A5085718883- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- T-cell and Retrovirus Studies
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Folate and B Vitamins Research
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Graphene and Nanomaterials Applications
- Microfluidic and Bio-sensing Technologies
- Curcumin's Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Supercapacitor Materials and Fabrication
- Nanopore and Nanochannel Transport Studies
- Genetic Associations and Epidemiology
- Luminescence Properties of Advanced Materials
- Cancer Genomics and Diagnostics
- T-cell and B-cell Immunology
- Neutropenia and Cancer Infections
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Layered Double Hydroxides Synthesis and Applications
- Electrohydrodynamics and Fluid Dynamics
Shandong Provincial Hospital
2022-2025
Shandong University
2014-2025
Ministry of Education of the People's Republic of China
2016
Hangzhou Medical College
2016
Natural killer (NK) cell belongs to innate lymphoid family that contributes host immunosurveillance and defense without pre-immunization. Emerging studies have sought understand the underlying mechanism behind NK dysfunction in tumor environments, provide numerous novel therapeutic targets for treatment. Strategies enhance functional activities of exhibited promising efficacy favorable tolerance clinical treatment patients, such as immune checkpoint blockade (ICB), chimeric antigen receptor...
Ultrathin MnO2 hollow nanoballoons (UMHNBs) have a large ratio of interfacial to total atoms, corresponding expected improved performance. However, their synthesis is challenge due difficulty in controlling the concentration unit cells. Herein, we describe strategy synthesize dry intact UMHNBs through one-step by inflating (reduced from KMnO4) with CO2 (oxidized single-layer graphene oxide nanosheets) followed instant freeze-drying. are 30–500 nm diameter shell thickness 3.7 nm, packing...
Abstract T‐cell lymphoma (TCL) is a group of non‐Hodgkin's with high heterogeneity and unfavorable prognosis. Current standard treatments have demonstrated limited efficacy in improving the outcomes for TCL patients. Therefore, identification novel drug targets urgently needed to improve prognosis Through multi‐omics analysis, aberrant expression threonine tyrosine kinase (TTK) identified. High TTK closely associated poor Targeting through gene knockdown exerts anti‐tumor effects vitro vivo,...
Abstract Background Peripheral T cell lymphoma (PTCL) is characterized by high heterogeneity, strong aggressiveness, and extremely poor prognosis. Ferroptosis, a novel form of programmed death, has been involved in tumor development targeting ferroptosis holds great potential for therapy. Methods Lentiviral transfection was performed to regulate gene expression, followed Tandem mass tag (TMT)-mass spectrometry RNA-sequencing. Tumor xenograft models were established vivo experiments. Results...
Topic: 20. Lymphoma Biology & Translational Research Background: Ferroptosis, characterized by reactive oxygen species (ROS) accumulation and lipid peroxidation, is a kind of specialized cell death dependent on iron metabolism. Accumulating evidence indicates that ferroptosis involved in the development several tumors, targeting holds great potential for tumor therapy. Aims: Herein, we aim to investigate regulatory networks its molecular mechanisms peripheral T lymphoma (PTCL). Methods:...
One-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a (eIF3a) is a key player in the initial stage translation, which has been widely reported to be correlated with tumorigenesis and therapeutic response. This study aimed explore biological role eIF3a, evaluate its prognostic potential DLBCL.
Abstract Hepatocellular carcinoma (HCC) is a major cause of cancer deaths globally. Unlike traditional molecularly targeted drugs, magnetically controlled drug delivery to micro/nanorobots enhances precision in targeting tumors, improving efficiency and minimizing side effects. This study develops dual‐responsive, system using PEGylated paramagnetic nanoparticles conjugated with decoy receptor 3 (DCR3) antibodies. The clusters demonstrate capabilities for long‐range, driven control molecular...
Prostaglandin D2 (PGD2), an arachidonic acid metabolite, has been implicated in allergic responses, parasitic infection and tumor development. The biological functions molecular mechanisms of PGD2 diffuse large B-cell lymphoma (DLBCL) are still undefined. In this study, we firstly found the high concentration serum low expression receptor CRTH2 DLBCL, which were associated with clinical features prognosis DLBCL patients. Interestingly, different displayed divergent effects on progression....
A strategy of employing graphene oxide (GO) nanosheets to prepare large-area GO films is proposed in this work. The are prepared by injecting suspension a mixture water and ethanol (H2O + EtOH) at the liquid/liquid (hexane/water, C6H14/H2O) interface forming interface. After evaporation C6H14, air/(H2O transferred onto solid substrates horizontal lifting deposition, large area (2.5 cm × 2.5 cm) homogeneous with thickness 5.4 nm roughness 3.6 obtained. formation scheme C6H14/(H2O discussed...
Chronic kidney disease (CKD) is an increasing contributor to the socio-economic burdendisease burden in China and globally. Previous findings indicated that experience of exposure childhood famine associated with various chronic illnesses diseases such as diabetes, hypertension high blood pressure, proteinuriaurinary protein levels. However, no clear conclusions were drawn about long term consequences human early life on adulthood function. In this study, we aimed explore whether Chinese...
Objective To explore the application effects of Skinner process teaching and its reinforcement theory in health education cancer patients with PICC placements so as to improve quality nursing. Methods We recruited for first time oncology department a class Ⅲ grade I hospital Cangzhou from January 2015 June 2015. They were randomly divided into control group (84 cases, routine education) experimental (81 applying theory). The intervention was carried out 4 chemotherapy cycles. We...