A5003966256- Wound Healing and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Burn Injury Management and Outcomes
- Mesenchymal stem cell research
- Impact of Technology on Adolescents
- Extracellular vesicles in disease
- Traumatic Brain Injury and Neurovascular Disturbances
- Sirtuins and Resveratrol in Medicine
- Cell Adhesion Molecules Research
- Neuroscience and Neuropharmacology Research
- Eating Disorders and Behaviors
- Cancer-related molecular mechanisms research
- Genetic Associations and Epidemiology
- Adolescent and Pediatric Healthcare
- Vanadium and Halogenation Chemistry
- Neurological Complications and Syndromes
- Dermatology and Skin Diseases
- Diabetic Foot Ulcer Assessment and Management
- Nonmelanoma Skin Cancer Studies
- Dental materials and restorations
- Bone Metabolism and Diseases
- Bone fractures and treatments
- Hydrogen's biological and therapeutic effects
- Digital Mental Health Interventions
- Psoriasis: Treatment and Pathogenesis
Air Force Medical University
2013-2024
Xijing Hospital
2013-2024
University of Washington
2023-2024
Qingdao University
2021
People's Hospital of Cangzhou
2021
Creative Commons
2018
National Natural Science Foundation of China
2018
Thomas Jefferson University
2015
Tang Du Hospital
2015
National Institute of Neurological Disorders and Stroke
2015
Abstract Emotional distress (ED), commonly characterized by symptoms of depression and/or anxiety, is prevalent in patients with cancer. Preclinical studies suggest that ED can impair antitumor immune responses, but few clinical have explored its relationship response to checkpoint inhibitors (ICIs). Here we report results from cohort 1 the prospective observational STRESS-LUNG study, which investigated association between and efficacy first-line treatment ICIs advanced non-small-cell lung...
Objective Studies have shown that the therapeutic effects of mesenchymal stem cells (MSCs) are mediated in a paracrine manner, mainly through extracellular vesicles such as exosomes. Here, we designed study to investigate whether exosomes derived from adipose-derived (ADMSC-Exos) had protective rat model radiation-induced brain injury and microglia. Methods Male adult Sprague-Dawley (SD) rats were randomly divided into three groups: control group, radiation group (30 Gy), + Gy 100 ug...
Psychiatric disorders are emerging as a serious public health hazard, influencing an increasing number of individuals worldwide. However, the effect modifiable lifestyle factors on psychiatric remains unclear. Genome-wide association studies (GWAS) summary statistics were obtained mainly from Genomics Consortium and UK Biobank, with sample sizes varying between 10,000 1,200,000. The two-sample Mendelian randomization (MR) method was applied to investigate causal associations 45 13 disorders,...
In current military conflicts and civilian terrorism, blast-induced traumatic brain injury (bTBI) is the primary cause of neurotrauma. However, effects mechanisms bTBI are poorly understood. Although previous researchers have made significant contributions to establishing animal models for simulation bTBI, precision controllability in must be improved. Therefore, we established a novel rat model simulate blast-wave brain. To different extents injury, animals were divided into moderate severe...
Background Vocational education is an important part of high school in China. However, there little research on students' mental health. This study aimed to investigate the prevalence suicidal behavior (SB) among this population and mediating role insomnia, depression, anxiety, stress relationship between Internet addiction (IA) SB using a structural equation model. Methods A cross-sectional questionnaire survey was conducted several vocational students Hunan Province, 7,968 valid...
The treatment of donor sites after split-thickness skin grafting (STSG) is a routine operation step, and complications at the site due to improper care are unwelcome. This study evaluates whether use platelet-rich plasma (PRP) applied STSG area promotes wound healing improves scar development. Clinical data 30 patients who underwent operations between January 2016 2017 for various reasons were retrospectively analyzed. These received two treatments summed up in groups: PRP group, which was...
