A5059187219- Advanced Breast Cancer Therapies
- Cellular Mechanics and Interactions
- Cancer-related molecular mechanisms research
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- RNA regulation and disease
- Advanced Fluorescence Microscopy Techniques
- Polyamine Metabolism and Applications
- RNA Research and Splicing
- Cell Image Analysis Techniques
- Immune Cell Function and Interaction
National University of Singapore
2021-2024
Cornell University
2024
Weill Cornell Medicine
2024
National University Cancer Institute, Singapore
2021
Solute carrier (SLC), a diverse family of membrane proteins, are instrumental in orchestrating the intake and efflux nutrients including amino acids, vitamins, ions, nutrients, etc, across cell membranes. This dynamic process is critical for sustaining metabolic demands cancer cells, promoting their survival, proliferation, adaptation to tumor microenvironment. Amino acids fundamental building blocks playing essential roles not only protein synthesis but also nutrient sensing, signaling...
Immune cells have intensely physical lifestyles characterized by structural plasticity and force exertion. To investigate whether specific immune functions require stereotyped mechanical outputs, we used super-resolution traction microscopy to compare the synapses formed cytotoxic T with contacts other cell subsets macrophages. were globally compressive, which was fundamentally different from pulling pinching associated macrophage phagocytosis. Spectral decomposition of exertion patterns...
Actomyosin-mediated cellular contractility is highly conserved for mechanotransduction and signalling. While this phenomenon has been observed in adherent cell models, whether/how contractile forces regulate the function of suspension cells like natural killer (NK) during cancer surveillance, unknown. Here, we demonstrated coculture settings that evolutionarily NK transcription factor, Eomes, undergoes nuclear shuttling lung surveillance. Biophysical biochemical analyses revealed mechanistic...