A5102875469- Inflammatory Bowel Disease
- Pharmacological Effects of Natural Compounds
- Galectins and Cancer Biology
- Lymphoma Diagnosis and Treatment
- Microscopic Colitis
- earthquake and tectonic studies
- Chronic Lymphocytic Leukemia Research
- Pediatric Urology and Nephrology Studies
- Seismology and Earthquake Studies
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- Urinary Tract Infections Management
- Urinary and Genital Oncology Studies
- Gastrointestinal Bleeding Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Seismic Waves and Analysis
- Bladder and Urothelial Cancer Treatments
- Helicobacter pylori-related gastroenterology studies
- Kidney Stones and Urolithiasis Treatments
- Gastric Cancer Management and Outcomes
- Renal Diseases and Glomerulopathies
- Diverticular Disease and Complications
- Gastrointestinal disorders and treatments
- Intracranial Aneurysms: Treatment and Complications
- Urological Disorders and Treatments
Kitasato University
2016-2025
Kitasato Institute Hospital
2016-2025
Japan Agency for Marine-Earth Science and Technology
2021
Toyohashi Municipal Hospital
2020
Tokyo Denki University
2019
Nagoya City University
2017
Niigata University
2013-2016
Seirei Hamamatsu General Hospital
2011-2013
University of Groningen
2013
Children's Medical Center
2010-2011
Leucine-rich α-2-glycoprotein (LRG) is a new serum biomarker reflecting the disease activity of ulcerative colitis (UC), but its change during acute phase has not been enough investigated.
✓ The case is presented of a 36-year-old woman with plasma-cell granuloma arising in the fourth ventricle. mass appeared on computerized tomography as well circumscribed area slightly high density that was markedly enhanced contrast medium. Microscopic examination showed mixed-cell population predominance plasma cells, and tumor characterized immunohistochemically by polyclonal proliferation.
Eradication of Helicobacter pylori (H. pylori) is an effective strategy for preventing various gastrointestinal diseases such as gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. However, the eradication success rate decreasing because a recent increase in drug-resistant strains H. pylori. Here, we evaluated therapy with vonoprazan (VPZ), new potassium-competitive acid blocker, against In total, 793 patients who received were investigated retrospectively. All underwent...
ABSTRACT Background Intestinal ultrasound (IUS) is a non‐invasive tool for evaluating transmural inflammation in Crohn's disease (CD). However, its utility constrained by operator dependency and limited accessibility. Aims To explore the feasibility of serum biomarkers—specifically leucine‐rich alpha‐2 glycoprotein (LRG)—as an alternative to IUS assessing inflammation. Methods This retrospective, single‐centre study included patients with CD who underwent measurements LRG C‐reactive protein...
Abstract Background Patients with ulcerative colitis (UC) may have bowel urgency (BU), which has been recognised as important due to its links anxiety, depression, and reduced social quality of life. This study examines intestinal ultrasound (IUS) findings associated BU, comparing them endoscopic biomarkers. Methods prospective, single-centre included UC patients undergoing colonoscopy from January September 2023. Transabdominal transperineal IUS was performed, assessing wall thickness...
JAMSTEC have been monitoring changes in underground fluid pressure, or "pore pressure," from boreholes near the site of 1944 Tonankai earthquake southwestern Japan. These are linked to Slow Slip Events (SSEs), which occur on boundary between Eurasian plate and subducting Philippine Sea beneath Nankai Trough. By connecting their borehole observatory (LTBMS) a seafloor network (DONET), they now collect real-time pore pressure data, allowing them update SSE catalog.This updated catalog revealed...
Introduction: A large proportion of small bowel lesions in Crohn’s disease (CD) may exist beyond the reach ileocolonoscopy and there is no gold standard imaging modality to screen them, suggesting need for optimal biomarkers. We aimed compare usefulness C-reactive protein (CRP), faecal calprotectin (FC), leucine-rich alpha-2 glycoprotein (LRG) determining CD. Methods: This was a cross-sectional observational study. CRP, FC, LRG were prospectively measured patients with quiescent CD who...
✓ The authors report the results of inhibition thromboxane A 2 synthetase in 49 consecutive patients with subarachnoid hemorrhage (SAH). These unselected Grade I to IV all had a ruptured aneurysm anterior circle Willis, and were operated on within 72 hours after SAH. Twenty-seven treated postoperatively by an intravenous infusion sodium(E)-3-[4-(3-pyridylmethyl)-phenyl]-2-propenoate (OKY-1581), selective inhibitor synthetase, at 5 µ g/kg/min for 10 14 days, remaining 22 did not receive this...
