
- Resilience and Mental Health
- Pharmacological Effects and Toxicity Studies
- Mental Health Research Topics
- Traumatic Brain Injury and Neurovascular Disturbances
- Adenosine and Purinergic Signaling
- Memory and Neural Mechanisms
- Sleep and Work-Related Fatigue
- Sleep and Wakefulness Research
- Healthcare Policy and Management
- Disaster Response and Management
- Heart Rate Variability and Autonomic Control
- Functional Brain Connectivity Studies
- Intimate Partner and Family Violence
- Interpreting and Communication in Healthcare
Boston University
2008-2024
Boston Medical Center
2008-2023
McLean Hospital
2021-2022
Emory University
2021-2022
Temple University
2022
Provision Healthcare
2022
University of North Carolina at Chapel Hill
2022
University of Nevada, Las Vegas
2022
University of Arizona
2021-2022
Collaborations Pharmaceuticals (United States)
2021-2022
Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating and the of these events unfolding new psychopathology is not well understood. The authors conducted multisite transdiagnostic longitudinal study exposure related mental health outcomes identify neurobiological predictors risk, resilience, different symptom presentations.
Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma inconsistent. Determining whether trauma-related uniquely predictive later outcomes would enable early identification at-risk populations. The authors conducted largest prospective longitudinal biomarker study persistent to date determine its capacity for adverse following acute trauma. Methods: All...
ABSTRACT Objective: To determine: 1) provider behavior in screening for domestic violence (DV) and sexual assault (SA); 2) training DV SA; 3) knowledge of available protocols 4) perception barriers to intervention. Methods: Anonymous, structured surveys were distributed physicians, nurses, social workers at an adult ED trauma center, affiliated pediatric ED, a women's urgent care center between July September 1995. Results: Of 207 staff members (59%) responding, 54% 68% indicated that they...
Equilibrative nucleoside transporters (ENTs) are present at the blood-testis barrier (BTB), where they can facilitate antiviral drug disposition to eliminate a sanctuary site for viruses detectable in semen. The purpose of this study was investigate ENT-drug interactions with three analogs, remdesivir, molnupiravir, and molnupiravir's active metabolite, <i>β</i>-d-N<sup>4</sup>-hydroxycytidine (EIDD-1931), four non-nucleoside molecules repurposed as antivirals coronavirus disease 2019...
<h3>Importance</h3> A substantial proportion of the 40 million people in US who present to emergency departments (EDs) each year after traumatic events develop posttraumatic stress disorder (PTSD) or major depressive episode (MDE). Accurately identifying patients at high risk ED would facilitate targeting preventive interventions. <h3>Objectives</h3> To and validate a prediction tool based on reports motor vehicle collision predict PTSD MDE 3 months later. <h3>Design, Setting,...
Post-Traumatic Stress Disorder (PTSD) is a psychiatric condition resulting from threatening or horrifying events. We hypothesized that circadian rhythm changes, measured by wrist-worn research watch are predictive of post-trauma outcomes. 1618 patients were enrolled after admission to emergency departments (ED). Three standardized questionnaires administered at week eight measure outcomes related PTSD, sleep disturbance, and pain interference with daily life. Pulse activity movement data...
Many patients in Emergency Departments (EDs) after motor vehicle collisions (MVCs) develop post-traumatic stress disorder (PTSD) or major depressive episode (MDE). This report from the AURORA study focuses on associations of pre-MVC sleep problems with these outcomes 8 weeks MVC mediated through peritraumatic distress and dissociation 2-week outcomes. A total 666 completed self-report assessments ED at 2 MVC. Peritraumatic distress, dissociation, characteristics (insomnia, nightmares,...
Objective. To determine the prevalence of domestic violence against mothers in a pediatric emergency department and relationship their children to abusers. Design. Cross-sectional survey convenience sample seeking treatment for children. Setting. An urban department. Participants. A total 157 with &lt;3 years age. Women were excluded if older or partners present. Results. 52% women reported histories adult physical abuse, 21% sexual 28% childhood abuse. 10% abusive relationships past...
Abstract Background Racial and ethnic groups in the USA differ prevalence of posttraumatic stress disorder (PTSD). Recent research however has not observed consistent racial/ethnic differences early aftermath trauma, suggesting that such chronic PTSD rates may be related to recovery over time. Methods As part multisite, longitudinal AURORA study, we investigated outcomes within 3 months after trauma. Participants ( n = 930) were recruited from emergency departments across provided periodic...
Hippo campal impairments are reliably associated with post-traumatic stress disorder (PTSD); however, little research has characterized how increased threat sensitivity may interact arousal responses to alter hippocampal reactivity, and further these interactions relate the sequelae of trauma-related symptoms. In a sample individuals recently exposed trauma (<i>N</i> = 116, 76 female), we found that PTSD symptoms at 2 weeks were decreased as assessed fMRI. Further, relationship between...
Abstract The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled the emergency department (ED) completed rotating battery brief smartphone-based surveys over...
Cross-sectional studies have found that individuals with posttraumatic stress disorder (PTSD) exhibit deficits in autonomic functioning. While PTSD rates are twice as high women compared to men, sex differences functioning relatively unknown among trauma-exposed populations. The current study used a prospective design examine
<h3>Objective</h3> To assess emergency department (ED) clinicians' attitudes and behaviors regarding identification, assessment, intervention for youth at risk violence in the ED. <h3>Design</h3> Anonymous, cross-sectional written questionnaire. <h3>Setting</h3> The EDs of 3 urban hospitals. <h3>Subjects</h3> Emergency medicine residents faculty, pediatric residents, fellows ED nurses. <h3>Results</h3> A total 184 (88%) 208 clinicians completed Only 15% correctly recognized lack existing...
Abstract Background This is the first report on association between trauma exposure and depression from A dvancing U nderstanding of R ec O very afte traum (AURORA) multisite longitudinal study adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in aftermath a traumatic life experience. Methods We focus presenting at EDs after motor vehicle collision (MVC), which characterizes most AURORA participants, examine associations...
ACADEMIC EMERGENCY MEDICINE 2012; 19:259–264 © 2012 by the Society for Academic Emergency Medicine Abstract Objectives: Sepsis is characterized an initial systemic proinflammatory response leading to endothelial damage and increased capillary permeability. The authors conducted a pilot study determine if microalbuminuria, measured urine albumin:creatinine ratio (ACR), was associated with outcome in emergency department (ED) sepsis patients. Methods: This observational cohort of convenience...
Literature demonstrates the detrimental impact of discrimination and microaggressions at personal institutional levels in health care workplace. Residents our program requested curricula to help with addressing manifestations bias. In response, we designed implemented an adaptable reproducible 4-hour virtual simulation session aimed helping residents identify constructively respond microaggressions.