Protein kinase Cζ (PKCζ) is a member of the atypical protein C family. Its roles in macrophages or skin-resident keratinocytes have not been fully evaluated. In this study, we provide evidence that PKCζ mediates lipopolysaccharide (LPS)-induced tumor necrosis factor α (TNFα) gene expression mouse macrophage cell line, RAW264.7. TNFα has proven to be one main culprits chronic wounds and impaired acute wounds, which are characterized by excessive inflammation, enhanced proteolysis reduced...
Mental health problems among adolescents are a common concern globally. However, its relationship with childhood trauma is not clearly understood from the existing studies. Therefore, this study aims to explore relationships trauma, mental health, self-control, and internet addiction in Chinese vocational high school students.
Sepsis is a complex inflammatory disorder in which high mortality associated with an excessive response. Inhibitor of growth 4 (ING4), cofactor histone acetyltransferase and deacetylase complexes, could negatively regulate this inflammation. However, the exact molecular signaling pathway regulated by ING4 remains uncertain. As pivotal deacetylase, Sirtuin1 (SIRT1), widely accepted to be anti-inflammatory molecule, has not been found linked ING4. This study investigated how involved...
Glutamate-induced excitotoxicity is involved in many neurological diseases. Preso, a novel postsynaptic scaffold protein, mediates excitatory synaptic transmission and various functions. In this study, we investigated the role of Preso regulation glutamate-induced rat cortical neurons. Knockdown with small interfering RNA improved neuronal viability attenuated elevation lactate dehydrogenase (LDH) release after glutamate treatment. Downregulation also inhibited an increase BAX/Bcl-2 ratio...
Genistein (Gen) exhibits strong anti-oxidative/antinitrative activity and cardioprotective effects in several models; however, its role burn-induced myocardial injury is unknown. This study investigated the protective effect of Gen on aimed to elucidate mechanism protection. Mice were injected with Gen, intraperitoneally, at different dose immediately after burn injury. The expression levels Notch-1 intracellular domain (NICD1) hairy enhancer split (Hes-1) determined by immunoblotting....
Cholangiocarcinoma (CCA) is a malignant tumor with high incidence. The therapeutic effect of conventional chemotherapy and radiotherapy not obvious. Photodynamic therapy (PDT) an ideal modality to fight cancer, the nature photosensitizer limits its application in clinical therapy. aim this study was explore novel mode drug delivery for intervention bile duct cancer.Oxaliplatin HCE6 were loaded mesoporous silica nanoparticles (MSNs) synthesize Oxaliplatin/HCE6-MSNs (OH-MSNs); structure...
Infections of burn wounds, especially those caused by Pseudomonas aeruginosa, could trigger sepsis or septic shock, which is the main cause death after injury. Compared with traditional saline-wet-to-dry dressings, negative pressure wound therapy (NPWT) more effective for prevention and treatment infections. However, mechanism NPWT controls infection accelerates healing remains unclear. Accordingly, in this study, molecular mechanisms underlying effects were explored using a murine model P....
Abstract We aimed to introduce a technique by combining free fascia flaps transfer with split-thickness skin graft for the reconstruction of deep burn wounds at ankle. Fifteen patients from 2009 2016 were enrolled in this study. Patients series suffered injury around ankle, which was accompanied exposure tendon and medial or lateral malleolus due severe soft-tissue defects (N = 15). All 15 repaired operations, including nine anterolateral thigh lata (ATFL flaps) six superficial temporal (STF...
The aim of this study was to describe the scheme, surgical procedures, and clinical outcomes for early repair deep wounds posterior talocrural region in extensively burned patients with a method combining superficial temporal fascia free flap thin split-skin grafting. From January 2013 February 2016, 9 tissue defects were treated our department (2 had bilateral region). All 11 repaired using After operation, survival flaps grafted skin observed, appearance functional recovery grafts...
This study aimed to introduce a novel technique for reconstructing electricity-damaged fingers using method combining the free vascularized anterolateral thigh fascia lata flap with skin grafting. From February 2015 March 2017, 11 patients were enrolled in this retrospective case series. All suffered from electrical injury of and had severe soft tissue defects, exposure tendon, vessels, or nerves. finger wounds covered flaps combined Eleven completely survived. Two partial grafting necrosis...