Background Fecal calprotectin (FC) is well accepted as a non-invasive biomarker which objectively reflects colonic inflammation in ulcerative colitis (UC). However, its value marker of response during the early phase remission induction treatment has not been studied. The aim this study to evaluate significance FC for predicting short-term outcomes patients with UC. Methods A prospective observational was conducted among 31 active monitored two-item patient-reported outcome (PRO2), partial...
The usefulness of second-generation colon capsule endoscopy (CCE-2) for ulcerative colitis (UC) has not been fully demonstrated. This study aimed to develop an endoscopic severity score UC CCE-2. Patients diagnosed with were enrolled prospectively and underwent colonoscopy CCE-2 on the same day. collected videos adopted development score. These scored by 4 blinded inflammatory bowel disease experts. items validated Ulcerative Colitis Endoscopic Index Severity (UCEIS) used as candidate items,...
We tested 2 prototypes of an operating fiberoptic nephroureteroscope, measuring 3.5 and 4.5 mm. in diameter, that have adequate working channel for auxiliary instruments irrigation. Difficulty passing the fiberscope through ureteral orifice was overcome by dilation with balloon polytetrafluoroethylene (Teflon) dilators. Our initial trial stone retrieval under fiberscopic control performed on 21 patients upper renal calculi. A removed successfully 15 (71 per cent). After electrohydraulic...
Although urinary biochemical markers can be assessed by their ratio to creatinine (U-Cr) concentration, reference values in adults may not applicable children because the amount of Cr excreted varies body size. We therefore measured relationship between age and ratios β-2-microglobulin (U-β2MG), N-acetyl-β-d-glucosaminidase (U-NAG), calcium (U-Ca) protein (U-Pr) concentration those U-Cr children.Fifty-seven patients aged >1 year with benign familial hematuria (median age, 6.3 years) were...
We treated 34 patients with staghorn calculi by fiberoptic transurethral nephrolithotripsy a flexible nephroureteroscope and an electrohydraulic lithotriptor. Of the 30 (88.2%) were successfully. There 17 each complete partial calculi. was no difference in success ratio rate of residual fragments between 2 groups. However, post-procedural fever, sepsis extrapelvic extravasation observed more frequently than Countermeasures to avoid complications must be developed future. we believe that is...
This retrospective study was performed to assess the 3 year outcome of a unified protocol for childhood idiopathic nephrotic syndrome.Cyclosporine A (CsA) or CsA plus mycophenolate mofetil (MMF) were used in patients without remission on high-dose steroid therapy. maintained at an area under whole blood concentration-time curve up 4 h after dose (AUC0-4 ) 1500 and 2000 ng·h/mL steroid-dependent syndrome (SDNS) steroid-resistant (SRNS), respectively. Ninety-one children enrolled (SDNS, n =...
Abstract Background and Aim The usefulness of second‐generation colon capsule endoscopy (CCE2) in ulcerative colitis (UC), especially clinically inactive patients, has been reported. Capsule Scoring Ulcerative Colitis (CSUC) was developed as a severity index for UC. We aimed to determine whether CSUC is useful predicting relapse during clinical remission. Methods Forty‐one UC patients remission who underwent CCE2 were prospectively registered from April 2016 August 2019. Patients' score...
Abstract Background Developmental programming of chronic kidney disease (CKD) in young adults is linked to preterm birth and intrauterine growth restriction (IUGR). Which confers a higher risk progression damage children with very low weight (VLBW; born weighing < 1500 g): prematurity or IUGR? Methods This national historical cohort study VLBW cared for perinatal medical centers Japan. Predictive factors included three latent variables (prematurity, IUGR, stress during neonatal period)...
Abstract Background The aim of this study was to examine the sensitivity and specificity pyuria‐based diagnosis urinary tract infection ( UTI ) in urine collected by transurethral catheterization, reliability pyuria a perineal bag. gold standard for is significant colony counts single organism obtained sterile manner. Methods We enrolled 301 patients who underwent medical examination at present hospital possible between January 2005 December 2009. 438 samples catheterization. investigated...
Abstract Purpose : The score to predict the risk of post‐extracorporeal shock wave lithotripsy (ESWL) pyelonephritis was evaluated. based on multivariate analysis factors available pre‐operatively. Stone size, pyuria, bacteriuria, previous and other adjunctive procedures had been selected scored. Methods Three‐hundred forty‐eight adult patients without active urinary infection undergoing ESWL therapy were studied. One three regimens by either doctor or patient: (i) no antimicrobial...