A5114535295- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Esophageal and GI Pathology
- Metabolomics and Mass Spectrometry Studies
- Ferroptosis and cancer prognosis
- Lung Cancer Diagnosis and Treatment
- Sulfur Compounds in Biology
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Plant-based Medicinal Research
- Adipose Tissue and Metabolism
- Pancreatitis Pathology and Treatment
- Folate and B Vitamins Research
Tengzhou Central People's Hospital
2013-2025
Shanghai Jiao Tong University
2025
Nanjing University of Chinese Medicine
2019
Jining Medical University
2013
Abstract Background Membrane lipids play a crucial role in brain function and cell signalling, they serve as key biological substrates inflammatory responses, thrombosis, energy metabolism. Multiple clinical molecular evidences suggest that membrane are probably involved the pathogenesis of ischemic stroke (IS). However, current knowledge about lipid landscape its involvement IS pathophysiology is limited. Methods We performed untargeted lipidomic analysis on erythrocyte membranes from 56...
Aims: The aim of the present study was to investigate role endoplasmic reticulum stress and apoptosis in experimental diabetic nephropathy. effects ACE inhibitor on were also assessed.
Background: Cold exposure (CE) can effectively modulate adipose tissue metabolism and improve metabolic health. Although previous metabolomics studies have primarily focused on analyzing one or two samples from serum, brown (BAT), white (WAT), liver samples, there is a significant lack of simultaneous analysis multiple tissues regarding the changes induced by CE in mice. Therefore, our study aims to investigate profiles major involved. Methods: A total 14 male C57BL/6J mice were randomly...
To evaluate the clinical value of multiband mucosectomy (MBM) for treatment squamous intraepithelial neoplasia esophagus.A total 51 lesions located at esophagus from 43 patients were treated with MBM, among which 11 diagnosed as middle-grade neoplasia, 25 high-grade and 15 early esophageal cancer pathologically. Primary end-points rate complete endoscopic resection mean operation time; second postoperative local recurrence acute plus complications. The histopathological results compared...
The study aimed to investigate the effect of processing on lectin protein in four toxic Chinese medicines tubers Pinellia ternata,P. pedatisecta,Arisema heterophyllum and Typhonium giganteum. Western blot was used semi-quantitatively analyze content kinds their different processed products. Raw products were treated by heating or soaking ginger juice alum solution. effects excipients methods proteins investigated. results showed that raw P. pedatisecta,P. ternata,A. heterophyllum,and T....
Acute pancreatitis (AP) is a complex inflammatory condition with rising incidence globally. Despite various known causes, early diagnosis remains challenging due to limitations in existing biomarkers. Metabolomics offers promising avenue for identifying novel biomarkers and elucidating underlying pathophysiological mechanisms. Previous AP metabolomics studies primarily focused on analyzing serum, urine, pancreatic tissues from patients or animal models. However, systematic that analyze...
Objective To study the expression of endogenous cystathionine-β-synthase (CBS) and hydrogen sulfide in patients with ulcerative colitis (UC), explore their possible role pathogenesis UC. Methods Thirty active period UC (active group), 30 remission (remission group) healthy controls (control were selected, SABC method was used to observe localization CBS rectal mucosal tissues. The optical density value analyzed image analysis systems. relative mRNA mucosa tissue detected by reverse...