A5103428768- Bone Tissue Engineering Materials
- Polymer Surface Interaction Studies
- Calcium Carbonate Crystallization and Inhibition
- Orthopaedic implants and arthroplasty
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Electron and X-Ray Spectroscopy Techniques
- Electrospun Nanofibers in Biomedical Applications
- Molecular Junctions and Nanostructures
- Surface and Thin Film Phenomena
- X-ray Diffraction in Crystallography
- Nanofabrication and Lithography Techniques
- Bone health and osteoporosis research
- Titanium Alloys Microstructure and Properties
- Bone Metabolism and Diseases
- Advanced Machining and Optimization Techniques
- Advanced Photocatalysis Techniques
- Additive Manufacturing and 3D Printing Technologies
- Bone and Dental Protein Studies
- Collagen: Extraction and Characterization
- Quantum Dots Synthesis And Properties
- Bacterial biofilms and quorum sensing
- Extraction and Separation Processes
- Recycling and Waste Management Techniques
University of Hong Kong
2009-2024
Sun Yat-sen University
2021-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2021-2024
Hong Kong University of Science and Technology
2008-2019
Jinan University
2018
Hohai University
2015
Kowloon Hospital
2014
Jiangsu University
2013
Peking University
2008
Bioengineering Center
2008
Surface-adherent polydopamine (PDA) films as multifunctional coatings can be easily deposited onto a wide range of materials through dopamine self-polymerization. However, lack in-depth understanding PDA aggregation and deposition processes definite structure elucidation make it challenging to tailor the surface characteristic functionality films. Herein, we demonstrate that characteristics readily tuned by controlling competitive interplay between in solution on substrate. Moreover,...
Abstract Osteoinductivity of hydroxyapatite (HA) was investigated using uncommitted pluripotent mouse stem cells, C3H10T1/2 in an vitro differentiation assay. For comparative analysis, the cells were cultured on substrates made osteoinductive HA, with biocompatible titanium and plastics as negative control. HA exhibited ability to induce expression osteo‐specific genes C3H10T1/2, including alkaline phosphatase (ALP), type I collagen, osteocalcin; compared its insignificant up‐regulation same...
A one-step method to deposit a functional amine-rich coating in dopamine and hexamethylendiamine mixed solution through simple dip-coating of objects.
Implant-associated infections are generally difficult to cure owing the bacterial antibiotic resistance which is attributed widespread usage of antibiotics. Given global threat and increasing influence resistance, there an urgent demand explore novel antibacterial strategies other than using Recently, a certain surface topography provide more persistent solution attracts attention. However, clinical application biomimetic nano-pillar array not satisfactory, mainly because its ability against...
Exosomes, the nano-vesicles released from living cells, were important mediator for cell-to-cell communication.In order to clarify whether exosomes derived obesity adipose tissue mediate insulin resistance of hepatocytes, we extract different mice models.Exosomes ob/ob (Ob-exosomes), B6 fed with a high-fat diet (HFD-exosomes) and normal (WT-exosomes) displayed similar size molecular makers, but their effect on sensitivity hepatocytes obviously or opposite.Abundant exosomal miRNAs in Ob-,...
Hydroxyapatite (HA) coatings on titanium (Ti) substrates have attracted much attention owing to the combination of good mechanical properties Ti and superior biocompatibility HA. Incorporating silver (Ag) into HA is an effective method impart with antibacterial properties. However, uniform distribution Ag still a challenge particles in are easy agglomerate, which turn affects applications coatings. In this study, we employed pulsed electrochemical deposition co-deposit simultaneously,...
A mussel-inspired surface functionalization of the polydopamine (PDA) coating has been demonstrated to be a promising strategy ensure biocompatibility various biomaterials. To explore multifunctionality PDA for vascular stents and elucidate mechanisms by which modulates cell behavior, this study examined protein adsorption, responses endothelial cells (ECs) smooth muscle (SMCs), platelet adhesion PDA-coated surfaces synthesized at varied initial dopamine concentrations. Our results indicate...
For a basic understanding and potential biomedical applications of surface topographical effects on bacterial responses, this study focuses not only the retention but also growth, proliferation, viability that are significant post-retentive behaviors playing critical roles in infections medical implants. Specifically, periodic micropillar arrays (SiPA ) with nine different feature sizes were fabricated silicon substrates photolithography dry etching methods. The SiPA was cultured...
It is great challenge to generate multifunctionality of vascular grafts and stents enable cell selectivity improve hemocompatibility. Micro/nanopatterning implant surfaces for such a direction be explored. We developed novel patterned platform featuring two typical geometries (groove pillar) six pattern sizes (0.5–50 μm) in single substrate evaluate the response cells platelets. Our results indicate that targeted can indeed instructed by rationally designed surface topography. The pillars...
Here, we report the sintering of aggregated submicron cubic boron nitride (sm-cBN) at a pressure 8 GPa. The sintered cBN compacts exhibit hardness values comparable to that single crystal diamond, fracture toughness about 5-fold crystal, in combination with high oxidization temperature. Thus, another way has been demonstrated improve mechanical properties besides reducing grain size nano scale. In contrast other ultrahard similar hardness, sm-cBN aggregates are better placed for potential...
Abstract In the present study, surface functional groups of titanium surfaces gone through different treatments, including acid etched treatment (AE), nitric (NT), heat (HT), and alkali (AT), their behaviors in vitro vivo was thoroughly studied by spectroscopic analysis. results revealed that rank bioactivity various AE < NT HT AT. XPS analysis indicated AT greatly increased OH group concentration on whereas reduced concentration. Thus, difference could not be a good explanation...
Carbonated apatite, the basic mineral component in human hard tissues and an important bioceramic material, has been extensively studied. However, its atomic arrangements apatite crystal structure experimental characterization are still not lack of debating. We analyzed infrared (IR) vibrational spectroscopy for carbonated determinations, by comparatively studying IR spectra hydroxyapatite surface carbonate absorption, biological apatites (human enamel, cortical bone, two animal bones)...
Abstract The effects of implant surface topography and chemistry on osteoblast behavior have been a research focus because their potential importance in orthopedic dental applications. This work focused the topographic hydroxyapatite (HA) titanium (Ti) that had identical micropatterns to determine whether there was synergistic interaction between topography. Surface microgrooves with six different groove widths (4, 8, 16, 24, 30, 38 μm) three depths (2, 4, 10 were made single crystalline...
Abstract Surface topography is one of the most important surface properties biomaterials and microfabrication techniques provide new routes to produce precisely controlled topographies for investigating topographic effects on cell behavior. In this study, hydroxyapatite (HA) microgrooved surfaces were used study osteoblast myoblast response micro‐features. The microgrooves first produced silicon wafers by photolithography, then coated with HA using sputtering technique. Orientation angle...
Biomimetic carbonated apatite (CAp) nanoparticles with tunable size, morphology and ultrastructure were synthesized via a facile hydrothermal route. By combining the results of FTIR, XRD, ICP, TGA, TEM HRTEM, complete chemical, morphological structural characterization was performed. Based on systematic examination effect fundamental factors including pH, carbonate concentration, temperature, reaction time that control synthesis CAp nanocrystals, nucleation growth mechanisms proposed. The...
Abstract This study systematically investigated the effects of microtopographic patterns titanium oxide on platelet adhesion and activation in order to reveal mechanisms interactions between surface topography. Periodic arrays groove pillar with dimensions ranging from submicron several micrometers were fabricated by photolithography deep reactive‐ion etching silicon substrates, followed sputter deposition (TiO 2 ). Platelet TiO patterned surfaces evaluated lactate dehydrogenase (LDH)...